A four-part working bibliography of neuroethics: Part 4 - Ethical issues in clinical and social applications of neuroscience

Background

As a discipline, neuroethics addresses a range of questions and issues generated by basic neuroscientific research (inclusive of studies of putative neurobiological processes involved in moral and ethical cognition and behavior), and its use and meanings in the clinical and social spheres. Here, we present Part 4 of a four-part bibliography of the neuroethics literature focusing on clinical and social applications of neuroscience, to include: the treatment-enhancement discourse; issues arising in neurology, psychiatry, and pain care; neuroethics education and training; neuroethics and the law; neuroethics and policy and political issues; international neuroethics; and discourses addressing "trans-" and "post-" humanity.

Methods

To complete a systematic survey of the literature, 19 databases and 4 individual open-access journals were employed. Searches were conducted using the indexing language of the U.S. National Library of Medicine (NLM). A Python code was used to eliminate duplications in the final bibliography.

Results

When taken with Parts 1-3, this bibliography aims to provide a listing of international peerreviewed papers, books, and book chapters published from 2002 through 2016. While seeking to be as comprehensive as possible, it may be that some works were inadvertently and unintentionally not included. We therefore invite commentary from the field to afford completeness and contribute to this bibliography as a participatory work-in-progress.

     

Philosophical research on cognition

At the turn of the twentieth century, a number of philosophers introduced the idea of philosophical research on cognition that could enter into competition with psychology, which was developing into an autonomous discipline at that time. In view of the problems of the traditional but still prevailing associationist theory, Ernst Cassirer demanded a more sophisticated theory that could explain the human ability to concentrate one’s thoughts on a topic, such as a problem or a task. He presented a representational theory of mind to explain this ability. This paper explicates the scope of this theory and Cassirer’s idea of interdisciplinary cooperation between philosophers and psychologists.     

EEG correlates of postural audio-biofeedback

The control of postural sway depends on the dynamic integration of multi-sensory information in the central nervous system. Augmentation of sensory information, such as during auditory biofeedback (ABF) of the trunk acceleration, has been shown to improve postural control. By means of quantitative electroencephalography (EEG), we examined the basic processes in the brain that are involved in the perception and cognition of auditory signals used for ABF. ABF and Fake ABF (FAKE) auditory stimulations were delivered to 10 healthy naive participants during quiet standing postural tasks, with eyes-open and closed. Trunk acceleration and 19-channels EEG were recorded at the same time. Advanced, state-of-the-art EEG analysis and modeling methods were employed to assess the possibly differential, functional activation, and localization of EEG spectral features (power in α, β, and γ bands) between the FAKE and the ABF conditions, for both the eyes-open and the eyes-closed tasks. Participants gained advantage by ABF in reducing their postural sway, as measured by a reduction of the root mean square of trunk acceleration during the ABF compared to the FAKE condition. Population-wise localization analysis performed on the comparison FAKE - ABF revealed: (i) a significant decrease of α power in the right inferior parietal cortex for the eyes-open task; (ii) a significant increase of γ power in left temporo-parietal areas for the eyes-closed task; (iii) a significant increase of γ power in the left temporo-occipital areas in the eyes-open task. EEG outcomes supported the idea that ABF for postural control heavily modulates (increases) the cortical activation in healthy participants. The sites showing the higher ABF-related modulation are among the known cortical areas associated with multi-sensory, perceptual integration, and sensorimotor integration, showing a differential activation between the eyes-open and eyes-closed conditions.     

Girls’ Stuff,boys’ stuff and mental rotation: fourth graders rotate faster with gender-congruent stimuli

Males outperform females in mental-rotation for various reasons, e.g. stimuli characteristics. This study tested the hypothesis that girls and boys solve mental-rotation tests with female- or respectively male-stereotyped objects faster and more correctly. 116 fourth-graders solved a chronometric mental-rotation test with either female- or male-stereotyped action-based objects as stimulus material and reported their solution strategies and familiarity with handling the objects in real life. Boys reacted faster than girls only in the male-stimuli condition, while gender differences were inversed in the female-stimuli condition. All children were faster with gender-congruent material, probably provoked by gender-schematic processing or stereotype lift effects. Furthermore, analytic solving strategies appeared as efficient as holistic strategies in gender-congruent conditions, while holistic strategies were more advantageous only in gender-incongruent conditions. The congruence of stimulus material and gender best predicted children’s reaction time. Practical implications are considered regarding the importance of diverse and gender-equalised material to assess mental-rotation skills.     

