The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials

Antiepileptic drugs (AEDs) have diverse psychotropic profiles. Some AEDs have proven to be efficacious in the treatment of mood disorders, especially bipolar disorder. Others are ineffective as primary treatments but may be useful adjuncts for mood disorders or comorbid conditions. Valproate (acute mania and mixed episodes), carbamazepine (acute mania and mixed episodes), and lamotrigine (maintenance to delay recurrence) have United States Food and Drug Administration indications for the treatment of bipolar disorder. This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling.     

Effects of phoneme repertoire

In three experiments, listeners detected vowel or consonant targets in lists of CV syllables constructed from five vowels and five consonants. Responses were faster in a predictable context (e.g., listening for a vowel target in a list of syllables all beginning with the same consonant) than in an unpredictable context (e.g., listening for a vowel target in a list of syllables beginning with different consonants). In Experiment 1, the listeners’ native language was Dutch, in which vowel and consonant repertoires are similar in size. The difference between predictable and unpredictable contexts was comparable for vowel and consonant targets. In Experiments 2 and 3, the listeners’ native language was Spanish, which has four times as many consonants as vowels; here effects of an unpredictable consonant context on vowel detection were significantly greater than effects of an unpredictable vowel context on consonant detection. This finding suggests that listeners’ processing of phonemes takes into account the constitution of their language’s phonemic repertoire and the implications that this has for contextual variability.     

Phonological cues to open- and closed-class words in the processing of spoken sentences

Evidence is presented that (a) the open and the closed word classes in English have different phonological characteristics, (b) the phonological dimension on which they differ is one to which listeners are highly sensitive, and (c) spoken open- and closed-class words produce different patterns of results in some auditory recognition tasks. What implications might link these findings? Two recent lines of evidence from disparate paradigms—the learning of an artificial language, and natural and experimentally induced misperception of juncture—are summarized, both of which suggest that listeners are sensitive to the phonological reflections of open- vs. closed-class word status. Although these correlates cannot be strictly necessary for efficient processing, if they are present listeners exploit them in making word class assignments. That such a use of phonological information is of value to listeners could be indirect evidence that open- vs. closed-class words undergo different processing operations.     

Self-monitoring and the association between confidence and accuracy

A personality prediction task in which a confidence rating accompanies each judgment is used to test the hypotheses that self-monitoring is positively related to accuracy, positively related to confidence, negatively related to calibration, and capable of acting as a moderator of the relationship between accuracy and confidence. Data from 101 university students support two of these predictions: High self-monitors exhibit more confidence and poorer calibration than low self-monitors. Concern for appropriateness is found to be unrelated to all other variables studied. Results are discussed in the context of socioanalytic theory and recent theories of self-presentation, affectivity, and the relationship between illusions and well-being.     

Concern for appropriateness as a moderator variable in the statistical explanation of self-reported use of alcohol and marijuana

Two studies examine the Concern for Appropriateness Scale (Lennox & Wolfe, 1984) as a likely moderator of dispositional and environmental variables associated with self-reported use of alcohol and marijuana by college and precollege students. In Study 1, data from 408 upper division students show that concern score interacts significantly with religiosity in analyses of use of both drugs, but not with any of 11 other dispositional variables nor with drug-specific environment predictors in analyses of use of either drug. In Study 2, data from 242 recent high school graduates show that concern score interacts significantly with religiosity and drug-specific environment in the explanation of alcohol use but not in the explanation of marijuana use. All of the significant interactions are in the predicted direction. Results therefore suggest that the concern scale is valid for some of its intended purposes.     

Construct validity of the Concern For Appropriateness scale

Construct validity of the Concern For Appropriateness scale (CFA; Lennox & Wolfe, 1984), a measure of the tendency to adopt protective self-presentation styles, is examined using a multitrait-multimethod approach. Self-ratings on the CFA and ratings by suitemates constitute the two methods, and concern for appropriateness, interpersonal trust, and boredom susceptibility are assessed with each. Multitrait-multimethod analysis shows that the CFA scale exhibits convergent validity against peer ratings and discriminant validity against boredom susceptibility, the only other variable demonstrating convergence. Results indicate that the CFA exhibits construct validity and might therefore prove useful as an operationalization for self-presentation tendencies.     

The abstract representations in speech processing

Speech processing by human listeners derives meaning from acoustic input via intermediate steps involving abstract representations of what has been heard. Recent results from several lines of research are here brought together to shed light on the nature and role of these representations. In spoken-word recognition, representations of phonological form and of conceptual content are dissociable. This follows from the independence of patterns of priming for a word's form and its meaning. The nature of the phonological-form representations is determined not only by acoustic-phonetic input but also by other sources of information, including metalinguistic knowledge. This follows from evidence that listeners can store two forms as different without showing any evidence of being able to detect the difference in question when they listen to speech. The lexical representations are in turn separate from prelexical representations, which are also abstract in nature. This follows from evidence that perceptual learning about speaker-specific phoneme realization, induced on the basis of a few words, generalizes across the whole lexicon to inform the recognition of all words containing the same phoneme. The efficiency of human speech processing has its basis in the rapid execution of operations over abstract representations.     

Self-Images without Awareness and Projective Methods of Personality Assessment

Ss' responses to tachistoscopic exposures of self-photographs have been suggested as one approach to self-images without awareness. Sixty-three Ss completed a Q sort for themselves and after tachistoscopic exposure of their own and control photographs, for the persons in the photographs. Ss also completed the Structured-Objective Rorschach Test and Rotter Incomplete Sentences Blank. The self was sorted most favorably, the control tachistoscopic exposure significantly less favorably, and the self tachistoscopic exposure significantly less favorably than the control. These differences were found to be related to sex and adjustment measured with the Rotter. The SORT correlated insignificantly with Q sort and Rotter.     

How effective are the cross-examination and expert testimony safeguards? Jurors' perceptions of the suggestiveness and fairness of biased lineup procedures

Mock jurors (N = 800) viewed a videotaped trial that included information about a lineup identification procedure. Suggestiveness of the eyewitness identification procedure varied in terms of foil, instruction, and presentation biases. Expert testimony regarding the factors that influence lineup suggestiveness was also manipulated. Criteria included juror ratings of lineup suggestiveness and fairness, ratings of defendant culpability, and verdicts. Jurors were sensitive to foil bias but only minimally sensitive to instruction and presentation biases. Expert testimony enhanced juror sensitivity only to instruction bias. These results have implications for the effectiveness of cross-examination and expert testimony as safeguards against erroneous convictions resulting from mistaken identifications.