Cultivating a healthy neuro‐immune network: A health psychology approach

The field of psychoneuroimmunology (PNI) examines interactions among psychological and behavioral states, the brain, and the immune system. Research in PNI has elegantly documented effects of stress at multiple levels of the neuro‐immune network, with profound implications for both physical and mental health. In this review, we consider how the neuro‐immune network might be influenced by “positive” psychological and behavioral states, focusing on positive affect, eudaimonic well‐being, physical activity, and sleep. There is compelling evidence that these positive states and behaviors are associated with changes in immune activity in the body, including reductions in peripheral inflammatory processes relevant for physical health. Growing evidence from animal models also suggests effects of positive states on immune cells in the brain and the blood‐brain barrier, which then impact critical aspects of mood, cognition, and behavior. Tremendous advances are being made in our understanding of neuro‐immune dynamics; one of the central goals of this review is to highlight recent preclinical research in this area and consider how we can leverage these findings to investigate and cultivate a healthy neuro‐immune network in humans.     

Benefit Finding and Physical Health: Positive Psychological Changes and Enhanced Allostasis

Many individuals who undergo stressful life events report that they have derived some positive benefit from the experience. Although the majority of research on benefit finding has focused on its psychological correlates, there is intriguing evidence that benefit finding may also have effects on physical health. In this paper, we review the emerging literature on benefit finding and physical health and present an integrative model in which we identify specific psychological and physiological pathways through which benefit finding may influence physical health outcomes. In particular, we consider the hypothesis that benefit finding may involve changes in a number of psychological domains – namely, changes in appraisal and coping processes, relationships, goals and priorities, and positive affect – that lead to a state of enhanced allostasis, buffering against negative effects of catabolic stress responses and promoting activity in restorative physiological systems. Empirical evidence for this model is reviewed, focusing on studies that have examined positive psychological constructs relevant to benefit finding and their effects on stress reactivity, recovery, and habituation, as well as restorative processes.     

A model for predicting the outcomes of basketball games

We investigated the task of predicting the outcomes of sporting events, in particular, basketball games. In two experiments, college students predicted the outcomes of a series of National Basketball Association (NBA) games. Following each prediction, the subject received feedback in the form of the actual outcome of the NBA game. After a period of initial learning about the relative strengths of the teams, the subjects were surprisingly successful in their predictions. We examined expert–novice differences by comparing the published predictions of professional oddsmakers to the predictions of the experimental subjects. The average predictions by the subjects were approximately as accurate as the predictions of experts. Finally, we applied a mathematical model, developed originally as an account of simpler learning experiments, to the subjects' responses. We found that the course of the subjects' learning about the teams was well-described by this model.     

Storage and later recognition of exemplars of concepts

This paper concerns the problem of abstraction: whether when we encounter several exemplars of a concept, we retain only the abstracted concept, only the exemplars, or both. Although many studies concur that both are stored, a recent article argued strongly that only the abstracted concept is stored. The present study, aimed at replication of this recent finding, follows the earlier procedural details but adds appropriate controls and uses simpler material. A set of 24 exemplars of four concepts, in the form of four-tuples of letters and numbers, was presented to Ss who, after presentation, rated a larger set of exemplars for recognition. One group of Ss experienced the conceptual exemplars; control group Ss experienced items that were similar in composition but not exemplars of a concept. Two major results appeared: Unlike the study on which this was based, all Ss were able to distinguish those items that were originally experienced from those that were not. And, the more completely an exemplar fit the concept (the longer the item), the more confident the S was that it had been presented. In contrast, in the control condition, the longer the item, the more confident the S was that it had not been presented earlier. Two models are described to account for these results. One is based on the S's initial storage of the exemplars in a concept-plus-correction format; the other is based on a procedure whereby the S can make recognition judgments without having previously abstracted and retained the concepts.     

