How Does Neurobiological Research Influence Psychoanalytic Treatments?—Clinical Observations and Reflections From a Study on the Interface of Clinical Psychoanalysis and Neuroscience

One of the counterarguments against empirical research in psychoanalysis is that research negatively influences the treatment situation. In this paper, the impact of a neurobiological study on psychoanalytically oriented treatments is presented from three different perspectives: patients' views, a study group of participating psychoanalysts and a clinical case example. Twenty chronically depressed patients, 20 healthy controls and 16 psychoanalysts participated in the project on research. Results show a clear influence of the neurobiological study on the course of treatments. Patients consistently reported that study participation had a positive impact on their treatment experiences. However, study participation was conflictual for the psychoanalysts and forced them to carefully reflect on their unconscious and conscious involvement to establish a psychoanalytic stance independent from empirical research.     

Dopaminergic and prefrontal contributions to reward-based learning and outcome monitoring during child development and aging

In many instances, children and older adults show similar difficulties in reward-based learning and outcome monitoring. These impairments are most pronounced in situations in which reward is uncertain (e.g., probabilistic reward schedules) and if outcome information is ambiguous (e.g., the relative value of outcomes has to be learned). Furthermore, whereas children show a greater sensitivity to external outcome information, older adults focus less on a rapid differentiation of rewarding outcomes. In this article, we review evidence for the idea that these phenomenologically similar impairments in learning and outcome monitoring in children and older adults can be attributed to deficits in different underlying neurophysiological mechanisms. We propose that in older adults learning impairments are the result of reduced dopaminergic projections to the ventromedial prefrontal cortex, which lead to less differentiated representations of reward value. In contrast, in children, impairments in learning can be primarily attributed to deficits in executive control, which may be due to a protracted development of the dorsal medial and lateral prefrontal cortices. We think that this framework maps well onto recent neurophysiological models of reward processing and is plausible from a broader developmental perspective.     

Recognising faces seen alone or with others: why are two heads worse than one?

The ability to identify an unfamiliar target face from an identity lineup declines when the target is accompanied by a second face during visual encoding. This two-face disadvantage is still little studied and its basis remains poorly understood. We investigated several possible explanations for this phenomenon. Experiments 1 and 2 varied the number of potential targets (1 or 2) and the number of faces in a lineup (5 or 10) to explore if this effect arises from the number of identity comparisons that need to be made to detect a target in a lineup. We also explored if this effect arises from an uncertainty concerning which is the to-be-identified target in two-face displays, by cueing the relevant face during encoding. In experiment 3 we then examined whether the two-face disadvantage reflects the depth of face encoding or a memory effect. The results show that this effect arises from the additional comparisons that are necessary to compare two potential targets to an identity lineup when memory demands are minimised (experiment 1), but it reflects a difficulty in remembering several faces when targets and lineups cannot be viewed simultaneously (experiments 2 and 3). However, in both cases the two-face disadvantage could not be eliminated fully by cueing the target. This hints at a further possible locus for this effect, which might reflect perceptual interference during the initial encoding of the target. The implications of these findings are discussed.     

Empathy, values, morality and Asperger's syndrome

The aims of this study were, first, to re-address the issue of empathy among people with autism conditions; second, to explore the relationships between empathy and values among autistic populations and controls; and third, to explore the capacity for moral agency among those affected by autism. We compared responses of an Asperger group (N = 41) and a control group (N = 139) to measures of self-reported empathy (Davis's IRI) and value priorities (Schwartz's PVQ). Control group results were largely in line with previous studies, such that empathy subscales of perspective taking and empathic concern showed their strongest positive and negative relations to the Schwartz self-transcendence/self-enhancement dimensions. Results for the Asperger group showed that although on the one hand there were self-reported difficulties in perspective taking and the cognitive recognition of affect, and that on the other hand there were less connections between the empathy and value measures, there was nevertheless a comparable prioritization of moral values. Conclusions suggest that different people may acquire moral values through different mechanisms.     

Increasing perceived variability reduces prejudice and discrimination

We examined whether increasing individuals' perceived variability of an out-group reduces prejudice and discrimination toward its members. In a series of 4 laboratory and field experiments, we attracted participants' attention to either the homogeneity or the heterogeneity of members of an out-group, and then measured their attitudes or behaviors. Perceived variability was manipulated by making subgroups salient, by portraying the out-group members as having diverse opinions, by making salient that out-group members have different characteristics, or by asking participants to think about differences among out-group members. Prejudice and discrimination were measured in terms of self-reported attitudes, distribution of rewards, helping an out-group confederate, and evaluation of an out-group candidate in a simulated hiring decision. In all experiments, perceived variability decreased prejudice and discrimination. This effect may be due to the fact that perceived variability decreases the role of group membership in the production of attitudes and behaviors toward other individuals.     

