GOOD or BAD responder? Behavioural and neuroanatomical markers of clinical response to donepezil in dementia

We explored the neuropsychological and neuromorphometrical differences between probable Alzheimer's disease patients showing a good or a bad response to nine months treatment with donepezil. Before treatment, the neuropsychological profile of the two patient groups was perfectly matched. By the ninth month after treatment, the BAD-responders showed a decline of the MMSE score together with a progressive impairment of executive functions. A voxel-based morphometry investigation (VBM), at the time of the second neuropsychological assessment, showed that the BAD-responders had larger grey and white matter atrophies involving the substantia innominata of Meynert bilaterally, the ventral part of caudate nuclei and the left uncinate fasciculus, brain areas belonging to the cholinergic pathways. A more widespread degeneration of the central cholinergic pathways may explain the lack of donepezil efficacy in those patients not responding to a treatment that operates on the grounds that some degree of endogeneous release of acetylcholine is still available.     

The Value of Information as Ontological Pluralism

In my paper I will focus my attention on some philosophical aspects of the Information Ethics displayed by Luciano Floridi. Floridi’s Information Ethics has the methodological merit of providing the interpretation of the Informational Turn with a solid philosophical basis, the roots of which deserve a careful investigation. In this perspective, I will analyse a key question, which is essential not only from a theoretical but also from a practical (moral, political and legal) point of view, i.e. whether or not Floridi’s construction of information is consistent with a pluralistic conception of Being.     

EEG decoding of semantic category reveals distributed representations for single concepts

Achieving a clearer picture of categorial distinctions in the brain is essential for our understanding of the conceptual lexicon, but much more fine-grained investigations are required in order for this evidence to contribute to lexical research. Here we present a collection of advanced data-mining techniques that allows the category of individual concepts to be decoded from single trials of EEG data. Neural activity was recorded while participants silently named images of mammals and tools, and category could be detected in single trials with an accuracy well above chance, both when considering data from single participants, and when group-training across participants. By aggregating across all trials, single concepts could be correctly assigned to their category with an accuracy of 98%. The pattern of classifications made by the algorithm confirmed that the neural patterns identified are due to conceptual category, and not any of a series of processing-related confounds. The time intervals, frequency bands and scalp locations that proved most informative for prediction permit physiological interpretation: the widespread activation shortly after appearance of the stimulus (from 100 ms) is consistent both with accounts of multi-pass processing, and distributed representations of categories. These methods provide an alternative to fMRI for fine-grained, large-scale investigations of the conceptual lexicon.     

Exploring how the psychiatrist experiences the patient during the diagnostic evaluation: the Assessment of Clinician’s Subjective Experience (ACSE)

Phenomenology and the Cognitive Sciences -     

Extinction partially reverts structural changes associated with remote fear memory

Structural synaptic changes occur in medial prefrontal cortex circuits during remote memory formation. Whether extinction reverts or further reshapes these circuits is, however, unknown. Here we show that the number and the size of spines were enhanced in anterior cingulate (aCC) and infralimbic (ILC) cortices 36 d following contextual fear conditioning. Upon extinction, aCC spine density returned to baseline, but the enhanced proportion of large spines did not. Differently, ILC spine density remained elevated, but the size of spines decreased dramatically. Thus, extinction partially erases the remote memory network, suggesting that the preserved network properties might sustain reactivation of extinguished conditioned fear.     

Note Critiche

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Critical notes

     

Should I fetch one or the other? A study on dogs on the object choice in the bimodal contrasting paradigm

The present study assessed how dogs weigh gestural versus verbal information communicated to them by humans in transitive actions. The dogs were trained by their owners to fetch an object under three conditions: a bimodal congruent condition characterized by using gestures and voices simultaneously; a unimodal gestural condition characterized by using only gestures; and a unimodal verbal condition characterized by using only voices. An additional condition, defined as a bimodal incongruent condition, was later added, in which the gesture contrasted with the verbal command, that is, the owner indicated an object while pronouncing the name of the other object visible to dogs. In the incongruent condition, seven out of nine dogs choose to follow the gestural indication and performed above chance, two were at chance, whereas none of the dogs followed the verbal cues above chance. The dogs, as a group, performed above chance the gestural command in 73.6% of cases. The analysis of latencies in the above-mentioned four conditions exhibited significant differences. The unimodal verbal and the gestural conditions recorded a slower performance than both the bimodal incongruent and congruent conditions. No statistical differences were observed between the unimodal and bimodal conditions. Our results demonstrate that dogs, trained to respond equally well to gestural and verbal commands, choose to follow the indication provided by the gestural command than the verbal one to a significant extent in transitive actions. Furthermore, the responses to bimodal conditions were found to be quicker than the unimodal ones.     

Political Authority and Unjust Wars

Just war theory is currently dominated by two positions. According to the orthodox view (Walzer), provided that jus in bello principles are respected, combatants have an equal right to fight, regardless of the justice of the cause pursued by their state. According to “revisionists” (McMahan, Fabre) whenever combatants lack reasons to believe that the war they are ordered to fight is just, their duty is to disobey. I argue that when members of a legitimate state acting in good faith are ordered to fight, they acquire a pro‐tanto obligation to obey which does not depend for its validity on the justice of the cause being pursued. However, when the war is unjust, this obligation may be overridden, under certain conditions, by the obligation not to contribute to the unjustified killing of innocents. This is because (contra Raz) the pro‐tanto force of the duty to obey the law is best understood in terms of “presumptive”, rather than “exclusionary” reasons for action. This approach captures the insights of both the orthodox and the revisionist view, while avoiding the problems that afflict each of them.