Dietary restraint moderates genetic risk for binge eating

Dietary restraint is a prospective risk factor for the development of binge eating and bulimia nervosa. Although many women engage in dietary restraint, relatively few develop binge eating. Dietary restraint may increase susceptibility for binge eating only in individuals who are at genetic risk. Specifically, dietary restraint may be a behavioral exposure factor that activates genetic predispositions for binge eating. We investigated this possibility in 1,678 young adolescent and adult same-sex female twins from the Minnesota Twin Family Study and the Michigan State University Twin Registry. Twin moderation models were used to examine whether levels of dietary restraint moderate genetic and environmental influences on binge eating. Results indicated that genetic and nonshared environmental factors for binge eating increased at higher levels of dietary restraint. These effects were present after controlling for age, body mass index, and genetic and environmental overlap among dietary restraint and binge eating. Results suggest that dietary restraint may be most important for individuals at genetic risk for binge eating and that the combination of these factors could enhance individual differences in risk for binge eating.     

Testing the role of adolescent sexual initiation in later-life sexual risk behavior: a longitudinal twin design

The consistent association between adolescent sexual initiation (ASI) and risky adult sexual behavior (RASB) has generally been assumed to indicate that ASI has a causal effect on RASB; consequently, it is assumed that delaying ASI will reduce RASB. Yet the ASI-RASB association might be better accounted for by some third variable. We evaluated the causal role of ASI (initiation of oral, anal, or vaginal sex at or before age 16) in influencing RASB in a longitudinal sample of 2,173 twins (followed from ages 11 to 24 or from ages 17 to 29) using two methods: the discordant-twin design and the propensity-score design. The former controlled for unmeasured genetic and shared environmental factors, and the latter controlled for measured nonshared environmental factors. We replicated the link between ASI and RASB reported in previous research, but results from the discordant-twin and propensity-score analyses suggested that this association is better explained by common genetic or environmental risk factors than as a causal effect. These findings suggest that preventing ASI is unlikely to reduce RASB.     

The Relationship between Parent-Child Conflict and Adolescent Antisocial Behavior: Confirming Shared Environmental Mediation

Prior studies have indicated that the relationship between parent-child conflict and adolescent antisocial behavior is at least partially shared environmental in origin. However, all available research on this topic (to our knowledge) relies exclusively on parent and/or adolescent informant-reports, both of which are subject to various forms of rater bias. As the presence of significant shared environmental effects has often been attributed to rater bias in the past (Baker et al. Journal of Abnormal Psychology 16:219–235, 2007; Bartels et al. Journal of the American Academy of Child and Adolescent Psychiatry 42:1351–1359, 2003, Twin Research 7:162–175, 2004; Hewitt et al. Behavior Genetics 22:293–317, 1992), it would be important to confirm that findings of shared environmental mediation persist when even examining (presumably more objective) observer-ratings of these constructs. The current study thus examined the origins of the relationship between parent-child conflict and adolescent acting-out behavior, as measured using both observer-ratings and various informant-reports. Participants included 1,199 adopted and non-adopted adolescents in 610 families from the Sibling Interaction and Behavior Study (SIBS). Results indicated that parent-child conflict consistently predicts acting-out behavior in adopted adolescents, and moreover, that this association is equivalent to that in biologically-related adolescents. Most importantly, these findings did not vary across parent- and adolescent-reported or observer-ratings of parent-child conflict and acting-out behavior. Such findings argue strongly against rater bias as a primary explanation of shared environmental mediation of the association between parent-child conflict and adolescent antisocial behavior.     

Genetic relationships between personality and eating attitudes and behaviors

Genetic and environmental factors underlying relationships between personality traits and disordered eating were examined in 256 female adolescent twin pairs (166 monozygotic, 90 dizygotic). Eating behaviors were assessed with the Total Score, Body Dissatisfaction, Weight Preoccupation, Binge Eating, and Compensatory Behavior subscales from the Minnesota Eating Disorders Inventory (M-EDI; K. L. Klump, M. McGue, & W. G. Iacono, 2000). Personality characteristics were assessed with the Negative Emotionality, Positive Emotionality, and Constraint scales from the Multidimensional Personality Questionnaire (MPQ; A. Tellegen, 1982). Model-fitting analyses indicated that although genetic factors were more likely to contribute to MPQ and M-EDI phenotypic associations than environmental factors, shared genetic variance between the 2 phenotypes was limited. MPQ personality characteristics may represent only some of several genetic risk factors for eating pathology.     