Switching in the cocktail party: exploring intentional control of auditory selective attention

Using a novel variant of dichotic selective listening, we examined the control of auditory selective attention. In our task, subjects had to respond selectively to one of two simultaneously presented auditory stimuli (number words), always spoken by a female and a male speaker, by performing a numerical size categorization. The gender of the task-relevant speaker could change, as indicated by a visual cue prior to auditory stimulus onset. Three experiments show clear performance costs with instructed attention switches. Experiment 2 varied the cuing interval to examine advance preparation for an attention switch. Experiment 3 additionally isolated auditory switch costs from visual cue priming by using two cues for each gender, so that gender repetition could be indicated by a changed cue. Experiment 2 showed that switch costs decreased with prolonged cuing intervals, but Experiment 3 revealed that preparation did not affect auditory switch costs but only visual cue priming. Moreover, incongruent numerical categories in competing auditory stimuli produced interference and substantially increased error rates, suggesting continued processing of task-relevant information that often leads to responding to the incorrect auditory source. Together, the data show clear limitations in advance preparation of auditory attention switches and suggest a considerable degree of inertia in intentional control of auditory selection criteria.     

Representational momentum in aviation

The purpose of this study was to examine the effects of expertise on motion anticipation. We conducted 2 experiments in which novices and expert pilots viewed simulated aircraft landing scenes. The scenes were interrupted by the display of a black screen and then started again after a forward or backward shift. The participant's task was to determine whether the moving scene had been shifted forward or backward. A forward misjudgment of the final position of the moving scene was interpreted as a representational momentum (RM) effect. Experiment 1 showed that an RM effect was detected only for experts. The lack of motion anticipation on the part of novices is a surprising result for the RM literature. It could be related to scene unfamiliarity, encoding time, or shift size. Experiment 2 was run with novices only. It was aimed at testing the potential impact of 2 factors on the RM effect: scene encoding time and shift size. As a whole, the results showed that encoding time and shift size are important factors in anticipation processes in realistic dynamic situations.     

Diagnosing fatigue in gait patterns by support vector machines and self-organizing maps

The aim of the study was to train and test support vector machines (SVM) and self-organizing maps (SOM) to correctly classify gait patterns before, during and after complete leg exhaustion by isokinetic leg exercises. Ground reaction forces were derived for 18 gait cycles on 9 adult participants. Immediately before the trials 7–12, participants were required to completely exhaust their calves with the aid of additional weights (44.4 ± 8.8 kg). Data were analyzed using: (a) the time courses directly and (b) only the deviations from each individual’s calculated average gait pattern. On an inter-individual level the person recognition of the gait patterns was 100% realizable. Fatigue recognition was also highly probable at 98.1%. Additionally, applied SOMs allowed an alternative visualization of the development of fatigue in the gait patterns over the progressive fatiguing exercise regimen.     

Motor execution affects action prediction

Previous studies provided evidence of the claim that the prediction of occluded action involves real-time simulation. We report two experiments that aimed to study how real-time simulation is affected by simultaneous action execution under conditions of full, partial or no overlap between observed and executed actions. This overlap was analysed by comparing the body sides and the movement kinematics involved in the observed and the executed action. While performing actions, participants observed point-light (PL) actions that were interrupted by an occluder, followed by a test pose. The task was to judge whether the test pose depicted a continuation of the occluded action in the same depth angle. Using a paradigm proposed by Graf et al., we independently manipulated the duration of the occluder and the temporal advance of the test pose relative to occlusion onset (occluder time and pose time, respectively). This paradigm allows the assessment of real-time simulation, based on prediction performance across different occluder time/pose time combinations (i.e., improved task performance with decreasing time distance between occluder time and pose time is taken to reflect real-time simulation). The PL actor could be perceived as from the front or back, as indicated by task instructions. In Experiment 1 (front view instructions), evidence of action simulation was obtained for partial overlap (i.e., observed and performed action corresponded either in body side or movement kinematics), but not for full or no overlap conditions. The same pattern was obtained in Experiment 2 (back view instructions), ruling out a spatial compatibility explanation for the real-time pattern observed. Our results suggest that motor processes affect action prediction and real-time simulation. The strength of their impact varies as a function of the overlap between observed and executed actions.