A four-part working bibliography of neuroethics: part 1: overview and reviews – defining and describing the field and its practices

Background

Neuroethics entails investigations of neurocognitive mechanisms of morality and ethics; and studies and address of the ethical issues spawned by the use of neuroscience and its technologies to investigate cognition, emotion and actions. These two principal emphases, or what have been called “traditions” of neuroethics both mirror traditional bioethical discussions (such as debates about the safety of technological and pharmaceutical advances and ethical implications of new scientific and technological discoveries), and engage discourse about neuroscientific investigations of (proto-moral and moral) cognition, emotions and behaviors, and what such findings may mean for human beliefs and conduct - from the individual to the political levels.Given the growth, range, and rapid maturation of the field of neuroethics we provide an iterative, four-part document that affords a repository of international papers, books, and chapters that address the field in overview, and present discussion(s) of more particular aspects and topics of neuroethics. This first installment lists reviews and overviews of the discipline, and broad summaries of basic developments and issues of the field.

Methods

To systematically survey the neuroethics literature, searches were performed by accessing 11 databases, 8 additional literature depositories, and 4 individual journal searches using indexing language for National Library of Medicine (NLM) Medical Subject Heading databases. Searches and assurance against overlapping coverage were conducted using the RefWorks citation management program.

Results

Overview, review and reflections upon the history and multicultural perspectives of neuroethics were obtained and relevant listings from international journals, books, and book chapters are provided. Part I will be followed by three installments that will address a): the neuroscience of morality and ethics, including discussions of free will, and personal autonomy; b) “second tradition neuroethics”, to include specific ethical issues in neuroscience; clinical neuroethics; and c) neuroethics education/training; neuroethics and society; neuroethics and law; neuroethics and policy; and international neuroethics.

     

Using scissors to bisect a line: A perception–action dissociation in complex tool use

Previous research has shown that unilateral visual neglect is improved when patients are required to actively grasp an object at its center, rather than only pointing to its center. A similar dissociation between pointing and grasping responses has been reported for pseudoneglect, a spatial bias toward the left side of space that is normally exhibited by healthy participants. Among other theories, the two-visual-streams hypothesis has been offered as an explanation for these dissociations. According to this hypothesis, highly practiced actions that are performed under easily available visual input (e.g., grasping an object) are controlled by the dorsal stream and can resist perceptual judgment biases. We investigated whether, in pseudoneglect, dissociations between perceptual judgments and motor–manipulative responses occur when participants have to respond with complex tools that are highly practiced but that have been shown to rely on both ventral- and dorsal-stream processing. In a standard line bisection task, participants had to either mark the center of a line with a pencil or cut the line in two halves using a pair of scissors. The results indicated the typical leftward bias (pseudoneglect) in the pencil task, whereas performance was much more accurate in the scissors task. These results show that actions featuring complex tool use can resist perceptual judgment biases, and the findings are discussed with reference to existing accounts of perception–action dissociations.     

Perception of Temporal Order: The Effects of Age,Sex, and Cognitive Factors

ABSTRACT

The present paper investigates the effects of age, sex, and cognitive factors on temporal-order perception. Nine temporal-order tasks were employed using two and four stimuli presented in the auditory and visual modalities. Significantly increased temporal-order thresholds (TOT) in the elderly were found for almost all tasks, while sex differences were only observed for two tasks. Multiple regression analyses show that the performance on most temporal-order tasks can be predicted by cognitive factors, such as speed of fluid reasoning, short-term memory, and attention. However, age was a significant predictor of TOT in three tasks using visual stimuli. We conclude (1) that age-related differences can often be attributed to cognitive factors involved in temporal-order perception, and (2) that the concept of temporal-order perception is more complex than implied by the current models.     

Positivity effect in healthy aging in observational but not active feedback-learning

ABSTRACT

The present study investigated the impact of healthy aging on the bias to learn from positive or negative performance feedback in observational and active feedback learning. In active learning, a previous study had already shown a negative learning bias in healthy seniors older than 75 years, while no bias was found for younger seniors. However, healthy aging is accompanied by a ‘positivity effect’, a tendency to primarily attend to stimuli with positive valence. Based on recent findings of dissociable neural mechanisms in active and observational feedback learning, the positivity effect was hypothesized to influence older participants' observational feedback learning in particular. In two separate experiments, groups of young (mean age 27) and older participants (mean age 60 years) completed an observational or active learning task designed to differentially assess positive and negative learning. Older but not younger observational learners showed a significant bias to learn better from positive than negative feedback. In accordance with previous findings, no bias was found for active learning. This pattern of results is discussed in terms of differences in the neural underpinnings of active and observational learning from performance feedback.     

