Reading between the lines: Event-related brain potentials during natural sentence processing

Event-related potentials (ERPs) were recorded from subjects as they silently read 160 different seven-word sentences, presented one word at a time. Each sentence was in itself a natural, meaningful phrase. Substantial intersubject variability was observed in the ERP waveshapes following the words. More than half of the subjects generated P3 components to word stimuli, but those who did showed similar responses to repeated control presentations of a single word. In addition, it was found that all but the first word in the sentence elicited an ERP with a significant left-greater-than-right asymmetry in the late positivity over temporo-parietal regions. The ERPs to the last words were associated with more late positivity than those to the preceding words. One quarter of the sentences, at random, ended with a word printed in a typeface that was different from that of the preceding words. This infrequent change in typeface elicited a complex ERP having three consistent late positive components.     

TEMPORAL RELATIONSHIPS IN LANGUAGE1

Bref exposé d'une approche piagétienne à L'étude de L'acquisition du langage. Certains principes de base de la psychologie génétique qui s'appliquent également à ce domaine sont rappelés. La méthode d'interrogation qui en découle est présentée ainsi que les raisons qui ont amené les auteurs à envisager L'étude de L'acquisition de certaines structurations linguistiques à travers des épreuves de compréhension, de production et de répétition. La technique a pour but de saisir les changements qualitatifs dans les réponses des enfants (de 4 à 9 ans), dont on connaît le niveau de développement cognitif, déterminé par des épreuves propres à la psychologie génétique. A titre d'exemple une recherche récente est brièvement discutée. Elle porte sur la compréhension, la production et la répétition de phrases qui expriment une relation d'ordre temporel entre deux événements. L'accent est mis sur les résultats obtenus dans les épreuves de production qui sont les plus révélateurs du mode d'élaboration de cette structuration. Quelques particularités des réponses sont relevées, qui indiquent L'importance prêtée par les sujets aux valeurs aspectuelles des formes verbales. Une interprétation qui tient compte des données de la psychologie génétique est proposée.     

Exploring the Factor Structure of the Social Cognition and Object Relations–Global Rating Method: Support for Two- and Three-Factor Models

The Social Cognition and Object Relations Scales–Global Rating Method (SCORS–G) contains 8 scales for coding narrative content. This study explores the factor structure of this measure using college (n = 171), outpatient (n = 239), and inpatient (n = 78) samples. Participants told stories to the Thematic Apperception Test (TAT; Murray, 1943) cards. Stories were transcribed and coded by blind raters using the SCORS–G. Cases were randomly assigned to an exploratory or validation group. Exploratory factor analysis with the exploratory group suggested 2- and 3-factor models. The Emotional Investment in Relationships (EIR) scale did not obtain a primary loading on any factor and was not included in subsequentmodels. After modifications, confirmatory factor analysis indicated good-to-adequate fit for 2- and 3-factor models. Both models showed good fit in the validation group and met criteria for invariance across models. Findings indicated that some SCORS–G scales tap cognitive-structural elements, whereas others assess affective-relational components of narratives. We found mild support separating the affective-relational scales in terms of internal representations for the self and others and relationships. The results reported here indicate that clinicians and researchers can calculate a separate cognitive-structural composite score and an affective-relational composite score when using the SCORS–G to rate TAT stories.     

Looming Threats and Animacy: Reduced Responsiveness in Youth with Disrupted Behavior Disorders

Theoretical models have implicated amygdala dysfunction in the development of Disruptive Behavior Disorders (DBDs; Conduct Disorder/Oppositional Defiant Disorder). Amygdala dysfunction impacts valence evaluation/response selection and emotion attention in youth with DBDs, particularly in those with elevated callous-unemotional (CU) traits. However, amygdala responsiveness during social cognition and the responsiveness of the acute threat circuitry (amygdala/periaqueductal gray) in youth with DBDs have been less well-examined, particularly with reference to CU traits. 31 youth with DBDs and 27 typically developing youth (IQ, age and gender-matched) completed a threat paradigm during fMRI where animate and inanimate, threatening and neutral stimuli appeared to loom towards or recede from participants. Reduced responsiveness to threat variables, including visual threats and encroaching stimuli, was observed within acute threat circuitry and temporal, lateral frontal and parietal cortices in youth with DBDs. This reduced responsiveness, at least with respect to the looming variable, was modulated by CU traits. Reduced responsiveness to animacy information was also observed within temporal, lateral frontal and parietal cortices, but not within amygdala. Reduced responsiveness to animacy information as a function of CU traits was observed in PCC, though not within the amygdala. Reduced threat responsiveness may contribute to risk taking and impulsivity in youth with DBDs, particularly those with high levels of CU traits. Future work will need to examine the degree to which this reduced response to animacy is independent of amygdala dysfunction in youth with DBDs and what role PCC might play in the dysfunctional social cognition observed in youth with high levels of CU traits.     

