New evidence on the reliability and validity of the pediatric oncology quality of life scale

Abstract

The present paper replicates and extends previous studies on the psychometric properties of the Pediatric Oncology Quality of Life Scale (POQOLS). The research questions were focused on (a) internal consistency; (b) relation with demographics; and (c) ability to discriminate between patient groups. Data were gathered in a Dutch-speaking Belgian sample of 73 pediatric oncology patients, drawn from the population of a university hospital. The parents completed the POQOLS, a 21-item parent-report inventory for the assessment of physical restriction, emotional distress and discomfort from medical treatment in pediatric oncology patients. The results support the psychometric quality of the POQOLS. Three of the core aspects of quality of life are tapped using sufficiently short and internally consistent subscales. The instrument is free from relations with demographics and shows good discriminant ability to differentiate between patient groups according to time since diagnosis, treatment status and diagnosis.     

Understanding the impact of HIV diagnosis amongst gay men in Scotland: An interpretative phenomenological analysis

Objectives: Although a wide literature details the psychological impact of human immunodeficiency virus (HIV) diagnosis, it predates the introduction of effective treatment for HIV (i.e. anti-retroviral therapies, ARTs). This article explores the psychological impact of HIV diagnosis in post-ART accounts. This is important, given the recent policy developments which focus upon increasing HIV testing and thus diagnoses.

Design: This study presents a qualitative exploration of the experiential accounts of HIV-positive gay men living in Scotland. A total of 14 HIV-positive gay men took part in open-ended interviews.

Methods: Interpretative phenomenological analysis was employed to identify recurrent themes across the interviews.

Results: Our analysis focuses upon the participants’ struggles in adjusting to their HIV status. Diagnosis was a deeply shocking and unexpected experience. Stigma and fear of prejudice dominated their accounts. HIV was understood, variously, as a shameful, fatal and life-changing condition. Overall, within these accounts there was little sense of HIV normalisation.

Conclusions: In Scotland, where HIV prevalence is low, and where no accessible HIV-positive sub-culture exists, there is on-going psychological distress and morbidity amongst gay men testing HIV positive. As HIV-related policy increasingly focuses on increasing rates of antibody testing, there is a need to reduce the psychosocial costs associated with HIV-positive diagnoses.     

Demographic,health-related and psychosocial predictors of changes in depressive symptoms and anxiety in late middle-aged and older persons with fall-related injuries

Research on anxiety and depression after fall-related injuries to the extremities and its pre-fall determinants is scarce. The present study sought to examine change between pre-fall and post-fall anxiety and depression and its (pre-fall) predictors. Data were obtained from 181 Dutch persons, aged 57 and older, who sustained fall-related injuries between 1993 and 1997. Demographic (e.g. socio-economic status), health-related (e.g. number of chronic conditions), and psychosocial (e.g. social support, neuroticism) factors were determined in 1993 (prior to the fall). Depressive symptoms and anxiety were determined prior to the fall, and two, five and twelve months after the fall. Taking into account pre-fall anxiety and depression, pre-fall neuroticism was the most consistent, independent predictor of adverse changes in anxiety and depression. Other factors, including severity of the fall and age were not related to changes in anxiety and depression. Our prospective findings may be interpreted as support for the importance of personality for mental health outcomes in persons who have sustained fall-related injuries.     

Interference control in adolescents with Mild-to-Borderline Intellectual Disabilities and/or behavior disorders

The aim of this study was to investigate interference control in adolescents with Mild to Borderline Intellectual Disability (MBID) by addressing two key questions. First, as MBID is often associated with comorbid behavior disorders (BD), we investigated whether MBID and BD both affect interference control. Second, we studied whether interference control deficits are associated to problems in everyday executive functioning. Four groups of adolescents with and without MBID and/or BD performed the Eriksen flanker task, requiring participants to respond to a central target while ignoring interfering flanking stimuli. Their teachers rated behavior on the Behavior Rating Inventory Executive Function (BRIEF). We found pronounced effects of MBID but not BD on flanker interference control. In contrast, we observed pronounced effects of BD, but not MBID, on the BRIEF. In addition, flanker interference scores and BRIEF scores did not correlate. These results are taken to suggest that adolescents with MBID are characterized by deficits in interference control that do not become manifest in ratings of everyday executive functioning. In contrast, adolescents with BD are not characterized by deficits in interference control but do show elevated ratings of deficits in everyday executive function.     

Concurrent and 2-Year Longitudinal Relations Between Executive Function and the Behavior of 1st and 2nd Grade Children

Concurrent and 2-year longitudinal relations were investigated between two indicators of children’s (n =60; mean age = years 11 months) executive function, inhibitory control and sequencing ability, and behavior problem symptomatology. Dependent measures were parent and teacher reported internalizing and externalizing behavior. Hierarchical multiple regression analyses demonstrated few significant concurrent associations between either inhibitory control or sequencing ability, and behavior problem symptoms. In contrast, baseline inhibitory control predicted decreased teacher reported externalizing, and parent reported externalizing and internalizing behavior problems over a 2-year period. Baseline sequencing ability also predicted decreased teacher reported externalizing and parent reported internalizing behavior over this same time period. Results suggest that some aspects of executive function in early elementary grade-school children may be more strongly associated with change in behavior over time than concurrent behavior. Implications of these findings for the prevention of behavior problems are discussed.     

