The study of socioethical issues in systems biology

Systems biology is the rapidly growing and heavily funded successor science to genomics. Its mission is to integrate extensive bodies of molecular data into a detailed mathematical understanding of all life processes, with an ultimate view to their prediction and control. Despite its high profile and widespread practice, there has so far been almost no bioethical attention paid to systems biology and its potential social consequences. We outline some of systems biology's most important socioethical issues by contrasting the concept of systems as dynamic processes against the common static interpretation of genomes. New issues arise around systems biology's capacities for in silico testing, changing cultural understandings of life, synthetic biology, and commercialization. We advocate an interdisciplinary and interactive approach that integrates social and philosophical analysis and engages closely with the science. Overall, we argue that systems biology socioethics could stimulate new ways of thinking about socioethical studies of life sciences.     

Trait Stability and Continuity in Childhood: Relating Sociability and Hostility to the Five-Factor Model of Personality

We investigated the continuity of personality constructs in the Oregon Youth Substance Use Project, a cohort-sequential study encompassing development from early childhood to adolescence with five annual or biennial assessments. Sociability and Hostility, assessed by teachers' ratings of children's behaviors at each assessment, were related to the traits comprising the Five-Factor model assessed by teachers' ratings at the fifth assessment. Confirmatory factor analysis demonstrated that Sociability and Hostility were reliably measured at each assessment, and these constructs were relatively stable over time (mean rank-order stability coefficients over intervals of 1-5 years were .50 and .43, respectively). Sociability was most strongly associated (positively) with Extraversion, and Hostility was most strongly associated (negatively) with Conscientiousness and Emotional Stability. No differences were found for younger versus older children. Implications for measuring childhood personality traits using teachers' reports of early childhood behavior are discussed.     

Gender Role Stress in Relation to Shame,Guilt, and Externalization

This study explored how gender role stress variables are related to shame‐proneness, guilt‐proneness, and externalization. Undergraduates completed the Test of Self‐Conscious Affect and the Masculine or Feminine Gender Role Stress Scale, respectively. Canonical analyses revealed 3 significant roots for the male sample accounting for 50% of the total variance between gender role stress and self‐conscious emotions, and 1 significant root for the female sample accounting for 31% of the variance. The discussion examines the complex relationship between gender role ideals and the experience of shame, guilt, and the use of externalization as a defense against these painful affects.     

Maltreated Children's Emotional and Behavioral Problems: Do Teachers and Parents See the Same Things?

We examined whether parent/caregivers and teacher/therapists differ in their perceptions of the behavior problems of young maltreated children. The sample consisted of 33 maltreated preschoolers (58% neglected, 24% sexually abused, 18% physically abused, 59% African American, 41% Caucasian) enrolled in a metropolitan-area treatment center providing an educational/intervention program for maltreated children and their families. Most (82%) of the participant families had an annual income of $10,000 or less. Parent/caregivers and teacher/ therapists provided data about the children, employing the Colorado Child Temperament Inventory, Child Behavior Checklist, and Preschool Behavior Questionnaire. The results indicate that the teacher/therapists and the parent/caregivers perceived the same child as behaving differently. Implications concerning how teachers and parents might communicate are discussed, as well as possible reasons for the two different perceptions of the same child. Three potential reasons for the differences are that they are due to the different perspectives of parents and teachers in assessing child behaviors, to situational variation in child behavior (e.g., home versus school), or to some combination of both effects.     

On becoming neutral: effects of experimental neutralizing reconsidered

Behaviour Research and Therapy 34 (1996) 889–898 found that writing out a negative thought produced anxiety and an urge to neutralize the thought, that instructing participants to neutralize the thought reduced anxiety/neutralization urge in the short run (i.e. within 2 min), but that in the control group 20 min without instruction was attended by the same reduction in anxiety/urge to neutralize (“natural decay”). The observations were made with pariticipants who scored high on “thought action fusion” and the experiment was set up as exerimental model of obsessions. We repeated the study with participants that were not selected on thought action fusion. All the findings reported by Behaviour Research and Therapy 34 (1996) 889–898 were replicated. Correlational analysis indicated that the strength of the effect was not related to scores on scales measuring “thought action fusion”. Behaviour Research and Therapy 34 (1996) 889–898 did not assess whether non-neutralizing was followed by immediate reductions in distress. We did assess this and found that the larger part of the immediate reduction of distress after neutralization also occurs when no neutralization instruction is given. The effects of neutralization instructions in the present type of experiment are considerably less powerful than suggested earlier.     

Women helping chewers: partner support and smokeless tobacco cessation.

Data from 363 male smokeless tobacco users and their romantic partners were analyzed to discern the role of support in cessation. Women reported playing a part in enrollment (71%), and more than half examined program materials or discussed cessation activities with the chewers. Women's reports of delivered support correlated substantially with men's experience of received support. Men's received positive support predicted abstinence at 6-month follow-up (odds ratio = 1.29, confidence interval = 1.03-1.61) and more than 24 hr of abstinence for those still using tobacco at 6 months (odds ratio = 1.75, confidence interval = 1.30-2.36) and moderated the effect of baseline depression and addiction on abstinence. Women played a major role through all stages of cessation.     

Sentential structure and the perceptual spans of two samples of disabled readers

The constructs of accuracy and speed were adopted as performance criteria against which to define two clinical samples of disabled readers. Accuracy-disabled subjects had failed to achieve reliable age-appropriate word recognition skills. Rate-disabled readers were age-appropriate in word recognition accuracy but deficient on measures of contextual accuracy and reading speed. When their eye-voice spans were measured under different text manipulations, accuracy-disabled and rate-disabled children differed in the magnitude of their perceptual spans during the act of reading. The two samples did not differ in the extent to which they availed themselves of contextual constraints to extend their spans in the reading of connected text. Both samples of disabled readers appeared able to use syntactic information as an independent source of sentential information in reading, even the sample whose reading disability was associated with oral syntax deficits. Comparisons with a previous sample of normal beginning readers suggested both types of disabled readers to be reading with perceptual spans of reduced dimensions.This research was supported by operating funds from the Medical Research Council of Canada, the Ontario Mental Health Foundation/COMSOC Provincial Lottery Grants Program, and The Hospital for Sick Children Foundation. The author gratefully acknowledges the generous contributions of Terry Smialy and Judy Millington in assisting with all phases of data collection and data analysis. Special thanks are due Judy Millington for her skill in computing and analyzing the phrase boundary and pseudoboundary counts. Identification of the present rate-disabled subjects was made possible through the assistance of Andrew Biemiller, Donald G. Doehring, and Roger T. Lennon, who made previously unpublished normative data on reading speed available for use in this research project. The generosity of these individuals is very gratefully acknowledged. This paper was presented in part to the annual meeting of the American Psychological Association, Anaheim, California, August 1983.     

Implementing a long-term computerized remedial reading program with synthetic speech feedback: Hardware,software, and real-world issues

This paper discusses hardware choices, software developments, implementation issues, and preliminary results from an ongoing long-term remedial reading study. Reading-disabled children read books on microcomputers linked to speech synthesizers, obtaining speech feedback on difficult words at whole-word, syllable, or subsyllable levels of segmentation. Word-recognition ability and attitude about reading improved for children using the system. In addition, segmented feedback especially benefited phonological word-decoding skills for most of the children.