Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures

Knowledge about cognitive late effects in survivors of childhood acute lymphoblastic leukemia (ALL) is largely based on standardized neuropsychological measures and parent reports. To examine whether cognitive neuroscience paradigms provided additional insights into neurocognitive and behavioral late effects in ALL survivors, we assessed cognition and behavior using a selection of cognitive neuroscience tasks and standardized measures probing domains previously demonstrated to be affected by chemotherapy.

130 ALL survivors and 158 control subjects, between 8 and 18 years old at time of testing, completed the n-back (working memory) and stop-signal (response inhibition) tasks. ALL survivors also completed standardized measures of intelligence (Wechsler Intelligence Scales [WISC-IV]), motor skills (Grooved Pegboard), math abilities (WIAT-III), and executive functions (Delis–Kaplan Executive Function System). Parents completed behavioral measures of executive functions (Behavior Rating Inventory of Executive Function [BRIEF]) and attention (Conners-3).

ALL survivors exhibited deficiencies in working memory and response inhibition compared with controls. ALL survivors also exhibited deficits on WISC-IV working memory and processing speed, Grooved Pegboard, WIAT-III addition and subtraction fluency, and numerical operations, as well as DKEFS number-letter switching. Parent reports suggested more attention deficits (Conners-3) and behavioral difficulties (BRIEF) in ALL survivors compared with referenced norms. Low correspondence between standardized and experimental measures of working memory and response inhibition was noted.

The use of cognitive neuroscience paradigms complements our understanding of the cognitive deficits evident after treatment of ALL. These measures could further delineate cognitive processes involved in neurocognitive late effects, providing opportunities to explore their underlying mechanisms.     

Psychoanalysis and the academy: Reflections on undergraduate teaching1

Abstract

This article addresses both the rewards and the daunting complexities of teaching psychoanalysis to undergraduates in the USA, where the idea of a university as a site for the cultivation of the life of the mind is under siege. The essay recommends a close critical reading of key Freudian texts, the establishment of a classroom atmosphere of trust, genuine respect for expectable student skepticism, and the capacity to wait as dystonic ideas gradually take hold and reveal their worth. Speed, a ubiquitous feature and a questionable desideratum of twenty-first century US culture, as well as facile cleverness, a desideratum within academia, tell against the psychoanalytic process, which is long, slow, halting, laborious, and painful, but a process that can, at best, open what has heretofore been sealed.     

Religion,Secular Humanism,and Atheism: Multi‐Institutional Politics and the USAFA Cadets’ Freethinkers Group

The recent emergence of atheist movements despite marginalization and distrust by a majority of Americans has been explained as a successful deployment of identity politics, but scholars have less often considered the importance of how identity and power intersect with political opportunity occurring within organizational and religious fields. Analyzing the case of the U.S. Air Force Academy (USAFA) Cadet Freethinkers Group, we demonstrate that although it encountered opportunity in the organizational shock of the 2004 USAFA proselytism controversy, this opportunity was not a blank check, but instead afforded some possibilities for action and not others. Freethinkers’ actions to secure official recognition were limited by (1) their low placement in the chain of command and (2) a collective identity inclusive of secular humanism and atheism, which did not produce enough unity to take collective actions risking punishment, and created ambiguity vis‐à‐vis religion that allowed USAFA administrators to accept or deny their institutional membership claims through appeal, respectively, to functional or substantive definitions of religion.     

Spiritual Openness,Revisiting a Potentially Important Aspect of Spirituality: Scale Review and Revision

Religiousness and spirituality (R/S) exert important influences on individuals across a range of domains. Spiritual Openness is theoretically linked with the personality trait of Openness to Experience, suggesting promise for future research. Using responses from 366 undergraduates on the Spiritual Experience Index-Revised (SEI-R: subscales of Spiritual Openness and Spiritual Support), analyses evaluated and revised the SEI-R, deleting poor items and generating a 10-item measure. The new SEI-S exhibits better psychometric properties and reduced participant burden, and subscales displayed a curvilinear relationship in which increases in Spiritual Openness showed a trade-off in levels of Spiritual Support.     

