Cytokines and memory across the mature life span of women

Increasing evidence suggests a role of the immune system in modulation of cognition, but details on affected memory systems are largely lacking. We therefore aimed to study the relation between selected cytokines and subsets of memory, and the impact of age in these relations. From a random population-based sample (the Betula Prospective Cohort Study), 298 women (age 45-90) were studied in terms of episodic recall and recognition, semantic fluency and knowledge, and prospective memory. Circulating cytokines of relevance for cognition and aging were measured with ELISA. Levels of interleukin (IL)-6 and sIL-2R were significantly and negatively associated with most cognitive variables, while the opposite was true for IL-1β. Age shared substantial variance with both cytokines and memory, and turned most correlations non-significant when controlled for together with education, BMI and presence of disease. Interactions between age and cytokines were further analyzed in multiple regressions. For IL-6, significant negative interactions with age were found for semantic fluency (p<0.05) and prospective memory (p<0.01), and for sIL-2R in predicting semantic knowledge (p<0.05), indicating an increased negative impact of these cytokines on memory with increasing age. In conclusion, the study indicates a relation between cytokines and memory that appears to be largely mediated by age, and supports the suggestion that cytokine dysregulation with higher age may interact with cognitive aging.     

Dichotic listening and otoacoustic emissions: shared variance between cochlear function and dichotic listening performance in adults with normal hearing

The present study investigated a possible connection between speech processing and cochlear function. Twenty-two subjects with age range from 18 to 39, balanced for gender with normal hearing and without any known neurological condition, were tested with the dichotic listening (DL) test, in which listeners were asked to identify CV-syllables in a nonforced, and also attention-right, and attention-left condition. Transient evoked otoacoustic emissions (TEOAEs) were recorded for both ears, with and without the presentation of contralateral broadband noise. The main finding was a strong negative correlation between language laterality as measured with the dichotic listening task and of the TEOAE responses. The findings support a hypothesis of shared variance between central and peripheral auditory lateralities, and contribute to the attentional theory of auditory lateralization. The results have implications for the understanding of the cortico-fugal efferent control of cochlear activity.     

Arousal enhanced memory retention is eliminated following temporal lobe resection

The amygdala, situated in the anterior medial temporal lobe (MTL), is involved in the emotional enhancement of memory. The present study evaluated whether anterior MTL-resections attenuated arousal induced memory enhancement for pictures. Also, the effect of MTL-resections on response latencies at retrieval was assessed. Thirty-one patients with unilateral MTL-resections (17 left, 14 right) together with 16 controls participated in a forced choice memory task with pictorial stimuli varying in arousal. Response latencies increased with stimulus arousal in controls but not in patients. This was paralleled by attenuated recognition memory for moderately and highly arousing pictures in MTL-resectioned patients as compared to healthy controls. However, patients and controls did not differ in memory performance for non-arousing pictures. These results suggest that the MTL is necessary for arousal induced memory enhancement.     

Disruption of writing by background speech: Does sound source location and number of voices matter?

It is not unusual that people have to write in an environment where background speech is present. Background speech can vary in both speech intelligibility and location of the sound source. Earlier research has shown disruptive effects of background speech on writing performance. To expand and reinforce this knowledge, the present study investigated the role of number of voices and sound source location in the relation between background speech and writing performance. Participants wrote texts in quiet or in background speech consisting of one or seven voices talking simultaneously located in front of or behind them. Overall, one voice was more disruptive than seven voices talking simultaneously. Self‐reports showed that sound from the front was more disruptive compared with sound from behind. Results are in line with theory of interference‐by‐process, attentional capture, and the cross‐modal theory of attention. The relevance of the results for open‐office environments is discussed.     

