Patients’ Opinions on Genetic Counseling on the Increased Risk of Parkinson Disease among Gaucher Disease Carriers

Gaucher disease (GD) is an autosomal recessive disease caused by GBA mutations that is especially common in the Ashkenazi Jewish (AJ) population. The link between GBA mutations and Parkinson disease (PD), a later-onset neurodegenerative condition, is well established, and studies have shown that GBA carriers have an increased lifetime risk of developing PD. Carrier screening for GD is frequently offered to couples during or prior to pregnancy, especially to those of AJ descent. However, no studies have been performed to assess if prospective parents would want to learn about their risk of developing PD incidentally through carrier screening. It is also unknown if pre-test counseling on this topic would affect screening uptake. In order to answer these questions, a survey was administered to individuals who screened negative for GBA mutations. Of the 75 participants, 86.7% believed that patients should be informed about the increased risk of PD prior to having GD carrier screening, and 93.3% responded that this information would not have changed their decision to have carrier screening. These results indicate that healthcare providers should take into consideration patient preferences when determining how to counsel about GD carrier screening. Additionally, these results have implications for genetic counseling about other later-onset conditions that may be incidentally ascertained through carrier screening.     

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Ruminative thinking is related to an increased risk for major depressive disorder (MDD) and perpetuates negative mood states. Rumination, uncontrollable negative thoughts about the self, may comprise both reflective and brooding components. However, only brooding rumination is consistently associated with increased negativity bias and negative coping styles, while reflective rumination has a less clear relationship with negative outcomes in healthy and depressed participants. The current study examined seed-to-voxel (S2.V) resting-state functional connectivity (FC) in a sample of healthy (HC) and depressed (MDD) adult women (HC: n=50, MDD: n=33). The S2V FC of six key brain regions, including the left and right amygdala, anterior and posterior cingulate cortex (ACC, PCC), and medial and dorsolateral prefrontal cortices (mPFC, dlPFC), was correlated with self-reported reflective and brooding rumination. Results indicate that HC and MDD participants had increased brooding rumination associated with decreased FC between the left amygdala and the right temporal pole. Moreover, reflective rumination was associated with distinct FC of the mPFC, PCC, and ACC with parietal, occipital, and cingulate regions. Depressed participants, compared with HC, exhibited decreased FC between the PCC and a region in the right middle frontal gyrus. The results of the current study add to the understanding of the neural underpinnings of different forms of self-related cognition—brooding and reflective rumination—in healthy and depressed women.     

Assessing Future Expectations of Low-Income Minority Young Men: Survival-Threats and Positive Expectations

Future expectations, a subset of overall orientation, represent youths’ most realistic appraisals of future outcomes, and has been demonstrated to be associated with a range of health risk behaviors and wellbeing. The current study extends previous measurement efforts to operationalize and measure future expectations by estimating a multidimensional model of future expectations encompassing both positive and survival-based expectations, and using longitudinal data to test the consistency of these constructs over time. The current work uses data from six waves of the Chicago Youth Development Study (n = 338), a sample of African American and Latino young men from low income neighborhoods in an urban center, to test a hypothesized multidimensional structure of future expectations across adolescence. Test retest confirmatory factor analyses from six waves of data covering the mean age range of 12–19 years reveal good model fit for the hypothesized multidimensional model of future expectations at each wave. Strong measurement invariance based on race/ethnicity is established for the multidimensional model. Implications for a latent construct approach to future expectations with low-income racial/ethnic minority young men are discussed.     

Effects of occupational future time perspective on managing stressful work situations

According to the socioemotional selectivity theory (SST; Carstensen, 2006), older adults perceive their future time as increasingly limited, which motivates them to focus more on emotional goals and prefer passive emotion‐focused strategies. This study aims to investigate the effect of occupational future time perspective (OFTP) on the use of problem‐solving strategies in stressful work situations and to examine the effectiveness of these strategies on psychological well‐being. A sample of 199 Chinese clerical workers responded to a structured questionnaire on problem‐solving strategy use in relation to hypothetical work scenarios. Results revealed that relative to those with limited OFTP, workers with expansive OFTP preferred problem‐focused and proactive strategies in both low‐ and high‐emotionally salient scenarios. Workers with limited OFTP consistently preferred passive strategies irrespective of emotional salience. OFTP moderated the effect of problem‐focused strategies on psychological distress. In particular, there was a significant negative relationship between problem‐focused strategies and psychological distress among workers with expansive OFTP, but such pattern of relationship was not observed among workers with limited OFTP. Findings of this study inform the training strategies employed by practitioners to fit the developmental goals of workers in order to maximise their strengths at work.