Validity of the Rey Visual Design Learning Test in Primary and Secondary School Children

Studies on adults have revealed a disadvantageous effect of negative emotional stimuli on executive functions (EF), and it is suggested that this effect is amplified in children. The present study’s aim was to assess how emotional facial expressions affected working memory in 9- to 12-year-olds, using a working memory task with emotional facial expressions as stimuli. Additionally, we explored how degree of internalizing and externalizing symptoms in typically developing children was related to performance on the same task. Before employing the working memory task with emotional facial expressions as stimuli, an independent sample of 9- to 12-year-olds was asked to recognize the facial expressions intended to serve as stimuli for the working memory task and to rate the facial expressions on the degree to which the emotion was expressed and for arousal to obtain a baseline for how children during this age recognize and react to facial expressions. The first study revealed that children rated the facial expressions with similar intensity and arousal across age. When employing the working memory task with facial expressions, results revealed that negatively valenced expressions impaired working memory more than neutral and positively valenced expressions. The ability to successfully complete the working memory task increased between 9 to 12 years of age. Children’s total problems were associated with poorer performance on the working memory task with facial expressions. Results on the effect of emotion on working memory are discussed in light of recent models and empirical findings on how emotional information might interact and interfere with cognitive processes such as working memory.     

The Contribution of Executive Skills to Reading Comprehension

Although word recognition deficits (WRD) are a known cause of reading comprehension deficits (RCD), other contributions to RCD, including executive function (EF), have not been fully explored. We examined the contribution of EF (working memory and planning), along with attention, decoding, fluency, and vocabulary to reading comprehension in 60 children (including 16 WRD and 10 RCD), ages 9–15 years. After controlling for commonly accepted contributors to reading comprehension (i.e., attention, decoding skills, fluency, and vocabulary), EF continued to make a significant contribution to reading comprehension but not to word recognition skills. These findings highlight the need for consideration of the role of EF in RCD.     

Manifestation of incommensurate structural modulations in the Ti- L 2,3 electron energy-loss near-edge structure of Sr2TiSi2O8

Structural modulations hosted by complex oxides are–beyond relative orientation changes of ‘rigid units’–accompanied by characteristic distortions of coordination polyhedra. Electronic structure calculations in the local density approximation, performed at model clusters derived from positionally modulated structures, proved that the molecular–orbital structure also sensitively reflects such distortions. The latter crystal-field splitting of unoccupied states is accessible by high-resolution electron energy-loss near-edge structure (ELNES) spectroscopy. However, since ELNES spectra average over many different individual target-ion environments, the resulting ELNES possesses significantly broadened spectral features. In this contribution, such broadening is shown to dramatically influence the spectral shape of the Ti-L _2,3 ELNES acquired at the strongly modulated fresnoite framework compound Sr₂TiSi₂O₈.     

Z-contrast imaging of the arrangement of Cu in precipitates in 6XXX-series aluminium alloys

High-resolution annular dark field imaging has been used to study small precipitates in the Al matrix of 6XXX-series aluminium alloys. Cu-containing columns in precipitates were imaged by atomic number contrast along a 〈100〉 matrix direction. At an under-aged condition, large, lath-shaped particles of the Cu-containing Q′-phase were observed at grain boundaries. At over-aged conditions, Q′ was the main matrix phase. In both cases the laths showed an Al {150} habit plane. A precursor phase was found, with different arrangement of Cu-rich columns from that of the Q′-phase and sharing Al {100} habit planes. Precipitates containing elements of both the Q′-phase and the precursor were found to be common. Annular dark field imaging can differentiate directly between phases. The method complements and aids interpretation of conventional high-resolution TEM images and nano beam diffraction observations. The results obtained contribute to an improved understanding of the crystallography of the precursor and details of the structural transformation taking place during the precipitation process.     

Compositions of different phases appearing during devitrification of Zr46.75Ti8.25Cu7.5Ni10Be27.5 bulk metallic glass

The devitrification process of Zr_46.75Ti_8.25Cu_7.5Ni₁₀Be_27.5 metallic glass during annealing in the supercooled liquid region has been studied by conventional, high-resolution and analytical transmission electron microscopy (TEM). Two kinds of particle appear during devitrification: quasicrystals and crystalline precipitates. Nanoanalysis with energy-dispersive X-ray spectroscopy and electron energy-loss spectroscopy reveal that quasicrystals are Be free, while the crystallites have the ZrBe₂ hexagonal structure. These experiments confirm the key role of Be during devitrification. They also indicate that quasicrystals can form in the system Zr–Ti–Cu–Ni (without Be), as further evidenced by direct synthesis and an in situ neutron diffraction investigation, according to the chemical composition deduced from the TEM analysis.