Medication barriers and anti-hypertensive medication adherence: the moderating role of locus of control

Locus of control as a moderator of the relationship between medication barriers (e.g., side-effects, forgetting to take medication, and keeping track of pills) and anti-hypertensive medication adherence was examined. Baseline data were obtained from 588 hypertensive veterans. In general, fewer medication barriers, higher internal locus of control and lower external locus of control was associated with better hypertensive medication adherence. Furthermore, internal locus of control served as a moderator (beta = -.74, p < .01) for the relationship between medication barriers and medication adherence; effect size was large. Decomposition of the interaction revealed that the relationship between medication barriers and medication adherence was strongest when internal control was high (b = -.24, p < .01). Higher internal locus of control was beneficial when barriers to medication adherence are low, but at high perceived barriers, locus of control plays less of a role in medication adherence. Future efforts to improve medication adherence should consider the patient's perceived level of medication barriers in conjunction with their locus of control.     

(Physio)logical circuits: the intellectual origins of the McCulloch-Pitts neural networks

This article examines the intellectual and institutional factors that contributed to the collaboration of neuropsychiatrist Warren McCulloch and mathematician Walter Pitts on the logic of neural networks, which culminated in their 1943 publication, "A Logical Calculus of the Ideas Immanent in Nervous Activity." Historians and scientists alike often refer to the McCulloch-Pitts paper as a landmark event in the history of cybernetics, and fundamental to the development of cognitive science and artificial intelligence. This article seeks to bring some historical context to the McCulloch-Pitts collaboration itself, namely, their intellectual and scientific orientations and backgrounds, the key concepts that contributed to their paper, and the institutional context in which their collaboration was made. Although they were almost a generation apart and had dissimilar scientific backgrounds, McCulloch and Pitts had similar intellectual concerns, simultaneously motivated by issues in philosophy, neurology, and mathematics. This article demonstrates how these issues converged and found resonance in their model of neural networks. By examining the intellectual backgrounds of McCulloch and Pitts as individuals, it will be shown that besides being an important event in the history of cybernetics proper, the McCulloch-Pitts collaboration was an important result of early twentieth-century efforts to apply mathematics to neurological phenomena.     

One- and two-year prospective follow-up of cognitive behavior therapy or supportive psychotherapy

We followed up over 90% of 57 motor vehicle accident survivors, who completed a controlled comparison of cognitive behavioral therapy (CBT) to supportive psychotherapy (SUPPORT). One-year results showed a continued significant advantage on categorical diagnosis (PTSD or not) and structured interview measures (CAPS) for CBT over SUPPORT. Other measures generally showed the same results. At two years, we were able to follow-up only 75% of one-year completers. Although there continued to be arithmetic differences favoring CBT over SUPPORT, with these attenuated samples only differences on PTSD Checklist and Impact of Event Scale scores and in overall categorical diagnoses were significant. There was very modest improvement from end of treatment to the two-year follow-up.     

Self-esteem and memory

This article describes two potential bases for memory bias associated with global self-esteem. According to the mood-congruence model, activation of either dimension of self-esteem (self-competence or self-liking) produces an affective state that facilitates retrieval of traces that are consistent with that state while hindering retrieval of traces that are inconsistent. According to the relevance model, activation of either dimension results in superior encoding of matching negative content by individuals who are low on the dimension. Three studies were conducted to determine which model best accounts for the pattern of bias across distinct content categories. Results were generally consistent with the relevance model.     

Unwanted and unfollowed: Defining ghosting and the role of social media unfollowing

Ghosting involves terminating communication, including through technological mediums, as a means of ending a relationship. Despite attention from popular media, empirical examinations of this breakup strategy are sparse. Using a correlational design, we examined the defining features of ghosting including its associations with other breakup tactics, whether it is an exclusively unilateral strategy, and the role of social media unfollowing in its implementation. A convenience sample of primarily undergraduate students (n = 260) completed an online survey describing recent breakups, indicating the disengagement tactics used, social media unfollowing, and the extent to which the breakups involved ghosting. Findings indicated that ghosting is extremely common, it was used to terminate more than half of participants' recent relationships. Most participants had experienced a breakup involving ghosting as either the disengager and/or the recipient. Ghosting was found to involve less open confrontation, more avoidance/withdrawal and de-escalation tactics. Contrary to previous research, ghosting can occur bilaterally, with partners ghosting each other. Social media unfollowing is an important aspect of ghosting. Relationships ended via ghosting have fewer post-breakup connections than those ended through other strategies. Typically, ghosters initiate social media unfollowing. Findings provide insight into how ghosting should be conceptualized and measured in future explorations.     