The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives

Amyotrophic Lateral Sclerosis is a neurodegenerative disorder characterized primarily by motor network disruption. Extra-motor manifestations including executive functions, social cognition, and behavioral changes are now well recognized as important features of ALS, and are associated with frontotemporal and frontostriatal network disruption. However, the presence and characterization of language changes has received less attention. This systematic review characterizes the profile of reported language dysfunction in ALS. PRISMA guidelines were implemented to carry out and report the review. Current evidence suggests that areas of neuroanatomical disruption in ALS spread to language centers such as posterior, inferior frontal and superior temporal areas leading to deficits in word retrieval, syntactic and grammatical processing, and spelling. However, the majority of studies of language in ALS have been limited by the recruitment of small clinic-based prevalent samples and important questions remain regarding the incidence and progression of language impairment in ALS. Further studies from population-based incident cohorts will help to determine the range of language deficits in ALS, and how these relate to previously defined executive and behavioral sub-phenotypes.     

Working with Research Integrity—Guidance for Research Performing Organisations: The Bonn PRINTEGER Statement

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on the following key issues:

1. § 1.
   Providing information about research integrity
    
2. § 2.
   Providing education, training and mentoring
    
3. § 3.
   Strengthening a research integrity culture
    
4. § 4.
   Facilitating open dialogue
    
5. § 5.
   Wise incentive management
    
6. § 6.
   Implementing quality assurance procedures
    
7. § 7.
   Improving the work environment and work satisfaction
    
8. § 8.
   Increasing transparency of misconduct cases
    
9. § 9.
   Opening up research
    
10. § 10.
    Implementing safe and effective whistle-blowing channels
     
11. § 11.
    Protecting the alleged perpetrators
     
12. § 12.
    Establishing a research integrity committee and appointing an ombudsperson
     
13. § 13.
    Making explicit the applicable standards for research integrity
     

     

Construct and concurrent validity of the Cambridge neuropsychological automated tests in Portuguese older adults without neuropsychiatric diagnoses and with Alzheimer’s disease dementia

We aimed to analyze the construct and concurrent validity of the Rapid Visual Information Processing (RVP), Paired Associates Learning (PAL), Reaction Time (RTI), and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB®). Inclusion criteria were checked in a first session. The CANTAB and additional pencil-and-paper tests were administered within 1 week. The participants (aged 69–96 years) were 137 Portuguese adults without neuropsychiatric diagnoses and 37 adults with mild-to-moderate Alzheimer’s disease dementia. Comparisons were made between the CANTAB tests and between these tests and the Rey Complex Figure Test (RCFT), Verbal Fluency (VF) test, and some Wechsler Memory Scale-III and Wechsler Adult Intelligence Scale-III subtests. Most intra-test correlations were stronger than the CANTAB inter-test correlations. The RVP correlated more with VF animals (.44), the PAL with RCFT immediate recall (–.52), the RTI with RVP mean latency (.42), and the SWM with Spatial Span backward (–.39).     

Life Satisfaction and Character Strengths in Spanish Early Adolescents

This study of Spanish early adolescents aimed to extend knowledge about the relationship between character strengths and life satisfaction (LS) and to explore gender differences in the prediction of LS. A sample of 457 adolescents aged 11–14 years completed questionnaires to assess LS and 24 character strengths. Results from simple correlation analysis showed that 18 strengths were positively and significantly correlated with LS, the highest coefficients being those for love, hope, authenticity and persistence. However, since strengths are inter-correlated, regression modelling was performed in order to determine which of these strengths are the best predictors of LS, and to identify any gender differences in this association. The results showed that love and hope were the most relevant strengths for predicting LS, with a positive relationship being observed for both girls and boys. This finding highlights the importance of positive thinking and of maintaining positive relationships during early adolescence. Gender differences were observed, however, for authenticity as a predictor of LS. Specifically, this variable made a significant contribution to the model in girls, for whom higher scores on authenticity were associated with greater LS. This result is interpreted in terms of gender differences in the timing of maturation. The findings help to further our understanding of the association between subjective well-being and character strengths in early adolescence, a critical stage of human development. In addition, the results suggest that intervention programmes based on character strengths in this developmental stage should mainly target the so-called ‘strengths of the heart’.     

The Polish adaptation of the Early Childhood Behavior Questionnaire (ECBQ): Psychometric properties,age and gender differences and convergence between the questionnaire and the observational data

The main aim of the study was to determine the psychometric properties of the version of the Early Childhood Behavior Questionnaire (ECBQ) adapted to Polish culture. Since temperament in toddlers was being observed in a laboratory, an external validity of the ECBQ was also provided. Kagan’s observational paradigm was used to test 215 18-month-old children. Their parents completed the ECBQ twice, when the children were 26 and 30 months old. The results showed good internal consistency and confirmed the longitudinal stability of the scale. The same three-factor solution was found in the structure of the scale as in the original American study. The convergence between the observational and parent report data supported the ECBQ’s external validity. Similarities in the structure of the scale observed between the Polish and American data are discussed from a cross-cultural perspective. The usefulness of the Polish ECBQ and the limitations of the obtained results are discussed.     

Negative emotional processing induced by spoken scenarios modulates corticospinal excitability

Emotion is assumed to facilitate the preparation of behavioral responses to environmental stimuli. In the present study, we examined whether emotional processing induced by spoken scenarios of positive and negative content, related to the self or to other people, modulates corticospinal excitability. Motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in 20 volunteers indicated that processing of negative emotional content increased MEP amplitude, regardless of the perspective taken in the scenario. By contrast, positive emotional processing did not reliably alter MEP amplitude. These results provide the first TMS evidence that the auditory processing of emotionally negative information triggers action preparation.