Mediators of Change in Cognitive Behavior Therapy for Clinical Burnout

Evidence supporting the effectiveness of cognitive behavior therapy (CBT) for stress-related illness is growing, but little is known about its mechanisms of change. The aim of this study was to investigate potential mediators of CBT for severe stress in form of clinical burnout, using an active psychological treatment as comparator. We used linear mixed models to analyze data from patients (N = 82) with clinical burnout who received either CBT or another psychological treatment in a randomized controlled trial. Potential mediators (i.e., sleep quality, behavioral activation, perceived competence, and therapeutic alliance) and outcome (i.e., symptoms of burnout) were assessed weekly during treatment. The results showed that the positive treatment effects on symptoms of burnout favoring CBT (estimated between-group d = 0.93) were mediated by improvements in sleep quality, ab = -0.017, 95% CI_asymmetric [-0.037, -0.002], and increase in perceived competence, ab = -0.037, 95% CI_asymmetric [-0.070, -0.010]. Behavioral activation, ab = -0.004 [-0.016, 0.007], and therapeutic alliance, ab = 0.002 [-0.006, 0.011], did not significantly mediate the difference in effects between the treatments. Improving sleep quality and increasing perceived competence may thus constitute important process goals in order to attain symptom reduction in CBT for clinical burnout.     

Turning failures into successes: a methodological shortcoming in empirical research on surrogate accuracy

Decision making for incompetent patients is a much-discussed topic in bioethics. According to one influential decision making standard, the substituted judgment standard, a surrogate decision maker ought to make the decision that the incompetent patient would have made, had he or she been competent. Empirical research has been conducted in order to find out whether surrogate decision makers are sufficiently good at doing their job, as this is defined by the substituted judgment standard. This research investigates to what extent surrogates are able to predict what the patient would have preferred in the relevant circumstances. In this paper we address a methodological shortcoming evident in a significant number of studies. The mistake consists in categorizing responses that only express uncertainty as predictions that the patient would be positive to treatment, on the grounds that the clinical default is to provide treatment unless it is refused. We argue that this practice is based on confusion and that it risks damaging the research on surrogate accuracy.

An inexpensive and accurate method of measuring the force of responses in reaction time research

Together with reaction time (RT), the force with which people respond to stimuli can provide important clues about cognitive and affective processes. We discuss some of the issues surrounding the accurate measurement and interpretation of response force, and present a response key by which response force can be measured regularly and unobtrusively in RT research. The advantage of the response key described is that it operates like a standard response key of the type used regularly in classic RT experiments. The construction of the response key is described in detail and its potential assessed by way of an experiment examining response force in a simple reaction task to visual stimuli of increasing brightness and size.     

An interaction model for odor quality and intensity

The perceived intensity and quality of binary odor mixtures are studied in relation to bow their components are perceived when presented separately. Subjects judged the perceived intensity and quality of 6 concentrations of pyridine, 6 concentrations ofn-butanol, and their 36 possible combinations. The results show that the perceived intensity of the mixture can be predicted from the perceived intensity of its components presented separately (R _A andR _B) by the Euclidian arithmetic model. The maximum probability of identifying a mixture as a “mixture” is reached whenR _A andR _B are equally strong. An interaction model for mixtures that relates perceived intensity and quality is presented and tested. The test reveals that both the perceived intensity of a mixture and the probability that it will be identified as the one or the other component can, by a simple interaction model, be successfully predicted fromR _A andR _B.     

The effects of women's age and physical appearance on evaluations of attractiveness and social desirability.

Younger people are perceived as possessing a host of socially desirable attributes, some of which are the same traits attributed to attractive people. In the present study, 160 younger and older White Canadians rated the attractiveness and personality traits of 1 of 4 target women. The results indicated an interaction between the participant's age and gender and the age and attractiveness of the target person. Both younger and older judges showed an attractiveness bias and downrated the social desirability of younger unattractive targets. Younger judges rated younger and older attractive targets as equal in social desirability. Older male judges rated older attractive targets as less socially desirable than younger attractive targets. Results are discussed in terms of cultural expectations of beauty.