Discriminative properties of morphine that modulate associations between tastes and lithium chloride

Wistar rats learned to withhold consumption of a target solution when morphine preceded presentation of the target solution and lithium chloride (LiCl) and to consume the same target solution when saline preceded the presentation of the solution. After this serial feature discrimination training, morphine did not block the formation of a Pavlovian association between saccharin and LiCl but did suppress consumption of familiar tap water. After Pavlovian conditioning, morphine blocked the formation of an association between saccharin and LiCl but did not suppress consumption of a familiar tap water solution. The roles of morphine and saline can be interchanged. It appears that the morphine discriminative stimulus is calling up a representation of neither the conditioned stimulus nor the unconditional stimulus alone, but rather a modified representation of some aspect of their association.     

The effects of varying fins in Müller-Lyer and Holding illusions

Summary Five experiments were conducted to determine how distortion of spatial position induced by unidirectional Müller-Lyer fins varied as a function of angle and length of fins. Research employing Cornsweet's staircase method yielded ambiguous results, but psychophysical methods of magnitude estimation, paired comparisons, and production showed conclusively that distortions of position are affected by angle and length of fins in a manner similar to that found in distortions of length. It was concluded that similar strategies are employed in processing attributes of length and position and that a theory based on averaging of attributes within an attentional field describes the performance of real observers.Experiments 1 and 2 were reported in a Master's thesis submitted by Nancy Smith to the University of Manitoba in 1987.     

Mini-Review; Stress Genes: An Introductory Overview

Molecular sequence data, made available in the last 15 years or so, have led to the classification of living cells into three phylogenetic domains: Bacteria, Archaea, and Eucarya. All the organisms that have been tested belonging to either domain were capable of mounting a stress response with essentially the same characteristics, regardless of the stressor. The protagonists in the cell's stress response are the stress genes and their protein products. Some of the latter are molecular chaperones. Under physiological conditions, these chaperones aid other cellular proteins to fold properly and achieve a native -functional- configuration, and to translocate from the place of synthesis to the cell's locale in which they will operate. In a stressed cell, the stress proteins that are chaperones protect other molecules from denaturation and help those partially damaged to regain a functional configuration. Thus, cell death is avoided and recovery is enhanced. The study of stress genes and proteins has progressed considerably in organisms belonging to the domains Bacteria and Eucarya. Less is known about the archaeal stress genes. Here, research with an organism from the Archaea is discussed, focusing on the stress genes of the hsp70 (dnaK) locus. Future perspectives for basic and applied research within the health sciences and biotechnology industries are presented.     

Evaluating the Impact of a National AIDS Prevention Radio Campaign in St. Vincent and the Grenadines1

Based on extensive formative research in the three Eastern Caribbean countries of St. Lucia, St. Vincent and the Grenadines, and Grenada (Fishbein, Middlestadt, & Trafimow, 1993; Fishbein, Trafimow, et al., 1993), a three-nation, mass media, condom use campaign was developed. In order to assess the impact of the campaign, a follow-up survey was conducted in St. Vincent and the Grenadines. This paper examines the effectiveness of the campaign by comparing responses on this survey by respondents who were or were not exposed to the campaign. A statistically significant impact of exposure to the campaign was obtained, indicating that a well-designed, empirically based, mass media campaign can be an effective tool in the battle to prevent the spread of AIDS.     