Psychometric properties of the children's atypical development scale

The Children's Atypical Development Scale (CADS) is a 53-item rating scale designed to measure unusual behaviors in children. Principal-factor analysis on a clinic-referred and pediatric sample of 474 children resulted in a four-factor solution: Communication Deficits, Lability, Social Relatedness Deficits, and Preoccupation. The CADS is internally consistent and has adequate temporal stability. CADS factor scores were differentially associated with parent and teacher rating scales, IQ, and Continuous Performance Test errors. The scale shows promise as a clinical and research tool for assessing atypical behaviors associated with pervasive developmental disorder and other neurobehavioral disorders.This research was supported in part by a grant from the Smart Family Foundation. The authors are grateful to James P. O'Donnell, Catherine Lord, and Frank A. Zelko for their comments on an earlier draft.     

Token-mediated tool-use by a tufted capuchin monkey (Cebus apella)

This research examined token-mediated tool-use in a tufted capuchin monkey (Cebus apella). We conducted five experiments. In experiment 1 we examined the use of plastic color-coded chips to request food, and in experiments 2–5 we examined the use of color-coded chips to request tools. Our subject learned to use chips to request tools following the same general pattern seen in great apes performing analogous tasks, that is, initial discrimination followed by an understanding of the relationship among tokens, tools, and their functions. Our findings are consistent with the view that parallel representational processes underlie the tool-related behavior of capuchins and great apes. Received: 11 March 1998 / Accepted after revision: 19 August 1998     

Genetic Knowledge Among Participants in the Coriell Personalized Medicine Collaborative

Genetic literacy is essential for the effective integration of genomic information into healthcare; yet few recent studies have been conducted to assess the current state of this knowledge base. Participants in the Coriell Personalized Medicine Collaborative (CPMC), a prospective study assessing the impact of personalized genetic risk reports for complex diseases and drug response on behavior and health outcomes, completed genetic knowledge questionnaires and other surveys through an online portal. To assess the association between genetic knowledge and genetic education background, multivariate linear regression was performed. 4 062 participants completed a genetic knowledge and genetic education background questionnaire. Most were older (mean age: 50), Caucasian (90 %), female (59 %), highly educated (69 % bachelor’s or higher), with annual household income over $100 000 (49 %). Mean percent correct was 76 %. Controlling for demographics revealed that health care providers, participants previously exposed to genetics, and participants with ‘better than most’ self-rated knowledge were significantly more likely to have a higher knowledge score (p?<?0.001). Overall, genetic knowledge was high with previous genetic education experience predictive of higher genetic knowledge score. Education is likely to improve genetic literacy, an important component to expanded use of genomics in personalized medicine.     

Prevalence of Cognitively Intact Individuals Residing in Extended Care Nursing Facilities

There appears to be a relative absence of studies that have examined the prevalence of cognitively intact individuals who reside in extended care facilities. Prevalence data were collected on 296 persons who resided in 3 extended care nursing facilities in Central Virginia. Cognitive intactness was evaluated via the Minimum Data Set Cognitive Performance Scale (CPS) and an author-generated survey (i.e., Cognitively Intact Survey [CI Survey]) of select nursing staff members at each facility. The Mini-Mental State Examination (MMSE) was utilized to examine the accuracy of the two measures in identifying cognitive intactness. Findings indicated that prevalence rates of cognitively intact residents varied as a function of the measures utilized to assess intactness. Specifically, a significantly greater proportion of the total sample of residents was judged to be cognitively intact via the CI Survey (34.12%) as compared to the CPS (26.01%). The level of interjudge agreement between the two measures was found to be moderately high (K = 0.68). When the MMSE was employed to verify individuals' levels of intactness, the percentages of residents predicted to actually be cognitively intact were somewhat lower for each measure. Specifically, based on the data obtained via the CI Survey, 22.75% of the total sample were predicted to actually be cognitively intact, whereas 17.85% of the sample were predicted to be intact based on the CPS results. Findings are discussed in light of factors that may have contributed to the differential prevalence rates of cognitively intact individuals obtained across the measures utilized in this study. Concerns regarding the utilization of the MMSE as a criterion measure of cognitive intactness in persons residing in extended care nursing facilities are provided, along with data on the living environments/roommate statuses of those residents judged to be intact via the CI Survey. Implications for the design of future extended care nursing units, as well as future research, are also included.