The role of inhibition in the regulation of sequential action

We investigated the regulation of sequential action using a new paradigm. Participants learned a sequence of seven stimulus categories and then monitored for them during successive displays. All displays were instances of these categories, presented in pseudorandom order. On each trial, participants monitored for an instance of Category 1, pressed a key on a computer keyboard, then monitored for an instance of Category 2, pressed a key on the keyboard, and so on for all seven categories. Thus, a perfect trial contained exactly seven responses. Intrusion errors were classified as a function of ordinal distance from the current serial position ( n ). Fewer intrusion errors were made at near serial positions than at far ones, suggesting a gradient of lateral inhibition. In addition, more intrusions were made on n + 1 categories than n − 1 categories, suggesting greater availability of intended than completed goals. In accord with current models of sequential action, the results indicate lateral and self-inhibition as important mechanisms in regulation of sequential action.     

A preferential matching problem

A matching method proposed by Dr. C. E. Stuart is presented in some detail and the essentials for a test of significance are derived. This method differs from the older matching methods in that partial credit is allowed for a near miss. A slight variation of the method permits the matching of one item withM sets ofn traits.     

Simultaneous visual discrimination in Asian elephants

Two experiments explored the behavior of 20 Asian elephants (Elephas aximus) in simultaneous visual discrimination tasks. In Experiment 1, 7 Burmese logging elephants acquired a white+/black- discrimination, reaching criterion in a mean of 2.6 sessions and 117 discrete trials, whereas 4 elephants acquired a black+/white- discrimination in 5.3 sessions and 293 trials. One elephant failed to reach criterion in the white+/black- task in 9 sessions and 549 trials, and 2 elephants failed to reach criterion in the black+/white- task in 9 sessions and 452 trials. In Experiment 2, 3 elephants learned a large/small transposition problem, reaching criterion within a mean of 1.7 sessions and 58 trials. Four elephants failed to reach criterion in 4.8 sessions and 193 trials. Data from both the black/white and large/small discriminations showed a surprising age effect, suggesting that elephants beyond the age of 20 to 30 years either may be unable to acquire these visual discriminations or may require an inordinate number of trials to do so. Overall, our results cannot be readily reconciled with the widespread view that elephants possess exceptional intelligence.     

Goal congruency in bimanual object manipulation

In 3 experiments, the authors investigated the impact of action goals on the production of discrete bimanual responses. Similar to a bartender putting 2 glasses simultaneously on a shelf, participants placed 2 objects into either parallel or opposite orientations by carrying out either mirror-symmetrical or mirror-asymmetrical movements. In Experiment 1, performance was strongly affected by the congruency of the intended object orientations but was essentially unaffected by movement symmetry. Experiment 2 replicated this instrumental goal-congruency effect (and the absence of motor-symmetry effects) when actions were cued in advance. Experiment 3 revealed substantial motor-symmetry effects, provided the movements themselves became the action goal. The authors concluded that performance in bimanual choice reaction tasks is constrained by the creation and maintenance of goal codes rather than by properties inherent in the neuromuscular system that carries out these responses. These goals can relate to either body-intrinsic states or to body-extrinsic states according to the actor's current intentions.     

APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder

Animal models are considered essential in research ensuing elucidation of human disease processes and subsequently, testing of potential therapeutic strategies. This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible in human patients. Alzheimer's disease is vastly becoming a major medical and socioeconomic problem in our aging society. Valid animal models for this uniquely human condition should exhibit histopathological, biochemical, cognitive, and behavioral alterations observed in Alzheimer's disease patients. Major progress has been made since the understanding of the genetic basis of Alzheimer's disease and the development and improvement of transgenic mouse models. All present Alzheimer's disease models developed are partial but nevertheless essential in further unraveling the nature and spatial and temporal development of the complex molecular pathology underlying this condition. One of the more recent transgenic attempts to model Alzheimer's disease is the APP23 transgenic mouse. This article describes the development and assessment of this human amyloid precursor protein overexpression model. We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice, thereby emphasizing the model's contribution to clarification of neurodegenerative disease mechanisms. In addition, the first therapeutic interventions in the APP23 model are included.     

Psychoanalytische Therapie

A statement of the professional umbrella society DGPT is presented that was formulated in cooperation with the various professional societies and with the German Society of Psychosomatic Medicine and Psychotherapy and the Society of Child and Adolescent Therapy. The statement is a reaction to the public claim for effective evidence of psychotherapy and takes the opportunity for a comprehensive presentation of this field. In the introduction Alf Gerlach, as chairman of the umbrella society at the time of the formulation of this statement and now executive chairman responsible for coordinating research, describes the history of the development of the statement.There were two particular moments prompting this statement. On the one hand the Scientific Advisory Board for Psychotherapy as an advisory committee based on the law of psychotherapy, has presented demands for effective evidence that are incompatible with psychoanalysis. Thus, the recognition of psychoanalysis as a treatment method for illnesses was put in doubt. On the other hand, a suggestion was put forward to the Board to recognize psychodynamic psychotherapy as an independent entity. This questioned the unity of the psychotherapeutic field.The statement was passed onto the Scientific Advisory Board last autumn. It is intended for a professional audience and includes answers to important issues of this field. It will have an important role to play in future discussions about professional politics. For this reason, we have decided to begin the present issue of our journal with this statement and thus to open a wide discussion forum.

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Deutsche Gesellschaft für Psychoanalyse, Psychotherapie, Psychosomatik und Tiefenpsychologie e.V. (DGPT)In Verbindung mit:Deutsche Gesellschaft für Analytische Psychologie (DGAP)Deutsche Gesellschaft für Individualpsychologie (DGIP)Deutsche Gesellschaft für Psychotherapeutische Medizin (DGPM)Deutsche Psychoanalytische Gesellschaft (DPG)Deutsche Psychoanalytische Vereinigung (DPV)Vereinigung Analytischer Kinder- und Jugendlichen-Psychotherapeuten (VAKJP)Redaktion: Stephan Hau und Marianne Leuzinger-Bohleber

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Memory accessibility, mood regulation, and dysphoria: difficulties in repairing sad mood with happy memories?

Recent studies have suggested that mood-incongruency effects are due to mood-regulatory processes, in which people retrieve positive memories to repair negative moods. In Study 1, the authors investigated whether dysphoria influences the accessibility of autobiographical memories following a positive or a negative mood induction combined with subsequent rumination or distraction. The results showed a mood-repair effect for nondysphoric but not for dysphoric participants following rumination. In Study 2, participants were asked to either distract themselves or to recall positive autobiographical memories after a negative mood induction. Whereas nondysphoric participants' mood improved under both conditions, dysphoric participants' mood improved only after distraction. These results suggest that dysphoria is associated with a reduced ability to use mood-incongruent recall to repair sad moods.