The Commercialization of Clinical Genetics: An Analysis of Interrelations Between Academic Centers and For-Profit Clinical Genetics Diagnostics Companies

The field of clinical genetics has undergone substantial commercialization, including the development of genetics diagnostics companies. Numerous for-profit corporations now offer genetic diagnostic services; until recently, these clinical services were provided almost exclusively through academic, not-for-profit medical centers. Some of these for-profit corporations have business and/or research relationships with academia. An evaluation of the interconnections between academia and the clinical genetics industry is an important first step in analyzing the risks and benefits of commercialization. We analyzed the personnel and business affiliations of 19 major U.S. for-profit clinical genetics diagnostics companies with universities, academic medical centers, and the scientific and medical genetics communities in a 2-year period, 1991–1992. We noted extensive connections between the for-profit sector and academia. At least 17% of high-ranking personnel and 85% of consultants for the companies had one or more academic ties. At least 68% of the companies had one or more business agreements with at least one university or academic medical center. These results raise many issues regarding the delivery of genetic medicine and the structure and function of academic medical genetics centers.     

Temporal binding errors are redistributed by the attentional blink

When one searches for a target among nontargets appearing in rapid serial visual presentation (RSVP), one’s errors in performance typically involve the misreporting of neighboring nontargets. Such illusory conjunctions or intrusion errors are distributed differently around the target, depending on task or stimulus variables. It is shown here that shifts in intrusion error patterns can be produced by the manipulation of attention alone. In a dual-task paradigm, the magnitude and distribution of intrusion errors changed systematically as a function of available attentional resources. Intrusion errors in RSVP tasks reflect internal capacity limitations for binding independent features. The present results support a two-stage model of RSVP target processing.     

Psychotherapists and the clergy: Fifty years later

Jung's two powerful articles on psychotherapy and the clergy, written in 1928 and 1932. are looked at from the vantage point of fifty years later and the author's experience in conducting analysis with many people from both vocations. He notes that relatively few people achieve the kind of integration of the ego that Jung writes about-an essentially religious experience-wherein the center of their existence now gravitates about the Self. Yet Jung's work and views have had a profound effect on spiritually inclined people of all ages. The predictions of Jung's articles, regarding therapy, the dissemination of pyschology to the masses, and other issues are examined.     

Characteristics of changes of personal odor after experimental bone marrow transplantation]

In an operant conditioning paradigm 4 Balb/c inbred strain mice were conditioned to discriminate between urine samples of two other inbred strains. The purpose was to examine whether or not the known stimulus configuration during training had any effect upon the rate of recognition of other stimuli. On the basis of this procedure, we subsequently investigated the extent to which an allogeneic bone marrow transplantation interferes with the olfactory identity of an individual. For the transplants a strain was inbred which had no contact to the animals tested, a procedure used for the first time here. Furthermore, also for the first time, it was possible to demonstrate in a direct comparison, the role played by donor versus recipient characteristics on the olfactory composition of the recipients odor.     

Cognitive and projective measures of differentiation and their relationship to empathy

The present investigation compared cognitive and projective methods of assessing “differentiation,” Witkin's Embedded Figures Test (EFT) and Blatt's Concept of the Object Scale (COS), and reexamined expectations concerning the relationship between level of differentiation and capacity for empathy. Whether lesser or greater differentiation would promote empathy was of specific interest. Two forms of empathy were investigated, an “affective” form assessed by the Mehrabian Empathy Scale and a “cognitive” form assessed by the Hogan Empathy Scale. Expected sex differences in differentiation and empathy were also investigated. Results demonstrated consonance between COS and EFT measures of differentiation within the male sample only (p < .05). Individuals classified by EFT as relatively less differentiated (“field dependent”) produced more part object responses (p < .02) and those classified as more differentiated (“field independent”) showed a trend toward more whole object responses (p < .10) on the COS. Associations between measures of differentiation and empathy reached significance or showed trends in the male group only. Men with relatively lesser differentiation on the EFT (“field dependent”) showed greater “affective empathy” (p < .10) and men with greater differentiation on the COS showed greater “cognitive” empathy (p < .05). Women demonstrated higher levels of “affective” empathy than men (p < .001).     

Predictive validation of an insurance agent support person selection battery

This study investigated the predictive validity of a selection battery for insurance agent support persons. The selection battery included cognitive tests, personality scales, and biodata scales. Predictor data were collected as part of the agent support person selection process. Behavior summary scale ratings made by immediate supervisors of agent support persons were used as criteria in this study. Uncorrected correlations for six matched predictor composite-criterion dimension combinations identified in a previous concurrent validation study (Ashworth, Barge, Dunnette, & Carter, 1987) ranged from .17 (p<. 01) to .28 (p< .01) (M=.21, N=357).     

The family as portrayed on prime-time television, 1947–1990: Structure and characteristics

Successful family series across four decades of American prime-time television were examined. Family portrayals were defined as either conventional or nonconventional. Conventional families were categorized as couples without children and couples with children. Nonconventional families were categorized as single parent or contrived. Additional family characteristics were also recorded including sex of single parent, reason for singleness, social class status, females employed outside the home, live-ins, race, and whether the presentation was dramatic or comedic. The data show a trend toward more equal presentation of conventional and nonconventional families, few divorced or female single parents, and few minority families. Implications of findings are discussed and future research questions suggested.     

Spatial problem solving: The integration of independently learned cognitive maps

The process of mentally integrating separate regions of a layout into a unified representation is a critical component in generating inferred spatial information. Blindfolded subjects learned two different paths by tactual exploration. The subjects were then given information that permitted them to integrate the two cognitive maps of the paths into one map. In Experiment I, the speed and accuracy of originally learned and inferred movements within a path were equivalent, whereas inferred movements between the two paths were significantly slower and less accurate. In Experiment 2, the subjects could request additional training on the paths before they were given the integration information, and they also rated how well they knew the path on which they were tested. When the subjects judged that they remembered all or most of the path information, movements between two paths and within one path were performed with the same accuracy. The equivalent accuracy of all the movements suggests that cognitive integration can generate an accurate representation of an integrated layout when the path information is recalled.