Psychological Well-Being and Resilience as Predictors of First-Year Students' Academic Performance

This study investigated aspects of psychological well-being (burnout and engagement) and resilience as predictors of the academic performance of a group of first-year students at a higher education institution. Participants included 789 first-year students at a South African university (females = 43%, majority ethnicity Black African = 58%). They completed measures of burnout, engagement and resilience. Data were analysed using stepwise multiple regression to determine whether burnout, engagement and resilience were statistically significant predictors of first year students' academic performance. The results indicated that burnout (specifically Emotional Exhaustion and Cynicism) and resilience (specifically Religion) were statistically significant predictors of academic performance. Students with lower levels of cynicism, who are emotionally and cognitively more involved in their studies, seem to perform better. Surprisingly, students who reported being emotionally more exhausted performed well in their studies. Those students who seem to have strong spiritual/religious beliefs also fared better with regard to academic performance than those of lower religious faith. Strong spiritual/religious anchors and continuous cognitive and emotional involvement in academic work are valuable resources to students in their academic performance.     

To be or not to be at risk: Spontaneous reactions to risk information

Rheumatoid arthritis (RA) is a chronic disease, which can lead to considerable psychological distress. The present study evaluated anxiety and depression symptoms for this chronic and painful illness within the framework of the conservation of resources (COR) theory. Coping strategies, coping self-efficacy, religiousness and social support are very important personal resources, which have been found to protect individuals from psychological distress. The aim of the present study was to examine the predictive values of socio-demographic and illness-related variables, perceived social support, ways of coping, religiousness, arthritis self-efficacy and resource loss for psychological distress in a sample of 117 RA patients from Turkey, a secular, Islamic, non-western developing country. The results revealed that RA patients experience considerable anxiety and depressive symptoms. The results of the regression analysis showed that gender, helplessness coping and resource loss are significant predictors of anxiety, whereas arthritis self-efficacy and resource loss are significant predictors of depression. Resource loss appeared as an important predictor for both anxiety and depression. This finding was consistent with the COR theory. The clinical implications of these findings are discussed.     

The role of risk perception and efficacy cognitions in the prediction of HIV-related preventive behavior and condom use

Abstract

Based on empirical findings on the central model variables of the Protection Motivation Theory, the influence of perceived susceptibility, perceived severity of the threat of AIDS, communicative and sexual self-efficacy, and outcome expectancy on various aspects of HIV-preventive behavior was examined. The study was based on a sample of 468 heterosexual adults between the ages of 20 and 45 years. The data were obtained by means of questionnaires filled out at various vacation sites that draw mass tourism or in the subjects' home town. The most significant predictor of behavior was found to be self-efficacy expectancy as regards assertiveness and use of HIV-related preventive measures. A high communicative self-efficacy expectancy, on the other hand, is associated with a higher level of risk behavior among certain subgroups and under certain behavioral aspects. This confirms the necessity of acknowledging the different forms of self-efficacy expectancy in sexual interactions. Perceived personal threat is also associated with risk behavior with respect to certain behavioral operationalizations. From this it can be concluded that one's own behavior is used as the basis for appraising one's susceptibility. The results also show that distinctions must be made when analyzing HIV-related risk behavior. In particular, a difference must be made between absolute behavior (degree of the risk behavior) and relative behavior (change - especially reduction - in risk behavior due to the danger of AIDS).     

Dissociation of facial attractiveness and distinctiveness processing in congenital prosopagnosia

According to the influential model of Bruce and Young (1986) socially relevant facial information is processed separately from facial information leading to individual face recognition. In recent years functional imaging has identified a network of distinct occipitotemporal cortex areas for the processing of these two kinds of information. Functionally it is not clear at which processing level the “social” and the “recognition” pathways diverge. The study of subjects with a profound face recognition and learning deficit (congenital prosopagnosia—cPA) promises for a better understanding of this issue. We therefore tested the perception of attractiveness (a cue of prime social importance) and distinctiveness (a facial feature related to recognition) in 14 people with cPA. Although attractiveness ratings were highly consistent with controls, cPA subjects' distinctiveness ratings showed random patterns. This dissociation of normal attractiveness processing and impaired distinctiveness processing in cPA helps to specifies the nature of the impairment in this condition while shedding light on the functional architecture of normal face processing.