Potentiation of the pressor response to stress by tolbutamide in dogs

Tolbutamide has previously been shown to amplify the pressor effects of “exogenous” catecholamines in conscious dogs, possibly due to sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. The objective of this study was to examine if tolbutamide also amplifies the pressor effects of “endogenous” catecholamines released during psychological stress (classical Pavlovian aversive conditioning). Experiments were conducted in β-adrenoreceptor-blocked (propranolol, 1 mg/kg, i.v.) conscious dogs (n=4) trained in classical aversive conditioning. Conditioning was accomplished by following a tone (CS+) with a 1/2 second shock; another tone (CS-) was not followed by any shock and served as control. With saline pretreatment, aversive conditioning (i.e., CS+) increased mean arterial pressure (MAP) only by approximately 4.7% when compared to CS-, whereas with tolbutamide (45 mg/kg, i.v.) pretreatment, the increase in MAP induced by CS+ beyond what was induced by the CS- (approximately 6.2%) was significantly (p<0.05) larger than that with saline pretreatment. In isolated canine femoral arterial segments (n=4), the vasoconstrictor effect of phenylephrine (an α₁-agonist) at 5×10^?6M (which was the EC₅₀ value) was amplified by 2×10^?2M of tolbutamide from 54.0±2.0% to 66.9±2.1%. In conclusion, tolbutamide amplifies the pressor effects of “endogenous” catecholamines in conscious dogs, possibly by sensitization of the α₁-adrenoreceptor-mediated vasoconstriction. This mechanism of action is novel and has not been reported with other agents.     

Yogicchakra symbols: Mirrors of the human mind/heart

This paper describes the classical understanding of the system ofchakras, or centers of spiritual energy, in tantric yoga. Eachchakra is presented in terms of its traditional understanding. Each is also discussed in the light of contemporary psychological stage theories of development, showing that thechakras can be seen as a model of spiritual development. The preoccupations, concerns, and attitudes associated with eachchakra are portrayed as a mirror of the human mind/heart when spiritual energy is concentrated at that location.She is also founder and chair of the board of Resources for Ecumenical Spirituality.     

INCREASING CALORIE CONSUMPTION IN CHILDREN WITH CYSTIC FIBROSIS: REPLICATION WITH 2-YEAR FOLLOW-UP

Three mildly malnourished children with cystic fibrosis and their parents participated in a behavioral group-treatment program that focused on promoting and maintaining increased calorie consumption. Treatment included nutritional education, gradually increasing calorie goals, contingency management, and relaxation training, and was evaluated in a multiple baseline design across four meals. Children's calorie intake increased across meals, and total calorie intake was 32% to 60% above baseline at posttreatment. Increased calorie consumption was maintained at the 96-week follow-up (2 years posttreatment). The children's growth rates in weight and height were greater during the 2 years following treatment than the year prior to treatment. Increases in pace of eating and calories consumed per minute were also observed 1 year posttreatment. These findings replicated and extended earlier research supporting the efficacy of behavioral intervention in the treatment of malnutrition in children with cystic fibrosis.     

Contributors to the Appraisal of Major Life Changes: Gender, Perceived Controllability, Sensation Seeking, Strain, and Social Support

This study investigated relationships between the appraisal of life events and gender, locus of control, social support, strain, and sensation seeking. In group sessions, undergraduate males and females completed self-report measures assessing life events appraisals and self-report measures for the above individual differences. Analyses supported the notion that a range of these variables, previously shown to serve as moderators of life stress, are significantly related to the appraisals of life events. Moreover, in addition to the gender differences obtained for the perception of life events, gender was found to influence several associations between the individual differences and life events appraisal.     

Athletic self-concept and mathematics achievement in girls

Several researchers have suggested that girls' mathematics performance may be mediated by an assertive sex role or "masculine interest." The present study made the assumption that girls' athletic self-confidence reflects "masculine interest" so girls' test scores for perceived athletic competence would be related to their mathematics achievement scores. A total of 207 boys and girls in Grades 4, 5, and 6 were tested for their perceived athletic ability using the Athletic Competence subscale of Harter's 1985 Self-perception Profile, and these scores were correlated with their mathematics achievement as measured on the Metropolitan Achievement Test and term grades. A low but significant correlation with Athletic Competence scores was found for girls on both measures of mathematics achievement. Although boys scored higher on the Athletic Competence subscale, there were no sex differences on either measure of mathematics achievement. Results are discussed in terms of both sex-role theory and cognitive development.     

Conversational time patterns and mutual influence in parent-child interactions: A time series approach

Mutual influencing processes are assumed to be the basic building blocks in establishing parentchild bonding and in influencing cognitive and language behavior. A study by Jasnow and Feldstein (1986) revealed that, within the temporal domain of speech, preverbal (9-month-old) infants and their mothers exhibit a pattern of mutual influence (attunement) in their average durations of switching pauses. The general purpose of this research was to extend those findings to children with higher verbal functioning. In addition, parent and child genders, nature of the interaction, and specific aspects of parents' personalities, expressiveness, and instrumentality were considered. Each parent interacted with their 4-or 5-year-old son or daughter in each of two conversations—unstructured (social conversation) and structured (task activity). Conversations were processed by an automated computer system yielding objective measure of turns, vocalizations, pauses, and switching-pause durations. To examine interspeaker influence or attunement of temporal speech patterns, influence coefficients were computer for each speaker on a turn-by-turn basis using time series regression. Analysis of these coefficients revealed that: (1) Mutual influence is most evident with switching-pause duration. (2) Structure in the conversation (as defined by the task or parental instrumentality) seems to facilitate attunement for vocalization and switching pause duration. (3) Attunement with girls seems to occur equally well with both parents, while boys exhibit a style of temporal patterning influence which suggests greater identification with the father. (4) Expressiveness seems to facilitate attunement to the child's switching-pause duration.     

On differentiating embarrassment from shame

Four experiments were conducted to demonstrate that embarrassment and shame are distinct emotions that result from violations of different types of internalized standards. Embarrassment results from violating one's particular persona; shame results from violating a shared, objective ideal. Subjects vividly imagined themselves in situations and indicated their emotional reactions. In Experiment I, we demonstrate that people differentiate between embarrassment and shame systematically (F(1,27) = 74.4, p < 0.001). In Experiments 2 and 3, we demonstrate that embarrassment results from violating a persona (n = 34, p < 0.001; n = 23, p < 0.001), and shame results from violating an objective ideal (n = 34, p < 0.001; n = 23, p < 0.001). In Experiment 4, we demonstrate that it is the type of standard that is violated (n = 30, p < 0.001), not whether or not the violation was intentional, that determines whether one experiences embarrassment or shame. We argue that both shame and embarrassment play an important role in maintaining personal identity.     

The analysis of one-way between effects in fluency research

In fluency research, the potential for extreme variance heterogeneity exists when comparing stutterers to other disordered or control populations. There is now a growing concern on the part of statisticians that the F statistic is not nearly so robust to violations of the homogeneity of variance assumption as was once thought. Together, these two circumstances represent potential for compromise on the statistical conclusion validity of fluency research. In this first of two papers, alternatives to the usual analysis of variance are described for the research design involving a single between effect. A second paper will be a similar treatment of the two-way between effects design.