An assessment of sleep architecture as a function of degree of handedness in college women using a home sleep monitor

The present study examined sleep architecture as a function of handedness in a population of undergraduate college women using a home sleep monitor. Compared to strongly handed individuals, participants with a tendency toward mixed-handedness had a shorter sleep latency and spent a greater percentage of their sleep period asleep and less awake. Increasing mixed-handedness was also associated with increased NREM; strong-handedness was associated with increased REM. Results are placed in a neurophysiological framework wherein corpus callosum mediated differences in interhemispheric interaction during Wake, REM, and NREM on the one hand, and individual differences in corpus callosum morphology and hemispheric communication as a function of handedness on the other, interact to result in handedness differences in sleep architecture.     

The effects of psychological therapies under clinically representative conditions: a meta-analysis

Recently, concern has arisen that meta-analyses overestimate the effects of psychological therapies and that those therapies may not work under clinically representative conditions. This meta-analysis of 90 studies found that therapies are effective over a range of clinical representativeness. The projected effects of an ideal study of clinically representative therapy are similar to effect sizes in past meta-analyses. Effects increase with larger dose and when outcome measures are specific to treatment. Some clinically representative studies used self-selected treatment clients who were more distressed than available controls, and these quasi-experiments underestimated therapy effects. This study illustrates the joint use of fixed and random effects models, use of pretest effect sizes to study selection bias in quasi-experiments, and use of regression analysis to project results to an ideal study in the spirit of response surface modeling.     

Intensional Completeness in an Extension of Gödel/Dummett Logic

We enrich intuitionistic logic with a lax modal operator and define a corresponding intensional enrichment of Kripke models M = (W, , V) by a function T giving an effort measure T(w, u) {} for each -related pair (w, u). We show that embodies the abstraction involved in passing from true up to bounded effort to true outright. We then introduce a refined notion of intensional validity M |= p : and present a corresponding intensional calculus iLC-h which gives a natural extension by lax modality of the well-known G: odel/Dummett logic LC of (finite) linear Kripke models. Our main results are that for finite linear intensional models L the intensional theory iTh(L) = {p : | L |= p : } characterises L and that iLC-h generates complete information about iTh(L).Our paper thus shows that the quantitative intensional information contained in the effort measure T can be abstracted away by the use of and completely recovered by a suitable semantic interpretation of proofs.     

"La manie d'ecrire": psychology, auto-observation, and case history

This essay examines the modern psychiatric case study as a scientific method and as a genre of writing about the self. As psychological discourse became a privileged language of selfhood at the fin de siècle, the penultimate signifier of the self came to be found in the realm of sexuality, in the particular contours of an individual's sexual desire. The investigative tool used to uncover these secrets of identity was the case history. This article concerns an influential project of sexual research based on "auto-observations"-autobiographical patient narratives-conducted by Dr. Georges Saint-Paul, who published under the inverted pseudonym "Laupts." The article focuses on the central autobiography of his collection, the "roman d'un inverti," and related sexological literature to suggest how this emphasis on patient stories in psychiatric writing engendered new narrative possibilities for doctors and patients alike. Putting patient stories at the center of psychiatric investigation created a new relationship between patient and doctor, observation and diagnosis, subject and discourse. The tools of psychological observation simultaneously placed a subject's confession more firmly at the center of the investigation and made it more open to interpretation by nonspecialists. Rather than simply confirming the authority of the trained observer, the story of Laupts's enquête suggests that the method actually authorized inquiry by others.     

Can We Use Hare’s Psychopathy Model within Forensic and Non-Forensic Populations? An Empirical Investigation

Although psychopathy construct (Self-Report Psychopathy Scale–Short Form [SRP–SF]) was assessed among various samples, prior research did not investigate whether the model proposed by Hare and colleagues can be used to capture psychopathy scores derived from forensic and nonforensic populations. The main objective of the current study was to test dimensionality, construct validity, and factorial invariance of the SRP–SF within prison (n = 730) and student (n = 2,506) samples. Our results indicate that the SRP–SF measure cannot be used in the same way within forensic and nonforensic samples, which may be due to the inclusion of criminal/antisocial traits as an integral part of psychopathy.