Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment

Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease (AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse model of AD. We also assessed brain content of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). Performance was alike in wild-type and APP23 animals in the radial maze. In contrast, performance in the complex maze was better in wild-type than APP23 animals. Contrary to the wild-type, hippocampal BDNF levels decreased on training in APP23 animals. Hippocampal and frontal cortex NGF levels in APP23 animals correlated with the time to solve the complex maze, but correlated inversely with escape time in wild-type animals. NT-3 levels were alike in wild-type and APP23 animals and were unchanged even after training. Both types of mazes depend on hippocampal integrity to some extent. However, according to the cognitive mapping theory of spatial learning, the complex maze because of the increased complexity of the environment most likely depends more strongly on preserved hippocampal function than the radial maze in the working memory configuration applied here. Greater impairment in complex maze performance than in radial maze performance thus resembles the predominant affliction of the loss of hippocampal function in human AD. NGF and BDNF levels on maze learning are different in wild-type and transgenic animals, indicating that biological markers of AD may be altered on challenge even though equilibrium levels are alike.     

Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial

Dialectical Behavioral Therapy (DBT) was initially developed and evaluated as an outpatient treatment program for chronically suicidal individuals meeting criteria for borderline personality disorder (BPD). Within the last few years, several adaptations to specific settings have been developed. This study aims to evaluate a three-month DBT inpatient treatment program. Clinical outcomes, including changes on measures of psychopathology and frequency of self-mutilating acts, were assessed for 50 female patients meeting criteria for BPD. Thirty-one patients had participated in a DBT inpatient program, and 19 patients had been placed on a waiting list and received treatment as usual in the community. Post-testing was conducted four months after the initial assessment (i.e. four weeks after discharge for the DBT group). Pre-post-comparison showed significant changes for the DBT group on 10 of 11 psychopathological variables and significant reductions in self-injurious behavior. The waiting list group did not show any significant changes at the four-months point. The DBT group improved significantly more than participants on the waiting list on seven of the nine variables analyzed, including depression, anxiety, interpersonal functioning, social adjustment, global psychopathology and self-mutilation. Analyses based on Jacobson's criteria for clinically relevant change indicated that 42% of those receiving DBT had clinically recovered on a general measure of psychopathology. The data suggest that three months of inpatient DBT treatment is significantly superior to non-specific outpatient treatment. Within a relatively short time frame, improvement was found across a broad range of psychopathological features. Stability of the recovery after one month following discharge, however, was not evaluated and requires further study.     

Selective attention, inhibition for repeated events and hemispheric specialization

When two visual events appear consecutively in the same spatial location, our response to the second event is slower than to the first. This inhibition for repeated events may reflect a bias toward sampling novel locations, a bias useful for exploring visual space. It has been shown that the left hemisphere is more specialized in selective attentional processes than the right one. The aim of the present experiment was to test if this hemispheric specialization for selective attention may also affect the inhibition for repeated events. For this purpose, we asked 11 normal subjects to perform an identity-based discrimination task in which the target to be detected could appear alone or surrounded by flanking letters, in the left or in the right visual field. Results show that inhibition for repeated events is present only when selective attention is required and when the task is performed in the right specialized visual field.     

Contextual information modulates initial processes of syntactic integration: the role of inter- versus intrasentential predictions

The authors demonstrate that intersentential context may influence syntactic integration processes during online sentence comprehension, although this influence appears to be restricted to cases in which a contextual requirement must be fulfilled. By applying event-related brain potentials to the processing of clause-medial word order variations in German, the authors show that the local processing difficulty (a negativity from 300 to 450 ms) observed for object-initial sentences in a neutral context is also obtained in a (behaviorally) facilitating context in which the object is contextually given. By contrast, the processing pattern for a focused (questioned) initial object does not differ from that for a focused subject: both elicit a parietal positivity (280-480 ms) post-onset of the focused phrase. The authors interpret this early positivity as a general marker of focus integration, a process that appears to briefly supersede sentence-internal requirements.     

