Patterns of neural response to emotive stimuli distinguish the different symptom dimensions of obsessive-compulsive disorder

Despite its heterogeneous symptomatology, obsessive-compulsive disorder (OCD) is currently conceptualized as a unitary diagnostic entity. Recent factor-analytic studies have identified several OCD symptom dimensions that are associated with different demographic variables, comorbidity, patterns of genetic transmission, and treatment response. Functional abnormalities in neural systems important for emotion perception, including the orbitofrontal cortex, lateral prefrontal cortex, anterior cingulate gyrus, and limbic regions, have been reported in OCD. In this review, we discuss the extent to which neurobiological markers may distinguish these different symptom dimensions and whether specific symptom dimensions, such as contamination/washing, are associated with abnormalities in emotion and, in particular, disgust, perception in OCD. Also discussed are findings that indicate that anxiety can be induced in healthy volunteers in response to OCD symptom-related material, and that associated increases in activity within neural systems important for emotion perception occur to washing- and hoarding-related material in particular in these subjects. Further examination of neural responses during provocation of different symptom dimensions in OCD patients will help determine the extent to which specific abnormalities in neural systems underlying emotion perception are associated with different symptom dimensions and predict treatment response in OCD.     

The role of structural prediction in rapid syntactic analysis

A number of recent electrophysiological studies of sentence processing have shown that a subclass of syntactic violations elicits very rapid ERP responses, occurring within around 200 ms of the onset of the violation. Such findings raise the question of how it is possible to diagnose violations so quickly. This paper suggests that very rapid diagnosis of errors is possible specifically in situations where the diagnosis problem is tightly constrained by specific expectations generated before the critical word is presented. In an event-related potentials (ERP) study of visual sentence reading participants encountered violations of a word order constraint (...Max's of...) that has elicited early ERP responses in previous studies. Across conditions the illicit sequence was held constant, while sentence context was used to manipulate the expectation for a noun following the possessor Max's, by manipulating the possibility of ellipsis of the head noun. Results showed that the anterior negativity elicited by the word category violation was attenuated when the availability of ellipsis reduced the expectation for a noun in the position of the offending preposition of, with divergence between conditions starting around 200 ms after the onset of the violation. This suggests a role for structural expectations in accounting for very fast syntactic diagnosis processes.     

Family secrecy: a comparative study of juvenile sex offenders and youth with conduct disorders

The reported research was designed to compare adjudicated male juvenile sexual offenders and youth with conduct disorders on five aspects of family secrecy and deception. Twenty-nine male juvenile sex offenders and 32 comparison youth from three child welfare agencies in New York State participated in the study. Research assistants, blind to the hypotheses of the study and status of the youth, coded agency records for five variables identified a priori as a basis of comparison. Analyses revealed that the two groups were different on three of the five and on the total number of items scored. Families of juvenile sex offenders told more lies, had more family myths, and were more likely to be involved in taboo behavior. Logistic regression revealed that this factor of family deception significantly increased the odds of sexual offending over and above other measures of family pathology. These data support the hypotheses of the study and have implications for both clinical practice and future research in this area.     

Depersonalization disorder: a functional neuroanatomical perspective

Clinical reports of depersonalization suggest that attenuated emotional experience is a central feature of the condition. Patients typically complain of emotional numbness and some patients ascribe their feelings of unreality to a lack of affective "colouring" in things perceived. Recent neuroimaging and psychophysiological studies support these assumptions as they show both attenuated autonomic responses in depersonalization, and decreased activity within neural regions important for the generation of affective responses to emotive stimuli. Furthermore, findings from neuroimaging studies indicate increased prefrontal cortical activity in depersonalised patients, particularly within regions associated with contextualization and appraisal of emotionally-salient information rather than mood induction per se. Taken together, these finding suggest that symptoms of depersonalization, and in particular emotional numbing, may be related to a reversal of normal patterns of autonomic and neural response to emotive stimuli.     

