Neocortical malformation as consequence of nonadaptive regulation of neuronogenetic sequence

Variations in the structure of the neocortex induced by single gene mutations may be extreme or subtle. They differ from variations in neocortical structure encountered across and within species in that these "normal" structural variations are adaptive (both structurally and behaviorally), whereas those associated with disorders of development are not. Here we propose that they also differ in principle in that they represent disruptions of molecular mechanisms that are not normally regulatory to variations in the histogenetic sequence. We propose an algorithm for the operation of the neuronogenetic sequence in relation to the overall neocortical histogenetic sequence and highlight the restriction point of the G1 phase of the cell cycle as the master regulatory control point for normal coordinate structural variation across species and importantly within species. From considerations based on the anatomic evidence from neocortical malformation in humans, we illustrate in principle how this overall sequence appears to be disrupted by molecular biological linkages operating principally outside the control mechanisms responsible for the normal structural variation of the neocortex. MRDD Research Reviews 6:22-33, 2000.     

Human concurrent performances: The effects of experience, instructions, and schedule-correlated stimuli

In order to investigate the effects of separate exposures to single schedules, of unique schedule-correlated stimuli, and of independency-informing instructions upon choice under concurrent variable-interval schedules, 28 human subjects were divided into eight groups. Each subject was exposed to a baseline procedure, an experimental procedure, and a return to the baseline procedure. Different combinations of these three manipulations were applied to the different groups only during the experimental phase (except for the independency-informing instructions, which were given to half of the groups at the start of training). For the group of subjects exposed to the combination of all three manipulations, the logarithms of the ratios of response frequencies tended to be linearly related to the logarithms of the ratios of reinforcement frequencies during the experimental phase. These orderly effects were not obtained with subjects in the other groups. The results suggest that human choice was well described by the generalized matching law when the three manipulations were simultaneously in effect, and that unreported differences in the use of these three procedural variables might partly account for contradictions between results in previous studies of human concurrent performance.     

Suicidal Asian patients: recommendations for treatment

I was given an opportunity to learn how suicide prevention programs are administered in the United States. Not surprisingly, treatment for suicidal patients is conducted in terms of the basic tenets of Western culture. When American therapists are seeing Asian patients, especially suicidal individuals who are regressed and show cultural characteristics, the therapists should be aware of the importance of cultural differences. This report discusses recommendations for treating suicidal Asian patients.     

Preserved Semantic Priming Effect in Alexia

BH, a left-handed patient with alexia and nonfluent aphasia, was presented with a lexical-decision task in which words and pronounceable pseudowords were preceded by semantically related or unrelated picture primes (Experiment 1). In Experiment 2, BH was given an explicit reading task using the word lists from Experiment 1. Performance on Experiment 2 disclosed severe reading deficits in both oral reading and semantic matching of the words to pictures. However, in Experiment 1, BH demonstrated a significant semantic priming effect, responding more accurately and more quickly to words preceded by related primes than by unrelated primes. The present results suggest that even in a patient with severe alexia, implicit access to semantic information can be preserved in the absence of explicit identification. The possibility of categorical gradient in implicit activation (living vs. nonliving) in BH was also discussed, which, however, needs to be clarified in the further investigation.     

Analysis of ultrasonic vocalizations emitted by residents during aggressive encounters among rats (Rattus norvegicus)

This investigation was concerned with the extent to which aggressive resident rats emit 40-70-kHz vocalizations and the effect of these signals on intruders. In Experiment 1, deafened and intact intruder males were given two encounters with resident animals. Deafened intruders engaged in a higher duration of immobile or freezing postures than intact animals. Experiment 2 indicated that the augmentation of freezing found among deafened intruders was not due to an inability to detect ultrasounds made by residents since intruders encountering devocalized resident males showed no reliable differences in specific motor patterns from intruders paired with intact residents. The results further demonstrated that 40-70-kHz vocalizations are produced almost entirely by intruding animals since there were no significant changes in occurrence of these calls when resident males were devocalized. Under the constraints of the testing procedures employed, the role of ultrasonic communication during the initial formation of agonistic relations could not be determined experimentally.     

Attitudes toward suicide in Japanese and American medical students.

The Suicide Opinion Questionnaire (SOQ) was administered to two samples of medical school students, from Japan (n = 80 males and 20 females) and the United States (n = 80 males and 20 females). A MANOVA followed by univariate tests indicated significant differences on the Right to die, Normality, and Aggression scales between Japanese and United States students, and significant gender differences on the Religion and Impulsivity scales. No gender by nationality interaction was obtained. An analysis of the individual SOQ items revealed substantial differences between Japanese and United States medical students in their views on suicide.     

Neural Responses to Partner Rejection Cues

ABSTRACT— Little is known about neural responses in the early automatic-stage processing of rejection cues from a partner. Event-related potentials (ERPs) offer a window to study processes that may be difficult to detect via behavioral methods. We focused on the N400 ERP component, which reflects the amount of semantic processing prompted by a target. When participants were primed by attachment-related contexts ("If I need help from my partner, my partner will be …"), rejection-related words (e.g., dismissing ) elicited greater N400 amplitudes than acceptance-related words (e.g., supporting ). Analyses of results for nonattachment primes suggest that these findings were not simply caused by target valence; the brain responds differentially to cues of partner rejection (vs. acceptance) in under 300 ms. Moreover, these early-stage neurophysiological responses were heightened or dampened as a function of individuals' adult attachment; women characterized by high anxiety and low avoidance showed the greatest N400 responses to cues of partner rejection (vs. acceptance).