Assumptions and consequences of treating providers in therapy studies as fixed versus random effects: reply to Crits-Christoph, Tu, and Gallop (2003) and Serlin, Wampold, and Levin (2003)

In their comments on the authors' article, R. C. Serlin, B. E. Wampold, and J. R. Levin and P. Crits-Christoph, X. Tu, and R. Gallop took issue with the authors' suggestion to evaluate therapy studies with nested providers with a fixed model approach. In this rejoinder, the authors' comment on Serlin et al's critique by showing that their arguments do not apply, are based on misconceptions about the purpose and nature of statistical inference, or are based on flawed reasoning. The authors also comment on Crits-Christoph et al's critique by showing that the proposed approach is very similar to, but less inclusive than, their own suggestion.     

Power and measures of effect size in analysis of variance with fixed versus random nested factors

Ignoring a nested factor can influence the validity of statistical decisions about treatment effectiveness. Previous discussions have centered on consequences of ignoring nested factors versus treating them as random factors on Type I errors and measures of effect size (B. E. Wampold & R. C. Serlin). The authors (a) discuss circumstances under which the treatment of nested provider effects as fixed as opposed to random is appropriate; (b) present 2 formulas for the correct estimation of effect sizes when nested factors are fixed; (c) present the results of Monte Carlo simulations of the consequences of treating providers as fixed versus random on effect size estimates, Type I error rates, and power; and (d) discuss implications of mistaken considerations of provider effects for the study of differential treatment effects in psychotherapy research.     

Quantifiers and Congruence Closure

We prove some results about the limitations of the expressive power of quantifiers on finite structures. We define the concept of a bounded quantifier and prove that every relativizing quantifier which is bounded is already first-order definable (Theorem 3.8). We weaken the concept of congruence closed (see [6]) to weakly congruence closed by restricting to congruence relations where all classes have the same size. Adapting the concept of a thin quantifier (Caicedo [1]) to the framework of finite structures, we define the concept of a meager quantifier. We show that no proper extension of first-order logic by means of meager quantifiers is weakly congruence closed (Theorem 4.9). We prove the failure of the full congruence closure property for logics which extend first-order logic by means of meager quantifiers, arbitrary monadic quantifiers, and the Härtig quantifier (Theorem 6.1).     

The Diachronic Coherence of Ungraded Beliefs

This paper works within a model of ungraded belief that characterizes epistemic states as logically closed and consistent sets of sentences. The aim of this paper is to discuss three diachronic coherence conditions for such beliefs. These coherence conditions are formulated in terms of the reasoner's present beliefs about how his present beliefs will evolve in the future, for instance, in response to different pieces of future evidence.     

The Coherence Argument Against Conditionalization

I re-examine Coherence Arguments (Dutch Book Arguments, No Arbitrage Arguments) for diachronic constraints on Bayesian reasoning. I suggest to replace the usual game–theoretic coherence condition with a new decision–theoretic condition ('Diachronic Sure Thing Principle'). The new condition meets a large part of the standard objections against the Coherence Argument and frees it, in particular, from a commitment to additive utilities. It also facilitates the proof of the Converse Dutch Book Theorem. I first apply the improved Coherence Argument to van Fraassen's (1984) Reflection principle. I then point out the failure of a Coherence Argument that is intended to support Conditionalization as a naive, universal, update rule. I also point out that Reflection is incompatible with the universal use of Conditionalization thus interpreted. The Coherence Argument therefore defeats the naive view on Bayesian learning that it was originally designed to justify. This revised version was published online in August 2006 with corrections to the Cover Date.     

Stability of National-Identity Content: Level,Predictors, and Implications

A neglected topic in empirical research on national identity is its stability at the individual level, and this is especially true for its content, that is, the meaning elements that people associate with the concept of nation. In this article, we study the stability of key dimensions of national-identity content. We ask three simple questions: How stable is national-identity content—as captured in the ethnic/civic framework—at the level of individual citizens? Are there clear differences in stability across subgroups? What are the implications of interindividual differences in stability? Analyzing data from four waves of a large-scale panel survey of German citizens (N = 4,654) collected over a five-year period (2016–21), we show that there is high but not perfect stability of the degree to which individuals subscribe to ethnic and civic criteria of nationhood. Second, we find little difference in stability as a function of several theoretically selected characteristics. Third, we show that the association between national-identity content and relevant political attitudes (immigration attitudes and far-right party support) increases with intraindividual stability. These findings have important implications for our understanding of how national-identity content is shaped and mobilized and how it can influence political attitudes and behaviors.