The Mediation Myth

The mediation myth is the false belief that mediation is actually estimated in the typical mediation analysis. This myth is based on a trifecta of shortcomings: (1) the typical mediation study relies on an inadequate design; (2) the researcher uses a flawed analysis strategy; and (3) there is scant attention to assumptions that are required when estimating mediation. These problems stem from overgeneralizing the classical product method for estimating mediation and overreliance on statistical significance testing as a decision criterion in mediation analysis. The goals of this article are to (1) raise awareness of these difficulties among researchers and (2) provide a roadmap about design and analysis options for a more rigorous and scientifically valid approach to mediation analysis.     

The adrenergic receptor α-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD

There is resurgent interest in the psychiatric literature in endophenotypes, variables thought to more strongly reflect the effects of candidate genes than do manifest disorders. In a sample of 176 children with attention deficit hyperactivity disorder (ADHD) and 52 of their siblings, we examined the validity of several putative endophenotypes for ADHD that represent commonly used clinical measures of multiple cognitive/neuropsychological domains of executive functions (EFs). We review their distributional normality, their relations to ADHD symptoms in probands and unaffected siblings relative to nonADHD controls, and their correlation in siblings. We also tested the EF measures’ associations with the ADRA2A gene and whether they mediated or moderated the associations between ADHD and ADRA2A. Several EF measures showed association with ADRA2A, as well as moderation, but not mediation, of its association with ADHD. Implications of the results for evaluating the validity and utility of putative endophenotype measures and for finding candidate gene effects on ADHD are discussed.     

Acute alcohol effects on repetition priming and word recognition memory with equivalent memory cues

Acute alcohol intoxication effects on memory were examined using a recollection-based word recognition memory task and a repetition priming task of memory for the same information without explicit reference to the study context. Memory cues were equivalent across tasks; encoding was manipulated by varying the frequency of occurrence (FOC) of words in the study lists. Twenty-two female and male social drinkers (age 21-24 years) completed equivalent versions of the memory tasks in two counterbalanced sessions (alcohol challenge, no-alcohol). Alcohol and the FOC manipulation affected recollection-based memory processing, but not repetition priming. Results supported alcohol's dissociative effects on memory systems.     

The Relationship Between Blood Lead,Bone Lead and Child Intelligence

We report associations between serial measures of blood lead and intelligence in children age 10–12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with blood lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.     

The predictive validity of cognitive complexity measures on social perspective-taking and counseling communication

We compared the predictive validity of two cognitive complexity measures on two communication-relevant abilities: social perspective-taking and person-centered counseling. Forty-six undergraduates completed versions of Crockett's Role Category Questionnaire and Bieri et al.'s repertory grid task to measure cognitive complexity. Measures of social perspective-taking ability and person-centered counseling messages were also obtained from the subjects. Whereas Crockett's complexity measure was significantly and consistently related to the communication-related measures, Bieri's complexity measure was only marginally related to these same measures.     

Electroencephalographic registration of low concentrations of isoamyl acetate

Previous research has demonstrated electroencephalogram (EEG) changes in response to low-odor concentrations, resulting in near-chance detection. Such findings have been taken as evidence for olfaction without awareness. We replicated and extended previous work by examining EEG responses to water-water control, 0.0001, 0. 001, 0.01, and 1 ppm isoamyl acetate (IAA) in water paired with water only. Detection was above chance (>50%) for.001 and above, and alpha decreased only to those concentrations, suggesting that EEG changes corresponded to IAA awareness. However, when correct trial EEGs were compared to incorrect trial EEGs during.001 ppm, right posterior/central alpha decreased during incorrect trials and alpha decreased more globally (including frontal sites) during correct trials. These data may not reflect awareness or unawareness per se. Instead, results are discussed regarding activation of perceptual systems in the posterior region during incorrect trials and the activation of frontal action systems during a subset of correct trials.     

The relationship between blood lead, bone lead and child intelligence.

We report associations between serial measures of blood lead and intelligence in children age 10-12 years, half heavily exposed to lead from the prenatal period onward, and half relatively unexposed. For a subsample, we examine bone lead-IQ associations, comparing them with bone lead associations. Both blood and bone lead levels were associated with intelligence decrements, small relative to the contribution of social factors. For each doubling of Tib-Pb, Full Scale, Performance, and Verbal IQ decreased by an estimated 5.5, 6.2, and 4.1 points, respectively. Bone lead-IQ associations were stronger than those for blood lead, which nonetheless provide robust analogues. Current BPb, easy to obtain, provides a useful means for assessing Pb exposure/IQ associations.