Associative learning impairments in patients with frontal lobe damage

The performance of 18 frontal lobe lesion (FL) and 10 frontal lobe dementia (FLD) patients on an associative memory test was compared with the performance of their matched normal controls. The FL group was severely impaired on cued and free recall and was moderately impaired on a recognition condition. Left FL patients performed the poorest on the cued and free recall conditions. The FLD patients were moderately impaired on the free recall condition only but there was a subgroup of FLD patients with additional left temporal atrophy who appeared severely impaired on both cued and free recall. These findings indicate that both left frontal and temporal lobe damage can impair associative learning and that this impairment is more strikingly seen with free rather than cued recall.     

Priming effects in attentional gating

Three experiments were conducted to determine the effects of amount of prior target information (Experiment 1) and semantic priming (Experiment 2) in an attentional gating task. The goal was to determine some causes of the processing deficits commonly observed in perceiving successive visual stimuli. Items in a rapid serial visual presentation (RSVP) stream are subject to processing deficits before they are processed to the level of recognition (early selection) and after they have been recognized (late selection). Deficits in the former case presumably are due to an early filter that prevents complete recognition and semantic analysis, whereas deficits in the latter case arise from interference or response competition, producing forgetting among a set of recognized items. The semantic-priming effects found between a cue and a target (Experiment 2) and between two successive targets (Experiment 3) indicate that top-down processes can increase the subjective availability of related items. The results are consistent with the idea that most processing deficits observed in search through an RSVP sequence are due to limited capacity in our ability to form episodic representations of all the items in the sequence.     

Perceptual interference decays over short unfilled intervals

The perceptual interference effect refers to the fact that object identification is directly related to the amount of information available at initial exposure. The present article investigated whether perceptual interference would dissipate when a short, unfilled interval was introduced between exposures to a degraded object. Across three experiments using both musical and pictorial stimuli, identification performance increased directly with the length of the unfilled interval. Consequently, significant perceptual interference was obtained only when the interval between exposures was relatively short (< 500 msec for melodies; < 300 msec for pictures). These results are consistent with explanations that attribute perceptual interference to increased perceptual noise created by exposures to highly degraded objects. The data also suggest that perceptual interference is mediated by systems that are not consciously controlled by the subject and that perceptual interference in the visual domain decays more rapidly than perceptual interference in the auditory domain.     

Search Strategies in Syntactic Reanalysis

We first consider the nature of syntactic reanalysis, paying particular attention to questions about whether and how it differs from the construction of an initial analysis, such as whether it is encapsulated or whether alternatives are considered in parallel or not. We then outline different strategies that the processor may use in reanalysis, and review the relevant evidence. We show that our experimental evidence is compatible with an encapsulated serial search strategy.     

Monozygotic twins with Asperger syndrome: differences in behaviour reflect variations in brain structure and function

A pair of monozygotic twins discordant for symptoms of Asperger syndrome was evaluated at the age of 13.45 years using psychometric, morphometric, behavioural, and functional imaging methods. The lower-functioning twin had a smaller brain overall, a smaller right cerebellum, and a disproportionately large left frontal lobe, and manifested almost no differential activation between distractors of high and low-congruence with target visual stimuli. The higher-functioning twin manifested a typically autistic pattern of anterior deactivation and posterior hyperactivation in response to incongruent distractors, overlaid with a typically normal pattern of activation of superior frontal cortex. The morphometric results are consistent with known correlations between brain structure and behaviour in autism, and the physiological results suggest correspondences between structure and function.     

Belief in the inevitability of suicide: results from a national survey

To examine public opinion regarding the effectiveness of means restriction as an approach to preventing suicide we asked a national sample of 2,770 respondents a hypothetical question about what effect a suicide barrier might have had on the ultimate fate of the more than 1,000 people who have jumped to their death from the Golden Gate Bridge. Thirty-four percent of respondents believed that every single jumper would have found another way to complete suicide and an additional 40% believed that "most" would have completed suicide using other means. The strongest predictors of belief in complete substitution were firearm ownership and cigarette smoking. Belief in the inevitability of suicide may be a political impediment to adopting potentially effective suicide prevention efforts.     

An ethics perspective on transcranial magnetic stimulation (TMS) and human neuromodulation

This paper concerns the ethics of human neuromodulation using transcranial magnetic stimulation (TMS). We examine the challenges of modulating the brain with TMS through the research ethics lens and in clinical medicine for treating frank pathology, primarily in psychiatric diseases. We also consider contemporary issues raised in the neuroethics literature about managing unexpected findings, and relate these to TMS and to other frontier neurotechnology that is becoming openly available in the public domain. We argue that safety and informed consent are of paramount importance for TMS, but that personal values and sociocultural factors must also be considered when examining the promise of this technology and applications that ought to be highlighted for extra precautions.