Psycholinguistic evidence for the underspecification of morphosyntactic features

This paper investigates the paradigmatic relations between inflected word forms (or their affixes) and the feature specifications of these elements. In two sentence-matching experiments German speakers had to decide whether sentence pairs involving inflected adjectives or determiners were identical or not. In both experiments, there was a delay when an inflected form contained positive feature specifications for grammatical features that did not match the feature specifications of the grammatical context in which it appeared. No delay, however, occurred when an incorrectly inflected form had mismatching negative specifications, whereas its positively specified features matched the respective positive features of the context. This result provides evidence for a different status of positively and negatively specified morphosyntactic features. It supports the idea of radical underspecification according to which only positive feature specifications are part of the representations of morphologically complex forms or affixes, whereas negative feature specifications are assigned on the basis of paradigmatic contrasts.     

Early maladaptive schemas in personality disordered individuals

The present study aimed to examine the specificity of schema domains in three personality disorder (PD) groups, namely borderline (BPD), obsessive-compulsive (OCPD), and avoidant PD (AvPD), and to correctly identify the three PD groups on the basis of these schemas. The sample consisted of 48 clinical participants diagnosed with PDs and assigned to 1 of 3 groups on the basis of their Axis II diagnoses (BPD: n = 13; OCPD: n = 13; AvPD: n = 22). High scores on Dependence/Incompetence, Defectiveness/ Shame and Abandonment were found for the BPD group. Such pattern appears to be most consistent with Young's theory of BPD. Consistent with the theory and empirical findings of Beck et al. (1990, 2001), OCPD was associated with elevations on the Unrelenting Standards schema domain, but not on Emotional Inhibition, which was found to be elevated for AvPD. In conclusion, the present study suggests that there are different patterns of schema domains across different PDs and that the Schema Questionnaire (SQ) is potentially useful in differentiating between these PDs.     

Word order in sentence processing: an experimental study of verb placement in German

We examine the question of whether the human comprehension device exhibits word-order preferences during on-line sentence comprehension. The focus is on the positioning of finite verbs and auxiliaries relative to subjects and objects in German. Results from three experiments (using self-paced reading and event-related brain potentials) show that native speakers of German prefer to process finite verbs in second position (i.e., immediately after the subject and before the object). We will account for this order preference in terms of the relative processing costs associated with SV_fO and SOV_f. Our finding that word-order preferences play an important role in the on-line comprehension of German sentences is compatible with results from previous studies on English and other languages.     

The processing of rhythmic structures in music and prosody by children with developmental dyslexia and developmental language disorder

Rhythm perception seems to be crucial to language development. Many studies have shown that children with developmental dyslexia and developmental language disorder have difficulties in processing rhythmic structures. In this study, we investigated the relationships between prosody and musical processing in Italian children with typical and atypical development. The tasks aimed to reproduce linguistic prosodic structures through musical sequences, offering a direct comparison between the two domains without violating the specificities of each one. About 16 Typically Developing children, 16 children with a diagnosis of Developmental Dyslexia, and 16 with a diagnosis of developmental language disorder (age 10–13 years) participated in the experimental study. Three tasks were administered: an association task between a sentence and its humming version, a stress discrimination task (between couples of sounds reproducing the intonation of Italian trisyllabic words), and an association task between trisyllabic nonwords with different stress position and three‐notes musical sequences with different musical stress. Children with developmental language disorder perform significantly lower than Typically Developing children on the humming test. By contrast, children with developmental dyslexia are significantly slower than TD in associating nonwords with musical sequences. Accuracy and speed in the experimental tests correlate with metaphonological, language, and word reading scores. Theoretical and clinical implications are discussed within a multidimensional model of neurodevelopmental disorders including prosodic and rhythmic skills at word and sentence level.     

Measurement invariance of the Phubbing Scale across 20 countries

Mobile phone addiction is a robust phenomenon observed throughout the world. The social aspect of mobile phone use is crucial; therefore, phubbing is a part of the mobile phone addiction phenomenon. Phubbing is defined as ignoring an interlocutor by glancing at one's mobile phone during a face-to-face conversation. The main aim of this study was to investigate how the Phubbing Scale (containing 10 items) might vary across countries, and between genders. Data were collected in 20 countries: Belarus, Brazil, China, Croatia, Ecuador, India, Israel, Italy, Netherlands, Pakistan, Poland, Portugal, Serbia, Slovakia, Slovenia, Spain, Turkey, UK, Ukraine and USA. The mean age across the sample (N = 7696, 65.8% women, 34.2% men) was 25.32 years (SD = 9.50). The cross-cultural invariance of the scale was investigated using multigroup confirmatory factor analyses (MGCFA) as well as the invariance analyses. Additionally, data from each country were assessed individually via confirmatory factor analyses (CFAs). We obtained two factors, based on only eight of the items: (a) communication disturbances and (b) phone obsession. The 8 items Phubbing Scale.