Glutamate-hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a pathologic feature of certain mood and anxiety disorders that results in the increased production and secretion of corticotropin-releasing factor. There is increasing preclinical evidence that glutamate, an excitatory amino acid, plays an important role in the regulation of the HPA axis. Activation of glutamatergic projections to limbic structures such as the amygdala and brainstem structures such as the nucleus tractus solitarius is implicated in the stress response. There are laboratory and clinical suggestions that glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonists function as antidepressants, and that chronic antidepressant treatments have a significant impact on NMDA receptor function. Clinical investigations of glutamate antagonists in patients with mood and anxiety disorders are in their infancy, with a few reports suggesting the presence of mood-elevating properties. Ultimately, HPA axis modulators, serotonin-enhancing agents, and glutamate antagonists might serve to increase neurotropic factors in key brain regions for affective and anxiety regulation, providing a putative final common pathway.     

Orientation tuning of shape from shading

Four experiments were performed to assess the effect of different orientations and direction of lighting on the visual processing of shaded or bipartite disks. In the first two experiments, observers were presented with nine different shading orientations from 0 degree to 180 degrees. Targets were detected in a rapid and parallel fashion for shaded disks when the orientation of the shading gradient was not horizontal (90 degrees) or oriented at 67.5 degrees. Search asymmetries favoring the detection of "pock" targets over "ball" targets were found for all orientations. The search rates for bipartite disks were similar to the shaded disks at 0 degree, 22.5 degrees, and 90 degrees but not for intermediate orientations, and no search asymmetries were found. These differences suggest that shaded displays and bipartite displays are processed by different underlying mechanisms. The third experiment showed that the direction of the light source (left or right) had no influence on search asymmetries around the 90 degrees point. Shading gradient orientation affected magnitude estimates of depth in the fourth experiment. These experiments show that the visual system's "assumption" of overhead lighting is broadly tuned.     

Human trafficking: factors that influence willingness to combat the issue

Human trafficking involves severe violations of human rights and social action is required to combat it. Past research has identified emotional reactions to victims of trafficking, as well as the perceived cost and efficacy of actions, as significant predictors of willingness to get involved. We surveyed 216 Australians (70% female) to assess their perceptions of sex and labor trafficking and actions to reduce them. Results demonstrated that women reported greater personal distress (but not empathy) for victims than men, which was associated with greater willingness to take action. Women also perceived available actions to be more efficacious than men, which predicted willingness, while perceived cost of actions did not. Implications for promoting social action to reduce human trafficking are discussed.     

A Global Happiness Scale for Measuring Wellbeing: A Test of Immunity Against Hedonism

Wellbeing is gaining acceptance as an indicator of social and economic progress by many governments and agencies. As such the scientific community is actively engaging in developing scales to gauge wellbeing at a community and national level. A common approach used comprises of asking subjects a single question on happiness. A major issue with single questions is the difficulty to establish reliability. Recognising this issue, researchers have developed an itemised Global Happiness Scale (GHS) comprising of four items. GHS is reported to have satisfactory reliability and convergent validity and the scale has been translated into a number of different languages. However to ensure GHS is measuring happiness at a global level, that is measuring eudaimonic happiness, it is necessary to ensure it is immune to hedonic happiness. GHS had not been previously subjected to a hedonic immunity test, which the current study addressed. This paper reports and discusses the reliability and hedonic immunity of GHS.     

The Effect of Non-Stroke Cardiovascular Disease States on Risk for Cognitive Decline and Dementia: A Systematic and Meta-Analytic Review