Unending Narrative,One-sided Empathy,and Problematic Contexts of Interaction in David Foster Wallace’s “The Depressed Person”

In 1997, David Foster Wallace published “The Depressed Person,” a short story about a privileged, deeply unhappy woman dedicated to exploring and recounting the texture and etiology of her chronic depression. This essay argues that “The Depressed Person” challenges the long-standing assumption that narrativizing the pain of depression is crucial to overcoming it, and the contemporary view that empathic responses from others promote recovery of the depressed. Taken together, these two critiques inform Wallace’s portrayal of chronic depression as an interactive phenomenon that is articulated, sustained, and regenerated through problematic contexts of interaction. Written at a time when public knowledge of and talk about depression was surging, “The Depressed Person” holds an important, if presently under-recognized place, in the expansive corpus of depression texts that emerged in the 1990s.     

A meta‐analysis of the relationship between socioeconomic status and executive function performance among children

The relationship between childhood socioeconomic status (SES) and executive function (EF) has recently attracted attention within psychology, following reports of substantial SES disparities in children's EF. Adding to the importance of this relationship, EF has been proposed as a mediator of socioeconomic disparities in lifelong achievement and health. However, evidence about the relationship between childhood SES and EF is mixed, and there has been no systematic attempt to evaluate this relationship across studies. This meta‐analysis systematically reviewed the literature for studies in which samples of children varying in SES were evaluated on EF, including studies with and without primary hypotheses about SES. The analysis included 8760 children between the ages of 2 and 18 gathered from 25 independent samples. Analyses showed a small but statistically significant correlation between SES and EF across all studies (r_random = .16, 95% CI [.12, .21]) without correcting for attenuation owing to range restriction or measurement unreliability. Substantial heterogeneity was observed among studies, and a number of factors, including the amount of SES variability in the sample and the number of EF measures used, emerged as moderators. Using only the 15 studies with meaningful SES variability in the sample, the average correlation between SES and EF was small‐to‐medium in size (r_random = .22, 95% CI [.17, .27]). Using only the six studies with multiple measures of EF, the relationship was medium in size (r_random = .28, 95% CI [.18, .37]). In sum, this meta‐analysis supports the presence of SES disparities in EF and suggests that they are between small and medium in size, depending on the methods used to measure them.     

Perceived responsibility for learning,self-efficacy,and sources of self-efficacy in mathematics: a study of international baccalaureate primary years programme students

The purpose of this study was to assess the interrelationship of elementary students’ perceived responsibility for learning, self-efficacy, and sources of self-efficacy in mathematics, and differentiation as a function of gender and grade level. Participants in this study included 442 third-, fourth-, and fifth-grade students from U.S. International Baccalaureate schools. Self-report measures were used to assess key study variables. Students in grade five reported higher levels of mathematics self-efficacy and perceived responsibility for learning than those in grade three. Grade four students also reported higher levels of perceived responsibility than grade three students. In addition, regression results revealed that mastery experience, vicarious experience, social persuasion, and physiological state accounted for a significant amount of variance in students’ mathematics self-efficacy, with social persuasion being the strongest predictor. Educational implications for practice within the context of International Baccalaureate schools are discussed.     

Deliberation in citizenship education: how the school context contributes to the development of an open classroom climate

Schools are expected to contribute to preparing students for engaged citizenship. Research shows that open classroom discussions on political issues have a positive effect on political attitudes and behaviour. However, a deeper understanding of why students perceive their classrooms as open for discussion is missing. The purpose of this study is to examine how deliberative democratic theory can be used to explain such perceptions. We argue that the openness of the discussion climate is positively affected by, on the one hand, a context of good student–teacher relations characterised by fairness and respect, and, on the other hand, by the level of collective efficacy, which is the perception of responsiveness of the school towards student demands. Using multilevel analyses on the European data of the International Civic and Citizenship Education Study (ICCS 2009), we find that these predictors are significant at the student level and the school level. This means that both the individual experience of a student as well as the average school’s score on good student–teacher relations and collective efficacy affect how students perceive the discussion climate. Our findings, based on high-quality survey data from 22 countries, are a significant contribution to clarifying the underlying mechanism leading to an open classroom climate. As such discussions have proven to be an effective way to stimulate political engagement, we conclude that a school context characterised by fairness and responsiveness, should not be overlooked by schools and policy.