Psychometric instability of measures in novel settings: Use of psychiatric rating scales in nursing homes

Researchers have become increasingly concerned about problems of the quality of measurement in applied evaluation settings. Of particular importance is change in both the reliability and the validity of a measure that is used in a novel setting. This problem is illustrated by an attempt to use psychiatric rating scales to assess the behavior of chronic mental patients currently residing in nursing homes. Methods for assessing changes in both reliability and validity are presented, along with suggestions for how to deal with these problems.This research was supported in part by an Extramural Research Grant from the State of Illinois Department of Mental Health and Developmental Disabilities.     

Philosophical aspects of Maoist thought

Mao has responded to the challenge of adapting Marxism to traditional Chinese thought through his two ‘creative developments’ of Marxism: the ideological definition of class and the concept of permanent revolution, based on intra-personal class-struggle.     

I wish it were true: Confessions of a secret deductivist

The criticisms by S. V. Paunonen and D. N. Jackson (1985, Journal of Research in Personality, 19, 331–342) are examined in detail. Despite the best of intentions, the author remains unconvinced.     

Working with Research Integrity—Guidance for Research Performing Organisations: The Bonn PRINTEGER Statement

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on the following key issues:

1. § 1.
   Providing information about research integrity
    
2. § 2.
   Providing education, training and mentoring
    
3. § 3.
   Strengthening a research integrity culture
    
4. § 4.
   Facilitating open dialogue
    
5. § 5.
   Wise incentive management
    
6. § 6.
   Implementing quality assurance procedures
    
7. § 7.
   Improving the work environment and work satisfaction
    
8. § 8.
   Increasing transparency of misconduct cases
    
9. § 9.
   Opening up research
    
10. § 10.
    Implementing safe and effective whistle-blowing channels
     
11. § 11.
    Protecting the alleged perpetrators
     
12. § 12.
    Establishing a research integrity committee and appointing an ombudsperson
     
13. § 13.
    Making explicit the applicable standards for research integrity
     

     

Biases in multilevel analyses caused by cluster-specific fixed-effects imputation

When datasets are affected by nonresponse, imputation of the missing values is a viable solution. However, most imputation routines implemented in commonly used statistical software packages do not accommodate multilevel models that are popular in education research and other settings involving clustering of units. A common strategy to take the hierarchical structure of the data into account is to include cluster-specific fixed effects in the imputation model. Still, this ad hoc approach has never been compared analytically to the congenial multilevel imputation in a random slopes setting. In this paper, we evaluate the impact of the cluster-specific fixed-effects imputation model on multilevel inference. We show analytically that the cluster-specific fixed-effects imputation strategy will generally bias inferences obtained from random coefficient models. The bias of random-effects variances and global fixed-effects confidence intervals depends on the cluster size, the relation of within- and between-cluster variance, and the missing data mechanism. We illustrate the negative implications of cluster-specific fixed-effects imputation using simulation studies and an application based on data from the National Educational Panel Study (NEPS) in Germany.     

Simultaneous motor demands affect decision making under objective risk

Previous studies on factors influencing decision making focused on the effects of additional cognitive load, stress, psychological disorders, and the process of aging. The potential effects of simultaneously performing motor demands have been neglected, so far. However, previous motor / cognitive dual-task studies provide evidence for both negative as well as facilitating effects of simultaneously performing cognitive and motor tasks. The study at hand, aimed to investigate the effects of decision making under objective risk while performing additional motor demands. Seventy-two participants ranging from 18 to 30 years performed the Game of Dice Task either while sitting or while standing on one leg. Participants were asked to put similar effort on the decision task and the motor demand. The results revealed a significant main effect for “choice”, as well as a significant interaction of “choice”?×?“group”. Participants standing on one leg more frequently selected the most disadvantageous choice (one single number), whereas the “sitting group” most often selected the advantageous combination of four numbers. The findings are discussed under the aspects of executive functions, working memory, stress, somatic markers and the dual-process theory.     