Cardiovascular disease is associated with increased risk for cognitive decline and dementia, but it is unclear whether this risk varies across disease states or occurs in the absence of symptomatic stroke. To examine the evidence of increased risk for cognitive decline and dementia following non-stroke cardiovascular disease we conducted two independent meta-analyses in accordance with PRISMA guidelines. The first review examined cardiovascular diagnoses (atrial fibrillation, congestive heart failure, periphery artery disease and myocardial infarction) while the second review assessed the impact of atherosclerotic burden (as indicated by degree of stenosis, calcification score, plaque morphology or number of plaques). Studies eligible for review longitudinally assessed risk for clinically significant cognitive decline and/or dementia and excluded stroke and cognitive impairment at baseline. Summary statistics were computed via the inverse variance weighted method, utilising Cox Proportional Hazards data (Hazard Ratios, HR). Both atrial fibrillation (n = 5, HR = 1.26, 95% CI [1.12, 1.43]) and severe atherosclerosis (n = 4, HR = 1.59, 95% CI [1.12, 2.26]) emerged as significant risk factors for cognitive decline and/or dementia. A small set of studies reviewed, insufficient for meta-analysis, examining congestive heart failure, peripheral artery disease and myocardial infarction suggested that these conditions may also be associated with an increased risk of cognitive decline/dementia. In the absence of stroke, patients with atrial fibrillation or generalised atherosclerosis are at heightened risk for cognitive deterioration. Nonetheless, this paper highlights the need for methodologically rigorous and prospective investigation of the relationship between CVD and dementia.     

Principle‐Based Integrative Therapy with Couples: Theory and a Case Example

The Principle‐Based Integrative Therapy (PBIT) framework harnesses the principles of change underlying each theoretical model within integrative couple therapy treatments. PBIT has commonalities with other integrative approaches, and additional advantages stemming from its four tenets that guide therapists in combining strengths across models and overcoming each of their deficiencies. Tenet 1 advises that each model adds a core principle or mechanism of action that other models do not automatically address. Tenet 2 focuses on how techniques of one model may actualize the principles of other models. Tenet 3 ensures complementarity and a lack of conflict across principles. A case study and common case considerations are presented to illustrate how Tenets 1–3 can work in integrating Cognitive‐Behavioral, Multicultural, and Emotionally Focused Therapy models in working with a couple. Finally, Tenet 4 advocates for the use of models and empirically supported principles that also have received empirical support with diverse populations. Prerequisites and training implications for PBIT, and future clinical and research directions to further the utility of PBIT are discussed.     

Mitigation system threat partially mediates the effects of right‐wing ideologies on climate change beliefs

Research consistently shows that right‐wing ideological adherents are more likely to deny climate change. However, less is known about how right‐wing ideological subtypes are uniquely related to climate change denial, as well as what explains these relationships. This study examines whether threat to the socioeconomic system in the form of climate change mitigation policies, referred to as Climate Change Mitigation Threat (CCMT), mediates the relationships between Right‐Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO) subtypes and four forms of climate change denial (existence denial, human cause denial, impact denial and climate science denial). U.S. participants (N = 334; M_age = 34.70, SD = 5.98) were recruited via Amazon MTurk. When shared variance in the predictors was accounted for, we found that: (a) Conventionalism (RWA‐C) positively predicted all forms of climate change denial; (b) Dominance (SDO‐D) positively predicted existence denial; (c) Anti‐Egalitarianism (SDO‐E) positively predicted both human cause and impact denial; and (d) Aggression (RWA‐A) negatively predicted existence denial. All significant direct relationships were partially mediated by CCMT, except for the direct paths between SDO‐D and existence denial, and RWA‐A and existence denial. These findings suggest that right‐wing adherents who conform to societal norms and prefer unequal social systems may deny climate change partly due to a perception that mitigation strategies proposed to combat climate change threaten the existing socioeconomic system.     

Offender-Victim Relationships in Criminal Homicide Followed by Offender's Suicide,North Carolina, 1972–1977

ABSTRACT: An analysis of 90 cases of criminal homicide followed by suicide in North Carolina, 1972 to 1977. Homicidal victim-offender relationships were investigated in regard to age, sex, race and whether victim and offender were member of the same family, friends, acquaintances, or strangers. These results were compared with victim-offender relationships in 994 criminal homicide cases in North Carolina in which offenders did not commit suicide. Married white males over 30 years were much more involved in homicide-suicide than they were in homicide alone. In these homicide-suicide cases, the victim was usually the spouse. Except for marital status, characteristics of homicide offenders who killed themselves resembled those of suicide-only individuals much more than those of homicide-only offenders. In the homicide-suicide cases, the killing of someone in close relationship to the offender, often a wife, appeared to be part of the evolving process of suicide. This clearly has implications for intervention into marital strife and also for immediate treatment of homicide offenders who kill spouses and other family members.