The treatment of neuropathic pain

Neuropathic pain is responsible for a significant amount of the morbidity associated with generalized and focal peripheral neuropathies. It is a consequence of alterations in neuronal function, chemistry, and structure that occur secondary to nerve injury. These manifestations of neuronal plasticity occur in the peripheral nerve, spinal cord, and brain. A variety of agents from diverse pharmacologic classes, the so-called adjuvant analgesics, have been used to treat neuropathic pain. These include antidepressants, first- and second-generation anticonvulsants, antiarrhythmic agents, topical agents, N-methyl-D-aspartate receptor antagonists, and opioid analgesics. The use of these adjuvant analgesics, either alone or in combination, should result in the alleviation of neuropathic pain in most patients. Recent advances in the understanding of pain mechanisms at multiple central nervous system levels should pave the way toward more effective treatment modalities.     

When does word meaning affect immediate serial recall in semantic dementia?

Patients with semantic dementia can show superior immediate recall of words that they still understand relatively well, as compared with more semantically degraded words, suggesting that conceptual knowledge makes a major contribution to phonological short-term memory. However, a number of studies have failed to show such a recall difference, challenging this view. We examined the effect of several methodological factors on the recall of known and degraded words in 4 patients with semantic dementia, in order to investigate possible reasons for this discrepancy. In general, our patients did exhibit poorer recall of the degraded words and made more phonological errors on these items. In addition, set size affected the magnitude of the recall advantage for known words. This finding suggests that semantic degradation influenced the rate of learning in the immediate recall task when the same items were presented repeatedly. The methods used to select known and degraded items also impacted on the recall difference. List length, however, did not affect the advantage for known words. The coherence of items in phonological short-term memory was affected by their semantic status, but not by the length of the material to be retained. The implications of these findings for the role of semantic and phonological representations in verbal short-term memory are discussed.     

Sex differences for selective forms of spatial memory

In the present study, a systematic comparison of sex differences for several tests of spatial memory was conducted. Clear evidence for more accurate male performance was obtained for precise metric positional information in a wayfinding task and in an object location memory task. In contrast, no sex difference characterized topological information processing (object-to-position assignment). Together, these findings provide further insight in the specificity of sex differences in spatial memory and in the functional architecture of spatial memory. Implications for the relevant evolutionary basis are discussed.     

Bilingualism and adult differences in inhibitory mechanisms: evidence from a bilingual stroop task

The present investigation examined the functioning of inhibitory mechanisms in younger and older bilinguals using a bilingual version of the Stroop test. The study predicted different patterns of age related decline in inhibitory mechanisms (inter- and intralingual interference) in bilinguals depending on their level of proficiency. Consistent with expectations, older bilinguals were slower when they responded in their non-dominant language. Furthermore, older unbalanced bilinguals showed greater interlingual interference when they responded with their second language to visual stimuli written in their dominant language. Balanced bilinguals showed equivalent interference effects between all conditions. These findings suggest that manipulating two languages may enhance the efficiency of inhibitory mechanisms.     

Too proud to let go: narcissistic entitlement as a barrier to forgiveness

Narcissistic entitlement impedes forgiveness in ways not captured by other robust predictors (e.g., offense severity, apology, relationship closeness, religiosity, Big Five personality factors), as demonstrated in 6 studies. Narcissistic entitlement involves expectations of special treatment and preoccupation with defending one's rights. In Study 1, entitlement predicted less forgiveness and greater insistence on repayment for a past offense. Complementary results emerged from Study 2, which used hypothetical transgressions, and Study 3, which assessed broad forgiveness dispositions. Study 4 examined associations with the Big Five, and Study 5 extended the findings to a laboratory context. Study 6 demonstrated that entitlement predicted diminished increases in forgiveness over time. Taken together, these results suggest that narcissistic entitlement is a robust, distinct predictor of unforgiveness.     

Social exclusion and the deconstructed state: time perception, meaninglessness, lethargy, lack of emotion, and self-awareness

The authors hypothesize that socially excluded individuals enter a defensive state of cognitive deconstruction that avoids meaningful thought, emotion, and self-awareness, and is characterized by lethargy and altered time flow. Social rejection led to an overestimation of time intervals, a focus on the present rather than the future, and a failure to delay gratification (Experiment 1). Rejected participants were more likely to agree that "Life is meaningless" (Experiment 2). Excluded participants wrote fewer words and displayed slower reaction times (Experiments 3 and 4). They chose fewer emotion words in an implicit emotion task (Experiment 5), replicating the lack of emotion on explicit measures (Experiments 1-3 and 6). Excluded participants also tried to escape from self-awareness by facing away from a mirror (Experiment 6).     

Intellectual performance and ego depletion: role of the self in logical reasoning and other information processing

Some complex thinking requires active guidance by the self, but simpler mental activities do not. Depletion of the self's regulatory resources should therefore impair the former and not the latter. Resource depletion was manipulated by having some participants initially regulate attention (Studies 1 and 3) or emotion (Study 2). As compared with no-regulation participants who did not perform such exercises, depleted participants performed worse at logic and reasoning (Study 1), cognitive extrapolation (Study 2), and a test of thoughtful reading comprehension (Study 3). The same manipulations failed to cause decrements on a test of general knowledge (Study 2) or on memorization and recall of nonsense syllables (Study 3). Successful performance at complex thinking may therefore rely on limited regulatory resources.     

A linear optical trajectory informs the fielder where to run to the side to catch fly balls

P. McLeod, N. Reed, and Z. Dienes (2002) argued that the linear optical trajectory (LOT) strategy incorrectly cues fielders to run forward for balls headed beyond them. The authors of this article explain that the downward optical curvature found for balls landing beyond the fielder's initial position occurs because the balls reorient the direction the fielder is facing during pursuit. Thus, when downward optical curvature begins, the ball is headed to land in front of where the fielder is facing and running. This investigation of open-loop failure conditions has led to new insights such as the reorientation of the fielder, and it supports the use of maintaining matching rates of vertical and lateral optical ball movement consistent with primacy of the LOT control mechanism even when interception is unachievable.     

Transient manic behavior after pallidotomy

We report two cases of transient hypomanic behavior following pallidotomy. Both of the reported patients had lesions involving non-motor portions of the globus pallidus. Patient 1 had a lesion in the left anteromedial portion of GPi, while patient 2 had one lesion involving the anteromedial portion of GPi on the right and a second lesion involving the postero-ventral most portion of the putamen on the left. These cases emphasize the importance of placing lesions within the sensori-motor portion of GPi without infringing on adjacent non-motor portions. Cases involving transient manic behavior after pallidotomy have not been previously reported. Centers performing pallidotomy or DBS should be aware that lesions or stimulation too anterior in the GPi might lead to manic behavior.     

Preservation of autobiographical memory in a case of pure progressive amnesia

G.D., a 79 year-old female, presents with a severe and slowly progressive amnesia although she remains entirely independent in daily life and is perfectly well spatially oriented. Her amnesia is relatively isolated and her deficit does not embrace other cognitive domains. G.D. underwent extensive neuropsychological evaluation including language, executive functions, perceptual, and memory tests. Based on clinical observation, the purpose of this study was to determine whether there was a dissociation between her autobiographical and semantic memory. Results point out a severely degraded semantic knowledge of famous public events and persons while autobiographical memory of personally experienced and relevant information remains intact. Results from this study and from previous studies seem to suggest that relative sparing of hippocampal structures may be related to the preservation of autobiographical memory.