Response-retrieval and negative priming

The existence of across-notation automatic numerical processing of two-digit (2D) numbers was explored using size comparisons tasks. Participants were Arabic speakers, who use two sets of numerical symbols—Arabic and Indian. They were presented with pairs of 2D numbers in the same or in mixed notations. Responses for a numerical comparison task were affected by decade difference and unit-decade compatibility and global distance in both conditions, extending previous findings with Arabic digits (Nuerk, Weger, & Willmes, 2001). Responses for a physical comparison task were affected by congruency with the numerical size, as indicated by the size congruency effect (SiCE). The SiCE was affected by unit-decade compatibility but not by global distance, thus suggesting that the units and decades digits of the 2D numbers, but not the whole number value were automatically translated into a common representation of magnitude. The presence of similar results for same- and mixed-notation pairs supports the idea of an abstract representation of magnitude.     

Health-related quality of life in Parkinson's disease after pallidotomy and deep brain stimulation

This study explored the multidimensional outcome of three neurosurgical interventions for Parkinson's disease (PD): pallidotomy (N = 23), pallidal deep brain stimulation (DBS) (N = 9), and thalamic DBS (N = 7). All patients completed the Sickness Impact Profile (SIP) and the Beck Depression Inventory. Pallidotomy patients also completed the Profile of Mood States, the Beck Anxiety Inventory, and a disease-specific quality of life (QOL) measure, the Parkinson's Disease Questionnaire (PDQ-39). Three months after surgery, all neurosurgical groups showed significant improvements in mood and function, including physical, psychosocial, and overall functioning. Pallidal DBS and pallidotomy patients who completed additional QOL measures reported decreased anxiety and tension, increased vigor, improved mobility and ability to perform activities of daily living, and decreased perceived stigma. Psychosocial dysfunction scores from the SIP were related to depressed mood both at baseline (r = .42) and at followup (r = .45), but the physical dysfunction subscale was not related to mood at either time point, suggesting that disruption of social relationships due to PD may have more impact on affective distress than physical symptoms alone. Results suggest that neurosurgical interventions for PD improve disabling PD motor symptoms and also improve several domains of quality of life.     

Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment

Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease (AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse model of AD. We also assessed brain content of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). Performance was alike in wild-type and APP23 animals in the radial maze. In contrast, performance in the complex maze was better in wild-type than APP23 animals. Contrary to the wild-type, hippocampal BDNF levels decreased on training in APP23 animals. Hippocampal and frontal cortex NGF levels in APP23 animals correlated with the time to solve the complex maze, but correlated inversely with escape time in wild-type animals. NT-3 levels were alike in wild-type and APP23 animals and were unchanged even after training. Both types of mazes depend on hippocampal integrity to some extent. However, according to the cognitive mapping theory of spatial learning, the complex maze because of the increased complexity of the environment most likely depends more strongly on preserved hippocampal function than the radial maze in the working memory configuration applied here. Greater impairment in complex maze performance than in radial maze performance thus resembles the predominant affliction of the loss of hippocampal function in human AD. NGF and BDNF levels on maze learning are different in wild-type and transgenic animals, indicating that biological markers of AD may be altered on challenge even though equilibrium levels are alike.     

Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial

Dialectical Behavioral Therapy (DBT) was initially developed and evaluated as an outpatient treatment program for chronically suicidal individuals meeting criteria for borderline personality disorder (BPD). Within the last few years, several adaptations to specific settings have been developed. This study aims to evaluate a three-month DBT inpatient treatment program. Clinical outcomes, including changes on measures of psychopathology and frequency of self-mutilating acts, were assessed for 50 female patients meeting criteria for BPD. Thirty-one patients had participated in a DBT inpatient program, and 19 patients had been placed on a waiting list and received treatment as usual in the community. Post-testing was conducted four months after the initial assessment (i.e. four weeks after discharge for the DBT group). Pre-post-comparison showed significant changes for the DBT group on 10 of 11 psychopathological variables and significant reductions in self-injurious behavior. The waiting list group did not show any significant changes at the four-months point. The DBT group improved significantly more than participants on the waiting list on seven of the nine variables analyzed, including depression, anxiety, interpersonal functioning, social adjustment, global psychopathology and self-mutilation. Analyses based on Jacobson's criteria for clinically relevant change indicated that 42% of those receiving DBT had clinically recovered on a general measure of psychopathology. The data suggest that three months of inpatient DBT treatment is significantly superior to non-specific outpatient treatment. Within a relatively short time frame, improvement was found across a broad range of psychopathological features. Stability of the recovery after one month following discharge, however, was not evaluated and requires further study.