Exposure-based models of human parsing: Evidence for the use of coarse-grained (nonlexical) statistical records

Several current models of human parsing maintain that initial structural decisions are influenced (or tuned) by the listener's or reader's prior contact with language. The precise workings of these models depend upon the grain, or level of detail, at which previous exposures to language are analyzed and used to influence parsing decisions. Some models are premised upon the use of fine-grained records (such as lexical cooccurrence statistics). Others use coarser measures. The present paper considers the viability of models based exclusively on the use of fine-grained lexical records. The results of several studies are reviewed and the evidence suggests that, if they are to account for the data, experience-based parsers must draw upon records or representations that capture statistical regularities beyond the lexical level. This poses problems for several parsing models in the literature.Aspects of this work were supported by ESRC grant No. R0023 4062 to Don Mitchell, by a Spanish Government grant DGICVT No. PB-92-0656-C04-02 to Fernando Cuetos, and by the Belgian National Fonds voor Wetenschappelijk Onderzoek, of which Marc Brysbaert is a Research Associate. We are grateful to Chuck Clifton, Barbara Hemforth, Martin Pickering, Matt Traxler, and an anonymous reviewer-all of whom made helpful comments on an earlier draft of the paper.     

PREVENTION OF DEPRESSIVE SYMPTOMS IN SCHOOLCHILDREN:

Abstract— After teaching cognitive and social-problem-solving techniques designed to prevent depressive symptoms, we followed 69 fifth- and sixth-grade children at risk for depression for 2 years. We compared these children with 49 children in a matched no-treatment control group The prevention group re- ported fewer depressive symptoms through the 2-year follow-up, and moderate to severe symptoms were reduced by half. Surprisingly, the effects of the prevention program grew larger after the program was over. We suggest that psychological immunization against depression can occur by leaching cognitive and social skills to children as they enter puberty     

Aggressivity,inattention, hyperactivity,and impulsivity in boys at high and low risk for substance abuse

Aggressivity, inattention, hyperactivity, and impulsivity are cardinal dimensions of externalizing behavior problems of childhood. They are diagnostic and clinical features of childhood disorders, and are thought to be linked to the subsequent development of adult disorders such as substance abuse (SA). Little is known, however, about the convergent and discriminant validity of these four constructs. We used multiple measures to develop indices of aggressivity, inattention, hyperactivity, and impulsivity in a sample of 10- to 12-year-old boys (N=183) with and without a family history of SA. Data were taken from mother reports, child reports, teacher reports, and laboratory tasks. The study aims were (1) to test the convergent and discriminant validity of aggressivity, inattention, hyperactivity, and impulsivity; (2) to examine whether the data were consistent with a model specifying the four constructs as indicators of one superordinate factor; and (3) to differentiate boys with and without a family history of SA in construct scores. The results supported the convergent and discriminant validity of the four constructs. Although discriminable, the constructs covaried strongly and were consistent with a model specifying them as indicators of a single superordinate factor. Boys with a family history of substance abuse scored higher than control boys on aggressivity, inattention, and impulsivity scores, but the groups did not differ on hyperactivity scores. The results are discussed in terms of the role of childhood behavior problems in vulnerability to SA.This work was supported by the National Institute on Drug Abuse grant No. DA 05605.     

Temporal coordination of alternative and simultaneous aiming movements of constrained timing structure

Two experiments are reported addressing the preparation and initiation of movements with equal or unequal timing properties for both hands. Temporal coordination was examined in two movement tasks: one in which both hands performed the movements simultaneously (simultaneous aiming task) and one in which only one alternative of two possible movements was executed (choice aiming task). For each task a different group of subjects was used. Besides the timing relationships between both movements, the effects of preparation interval (1, 3, and 5 s), the average velocity (7, 14, 17.5, and 70 cm/s), the presence of advance information about the required velocity of the movement(s), and practice were investigated. Based on the common- and the specific-timing notions, distinct hypotheses were tested as to the effects of the variables on the temporal coordination as revealed by reaction time. A main result was that the effects of timing differences between the hands was task specific. For the choice task the data are in agreement with the common-timing notion of coordination, i. e., only one timing demand at a time can be prepared, whereas in the simultaneous task evidence was obtained for the specific-timing notion, i. e., independent preparation and initiation of different timing properties for the hands. However, it is argued that the results of the choice task probably do not reflect a general inability to prepare movements of different timing requirements for both hands, but is related to a task-specific strategy of selective preparation.