Effects of involuntary outpatient commitment on subjective quality of life in persons with severe mental illness

Recent evidence suggests that involuntary outpatient commitment (OPC), when appropriately applied, can improve adherence with psychiatric treatment, decrease hospital recidivism and arrests, and lower the risk of violent behavior in persons with severe mental illness. Presumably these are benefits that improve quality of life (QOL); however, insofar as OPC involves legal coercion, the undesirable aspects of OPC could also exert a negative effect on quality of life, thus offsetting clinical benefits. Involuntarily hospitalized subjects, awaiting discharge under outpatient commitment, were randomly assigned to be released or continue under outpatient commitment in the community after hospital discharge, and were followed for one year. Quality of life was measured at baseline and 12 months follow-up. Treatment characteristics and clinical outcomes were also measured.Subjects who underwent longer periods of outpatient commitment had significantly greater quality of life as measured at the end of the 1 year study. Multivariable analysis showed that the effect of OPC on QOL was mediated by greater treatment adherence and lower symptom scores. However, perceived coercion moderated the effect of OPC on QOL. Involuntary outpatient commitment, when sustained over time, indirectly exerts a positive effect on subjective quality of life for persons with SMI, at least in part by improving treatment adherence and lowering symptomatology.     

Conflicting directional and locational cues afforded by arrowhead cursors in graphical user interfaces

Task-irrelevant features of arowhead cursors may generate conflict during cursor placement within graphical user interfaces. Arrowheads can signify location, but also cue direction and feature in optical illusions. To address the influence of conflicting cues, 14 participants used arrowhead cursors (standard, oversized) pointing upward or downward to move to targets (7.5, 15-mm diameter) situated at the top or bottom of the screen. Compatible arrowhead orientation improved response initiation. Cursor size, orientation, direction of motion, and target size interacted during cursor movement. Overshooting occurred for oversized cursors in the direction the arrow pointed for larger targets. Larger compatible arrowhead cursors elicit less efficient cursor positioning movements that are more susceptible to illusory processes, posing implications for design of cursors and graphical user interfaces.     

The Poggendorff illusion: premeditated or unpremeditated misbehaviour?

Poggendorff illusions have sometimes been explained as arising in a two-stage process, with misalignment consequent upon prior, independently observable misjudgments of angle, extent, or proportion. However, several misalignments combined in one figure can be arranged so that if such prior illusions were the cause, they would have to transform simultaneously in opposed directions to save appearances. When Poggendorff misalignments are deliberately embedded in other illusions, results are intriguingly various, but the comparison of Poggendorff figures with and without associated illusions suggests that the underlying misalignments arise from pre-attentive cues, local to each traverse across a gap.     

Covariates of production and perseveration on tests of phonemic, semantic and alternating fluency in normal aging

Standard measures of phonemic and semantic fluency, as well as fluency measures that impose additional demands upon set-switching were administered to younger and older adults. No age effect was found for total output on semantic fluency, while older participants generated significantly more responses relative to their younger counterparts on the phonemic measure. However, older adults made significantly more perseverative errors on both these measures. For tests of alternating fluency, only where participants were required to switch between two semantic dimensions, was an age deficit observed. Although the correlation between phonemic repetitions and age remained significant when performance on the Digit Symbol Test or a measure of fluid intelligence was partialled out, age effects for semantic repetitions and semantic alternating fluency were substantially reduced. The age benefit for number of correct responses upon phonemic fluency was significantly attenuated when a measure of crystallized intelligence was entered as a control variable. The theoretical and practical implications of these results are discussed.     

The relation between auditory temporal interval processing and sequential stream segregation examined with stimulus laterality differences

In this study, we examine the effects of laterality differences between noise bursts on two objective measures of temporal interval processing (gap detection and temporal asymmetry detection) and one subjective measure of temporal organization (stream segregation). Noise bursts were lateralized by presentation to different ears or dichotic presentation with oppositely signed interaural level (ILD) or time (ITD) differences. Objective thresholds were strongly affected by ear-of-entry differences, were moderately affected by ILD differences, but were unaffected by ITD differences. Subjectively, A and B streams segregated well on the basis of ear-of-entry or ILD differences but segregated poorly on the basis of ITD differences. These results suggest that perceptual segregation may be driven more effectively by differential activation of the two ears (peripheral channeling) than by differences in perceived laterality.