STUDIES IN THE PSYCHOLOGICAL EFFECTS OF A NEW DRUG (DIETHYLPROPION): Subjective effects in the natural environment

Two doses diethylpropion, one dose pipradrol, one dose amobarbital and placebo were administered to 116 subjects, who rated their state on twenty variables. The variables were intercorrelated under pipradrol and pentymal. The correlation matrices were subjected to factor analysis. Four factors were found in both studies: Happiness, Alertness, Relaxation, and Flight of thoughts. There is some agreement between the two factor analyses. There were few significant effects of the drugs on factor scores, but the structure is quite unambiguous: pipradrol and diethylpropion are stimulating, and amobarbital tranquilizing.     

Dissociations between procedural and episodic memory: effects of time and aging

The issue of multiple memory systems is explored. Young and older adults (mean ages = 20 and 71, respectively) named pictures and were tested immediately, 1, 7, or 21 days later. Episodic memory (recognition) for pictures was significantly lower in older relative to young adults and declined systematically across all retention intervals in both age groups. In contrast, procedural memory (repetition priming in picture naming) revealed no reliable age differences. In both age groups, priming declined within the first 24 hr, but unlike recognition, there was no further decrement from 1 to 21 days. There were also within-subject dissociations: The magnitude of priming was equivalent for remembered and forgotten items, and the relation between recognition and priming across intervals was nonmonotic, revealing a reversed association. The findings were interpreted within a multiple-memory-systems framework.