The paradox of quetiapine in obsessive-compulsive disorder

Schizophrenia and obsessive-compulsive disorder (OCD) have historical, clinical, and epidemiological links. The clinical use of atypical neuroleptics (ie, dual serotonin-dopamine antagonists) to treat both conditions sheds a new light on them. We report the first two cases of obsessive-compulsive symptoms (OCS) induced by quetiapine in schizophrenia patients. A case of successful augmentation by quetiapine in refractory OCD is also presented. A review of the literature on OCS induced by atypical neuroleptics follows. This paradoxically induced OCD symptomology in schizophrenia patients administered atypical neuroleptics is discussed from new pathophysiological and clinical perspectives. The discussion emphasizes the prognostic implications of OCS in schizophrenia and available therapies for this comorbidity.     

Communication strategies to promote spiritual well-being among people with dementia

Declining communication skills in dementia threaten a person's sense of self. Building on enduring capabilities, pastoral visitors can significantly enhance spiritual well-being through the use of individualized, person-centered strategies. This article outlines the primary spiritual needs of older adults with dementia and some general strategies to improve communication based on enduring abilities. Detailed examples illustrate how these personhood-centered strategies can meet spiritual needs by connecting with individuals with dementia through life stories and through helping them to participate in religious life.     

Female physical attractiveness in Britain and Malaysia: a cross-cultural study

Two purported cues to perceived female physical attractiveness are body mass index (BMI) and body shape as measured by the waist-to-hip ratio (WHR). This study examined the relative contribution of both cues in several culturally socio-economically distinct populations. Six hundred and eighty-two participants from Britain and Malaysia were asked to rate a set of images of real women with known BMI and WHR. The results showed that BMI is the primary determinant of female physical attractiveness, whereas WHR failed to emerge as a significant predictor. The results also showed that there were significant differences in preferences for physical attractiveness along a gradient of socio-economic development, with urban participants preferring images of women with significantly lower BMIs than their rural counterparts. The findings are discussed in terms of evolutionary psychological explanations of mate selection, and sociocultural theory, which emphasises the learning of preferences for body sizes in social and cultural contexts.     

AJCP as a Vehicle for Improving Community Life: An Historic–Analytic Review of the Journal’s Contents

The current article is an analysis of the research represented in American Journal of Community Psychology (AJCP) from 1993 to 1998, including a comparison to two previously published analytic reviews by Lounsbury et al. (J. W. Lounsbury, D. S. Leader, E. P. Meares, & M. P. Cook, 1980) and Speer et al. (P. Speer, A. Dey, P. Griggs, C. Gibson, B. Lubin, & J. Hughey, 1992), respectively. Observed trends are examined with references to major epistemological frameworks and methods used to define community psychology. Four guiding principles were examined to determine the representation of the epistemological frameworks of the articles published in the journal. The frameworks include social action, human diversity and cultural relativity, person–environmental fit, and methodological procedures. The results document the transition of community psychology from its early beginnings to an independent field conducting research consistent with the values articulated at the Swampscott Conference. This paper also comments on how well, after three decades of publication, the journal has served as a vehicle for improving community life.     

Effects of 3-D complexity on the perception of 2-D depictions of objects

In a recent study, Pelli (1999 Science 285 844-846) performed a set of perceptual experiments using portrait paintings by Chuck Close. Close's work is similar to the 'Lincoln' portraits of Harmon and Julesz (1973 Science 180 1194-1197) in that they are composite images consisting of coarsely sampled, individually painted, mostly homogeneous cells. Pelli showed that perceived shape was dependent on size, refuting findings that perception of this type is scale-invariant. In an attempt to broaden this finding we designed a series of experiments to investigate the interaction of 2-D scale and 3-D structure on our perception of 3-D shape. We present a series of experiments where field of view, 3-D object complexity, 2-D image resolution, viewing orientation, and subject matter of the stimulus are manipulated. On each trial, observers indicated if the depicted objects appeared to be 2-D or 3-D. Results for face stimuli are similar to Pelli's, while more geometrically complex stimuli show a further interaction of the 3-D information with distance and image information. Complex objects need more image information to be seen as 3-D when close; however, as they are moved further away from the observer, there is a bias for seeing them as 3-D objects rather than 2-D images. Finally, image orientation, relative to the observer, shows little effect, suggesting the participation of higher-level processes in the determination of the 'solidness' of the depicted object. Thus, we show that the critical image resolution depends systematically on the geometric complexity of the object depicted.     

From sensory processes to conscious perception

In recent years, cognitive neuroscientists have began to explore the process of how sensory information gains access to awareness. To further probe this process, event-related functional magnetic resonance imaging (fMRI) was used while testing subjects with a paradigm known as the "attentional blink." In this paradigm, visually presented information sporadically fails to reach awareness. It was found that the magnitude and time course of activation within the anterior cingulate (BA 32), medial prefrontal cortex (BA 9), and frontopolar cortex (BA 10) predicted whether or not information was consciously perceived during the critical period for the attentional blink. These results are discussed in light of a neural framework for conscious processing.     

Drug treatment of epilepsy: when does it fail and how to optimize its use?

Although modern community-based studies have shown that a majority of people with newly diagnosed epilepsy will enter long-term remission, seizures remain refractory to treatment in a substantial proportion of this population--perhaps as much as 40%. A consensus is being reached that, for operational purposes, pharmacoresistance can be suspected when two appropriately chosen, well-tolerated, first-line antiepileptic drugs (AEDs) or one monotherapy and one combination regimen have failed due to lack of efficacy. Poor prognostic factors include lack of response to the first AED, specific syndromes, symptomatic etiology, family history of epilepsy, psychiatric comorbidity, and high frequency of seizures. These observations suggest that prognosis can often be determined early in the course of the disorder. We propose a management paradigm that aims to maximize the chance of successful AED therapy, including the early use of "rational polytherapy" for patients not responding to monotherapy, and to identify efficiently patients suitable for "curative" resective surgery, in particular those with mesial temporal lobe epilepsy. An orderly approach to each epilepsy syndrome will optimize the chance of perfect seizure control and help more patients achieve a fulfilling life.     

Attention and inhibition in bilingual children: evidence from the dimensional change card sort task

In a previous study, a bilingual advantage for preschool children in solving the dimensional change card sort task was attributed to superiority in inhibition of attention (Bialystok, 1999). However, the task includes difficult representational demands to encode and interpret the task stimuli, and bilinguals may also have profited from superior representational abilities. This possibility is examined in three studies. In Study 1, bilinguals outperformed monolinguals on versions of the problem containing moderate representational demands but not on a more demanding condition. Studies 2 and 3 demonstrated that bilingual children were more skilled than monolinguals when the target dimensions were perceptual features of the stimulus and that the two groups were equivalent when the target dimensions were semantic features. The conclusions are that bilinguals have better inhibitory control for ignoring perceptual information than monolinguals do but are not more skilled in representation, confirming the results of the original study. The results also identify the ability to ignore an obsolete display feature as the critical difficulty in solving this task.