Application of a model to paired-associate learning

The proposal is made to consider a paired-associate item as becoming conditioned to its correct response in all-or-none fashion, and that prior to this conditioning event the subject guesses responses at random to an unlearned item. These simple assumptions enable the derivation of an extensive number of predictions about paired-associate learning. The predictions compare very favorably with the results of an experiment discussed below.This research was supported by a grant, M-3849, from the National Institutes of Mental Health, United States Public Health Service.     

Naturally occurring mood and learning: comment on Hasher, Rose, Zacks, Sanft, and Doren

We comment on the article by Hasher, Rose, Zacks, Sanft, & Doren (1985) in which they failed to find mood-congruent learning (MCL). MCL occurs whenever subjects learn more about materials that are congruent with their moods (e.g., depressed subjects learn more sad material). Hasher et al. failed to observe MCL with normal college students who scored high versus low on the Beck Depression Inventory and an affect checklist; in contrast, positive MCL has been observed with clinically depressed patients and with normals given laboratory mood inductions. Hasher et al. argue that moderately depressed normal students may be qualitatively different from clinically depressed patients and mood-induced subjects. Although we accept the findings of Hasher et al., we think it is also plausible that MCL may be a general though small effect which is present among normal college students as well.     

Enhancing spatial skills of preschoolers from under-resourced backgrounds: A comparison of digital app vs. concrete materials

Spatial skills support STEM learning and achievement. However, children from low-socioeconomic (SES) backgrounds typically lag behind their middle- and high-SES peers. We asked whether a digital educational app—designed to mirror an already successful, spatial assembly training program using concrete materials—would be as effective for facilitating spatial skills in under-resourced preschoolers as the concrete materials. Three-year-olds (N = 61) from under-resourced backgrounds were randomly assigned to a business-as-usual control group or to receive 5 weeks of spatial training using either concrete, tangible materials or a digital app on a tablet. The spatial puzzles used were an extension of items from the Test of Spatial Assembly (TOSA). Preschoolers were pretested and posttested on new two-dimensional (2D) TOSA trials. Results indicate that both concrete and digital spatial training increased performance on the 2D-TOSA compared to the control group. The two trainings did not statistically differ from one another suggesting that educational spatial apps may be one route to providing early foundational skills to children from under-resourced backgrounds.     

Antagonistic pleiotropy at the human IL6 promoter confers genetic resilience to the pro-inflammatory effects of adverse social conditions in adolescence

The authors tested the evolutionary genetic hypothesis that the functional form of an asymmetrically risky Gene × Environment interaction will differ as a function of age-related antagonistic pleiotropy (i.e., show opposite effects in young vs. old individuals). Previous studies have identified a polymorphism in the human IL6 promoter (rs1800795; IL6-74 G/C) that interacts with adverse socioenvironmental conditions to promote chronic inflammation in older adults (elevated C-reactive protein). This study identifies a protective effect of the same polymorphism in 17- to 19-year-old adolescents confronting socioeconomic adversity. Over 60% of the environmental risk contribution to the IL6 × Socioeconomic Status interaction could be accounted for by interpersonal stress and adult role burden. Thus, the IL6-174G allele does not represent an undifferentiated risk factor but instead sensitizes inflammatory biology to socioenvironmental conditions, conferring either genetic vulnerability or resilience depending on the developmental "somatic environment" that interacts with social conditions to influence gene expression.     

Adaptive categorization in unsupervised learning

In 3 experiments, the authors provide evidence for a distinct category-invention process in unsupervised (discovery) learning and set forth a method for observing and investigating that process. In the 1st 2 experiments, the sequencing of unlabeled training instances strongly affected participants' ability to discover patterns (categories) across those instances. In the 3rd experiment, providing diagnostic labels helped participants discover categories and improved learning even for instance sequences that were unlearnable in the earlier experiments. These results are incompatible with models that assume that people learn by incrementally tracking correlations between individual features; instead, they suggest that learners in this study used expectation failure as a trigger to invent distinct categories to represent patterns in the stimuli. The results are explained in terms of J. R. Anderson's (1990, 1991) rational model of categorization, and extensions of this analysis for real-world learning are discussed.