Application of chaos theory to biology and medicine

The application of “chaos theory” to the physical and chemical sciences has resolved some long-standing problems, such as how to calculate a turbulent event in fluid dynamics or how to quantify the pathway of a molecule during Brownian motion. Biology and medicine also have unresolved problems, such as how to predict the occurrence of lethal arrhythmias or epileptic seizures. The quantification of a chaotic system, such as the nervous system, can occur by calculating the correlation dimension (D2) of a sample of the data that the system generates. For biological systems, the point correlation dimension (PD2) has an advantage in that it does not presume stationarity of the data, as the D2 algorithm must, and thus can track the transient non-stationarities that occur when the systems changes state. Such non-stationarities arise during normal functioning (e.g., during an event-related potential) or in pathology (e.g., in epilepsy or cardiac arrhythmogenesis). When stochastic analyses, such as the standard deviation or power spectrum, are performed on the same data they often have a reduced sensitivity and specifity compared to the dimensional measures. For example, a reduced standard deviation of heartbeat intervals can predict increased mortality in a group of cardiac subjects, each of which has a reduced standard deviation, but it cannot specify which individuals will or will not manifest lethal arrhythmogenesis; in contrast, the PD2 of the very same data can specify which patients will manifest sudden death. The explanation for the greater sensitivity and specificity of the dimensional measures is that they aredeterministic, and thus are moreaccurate in quantifying the time-series. This accuracy appears to be significant in detecting pathology in biological systems, and thus the use of deterministic measures may lead to breakthroughs in the diagnosis and treatment of some medical disorders.     

Neighborhood frequency effects and letter visibility in visual word recognition

Two experiments are described that measured lexical decision latencies and errors to five-letter French words with a single higher frequency orthographic neighbor and control words with no higher frequency neighbors. The higher frequency neighbor differed from the stimulus word by either the second letter (e.g.,astre-autre) or the fourth letter (chope-chose). Neighborhood frequency effects were found to interact with this factor, and significant interference was observed only tochope-type words. The effects of neighborhood frequency were also found to interact with the position of initial fixation in the stimulus word (either the second letter or the fourth letter). Interference was greatly reduced when the initial fixation was on the critical disambiguating letter (i.e., the letterp inchope). Moreover, word recognition was improved when subjects initially fixated the second letter relative to when they initially fixated the fourth letter of a five-letter word, but this second-letter advantage practically disappeared when the stimulus differed from a more frequent word by its fourth letter. The results are interpreted in terms of the interaction between visual and lexical factors in visual word recognition.     

On axiomatization of many-valued logics associated with formalization of plausible reasonings

This paper studies a class of infinite-valued predicate logics. A sufficient condition for axiomatizability of logics from that class is given.To the memory of Jerzy Supecki     

Context effects in stroop-like word and picture processing

Presents a series of 6 experiments in which Stroop-like effects were generated by modally pure color-color, picture-picture, and word-word stimuli instead of the usual modally mixed color-word or picture-word stimuli. Naming, reading, and categorization tasks were applied. The Stroop inhibition was preserved with these stimuli but unexpectedly showed a semantic gradient only in the naming and not in the reading task. Word categorizing was slower and more interference prone than picture categorizing. These and other results can be captured by a model with two main assumptions: (a) semantic memory and the lexicon are separate, and (b) words have privileged access to the lexicon, whereas pictures and colors have privileged access to the semantic network. Such a model is developed and put to an initial test.     

Spatial frequencies and the cerebral hemispheres: contrast sensitivity, visible persistence, and letter classification

The hypothesis that the two cerebral hemispheres are specialized for processing different visual spatial frequencies was investigated in three experiments. No differences between the left and right visual fields were found for: (1) contrast-sensitivity functions measured binocularly with vertical gratings ranging from 0.5 to 12 cycles per degree (cpd); (2) visible persistence durations for 1- and 10-cpd gratings measured with a stimulus alternation method; and (3) accuracy (d') and reaction times to correctly identify digitally filtered letters as targets (L or H) or nontargets (T or F). One significant difference, however, was found: In Experiment 3, a higher decision criterion (beta) was used when filtered letters were identified in the right visual field than when they were identified in the left. The letters were filtered with annular, 1-octave band-pass filters with center spatial frequencies of 1, 2, 4, 8, and 16 cpd. Combining four center frequencies with three letter sizes (0.5 degrees, 1 degree, and 2 degrees high) made some stimuli equivalent in distal spatial frequency (cycles per object) and some equivalent in proximal spatial frequency (cycles per degree). The effective stimulus in the third experiment seemed to be proximal spatial frequency (cycles per degree) not distal (cycles per object). We conclude that each cerebral hemisphere processes visual spatial frequency information with equal accuracy but that different decision rules are used.     

Attention deficit disorder with hyperactivity and methylphenidate: The effects of dose and mastery level on children's learning performance

This investigation examined the relationship between methylphenidate (MPH) and the learning and recall of paired associations by children with attention deficit disorder with hyperactivity (ADDH). Forty-five children with ADDH were randomly assigned to one of three groups (novel, partial mastery, and mastery learning) that varied in the amount of previous learning of paired associations and participated in a double-blind, placebo-control, repeated-measures-across-dose (crossover) design. Each child received four doses of MPH (5 mg, 10 mg, 15 mg, and 20 mg) and a placebo in a random, counterbalanced sequence. The results indicated that both the rate of acquisition and accuracy in learning paired associations were significantly, but differentially, affected by MPH dose and the degree of learning mastery. The implications of these results for psychopharmacological research and the monitoring of psychostimulant effects on children's learning performance in academic settings are discussed.The authors wish to acknowledge and express their sincere appreciation to the graduate and undergraduate student members of the Children's Learning Clinic.     

Are words represented by nodes?

Semantic priming in a lexical decision task was investigated with concurrent pretarget and posttarget primes. The posttarget prime also served as a pattern mask of the lexical decision target. Forward priming is defined as the presence of a semantically related pretarget prime and an unrelated posttarget prime. Backward priming is defined as the presence of a semantically related posttarget prime and an unrelated pretarget prime. Forward and backward priming were compared both when the nonword foils were "legal" and when they were "illegal" with respect to English orthography. Predictions were derived for two general approaches to word recognition: spreading-activation and expectancy-set theories. Both approaches assume that word representations occupy distinct, nonoverlapping locations in memory. Backward-prime facilitation was equivalent to forward-prime facilitation when nonword foils were illegal; however, backward-prime facilitation was not significant when nonword foils were legal. These results challenge both approaches. The proposed solution uses semantic-space (distributed) representations that are functionally unitized by a resonant matching (verification) process.     

Altering memory through recall: The effects of cue-guided retrieval processing

Three experiments were designed to investigate the influence of initial recall on memory by assessing delayed recall after different immediate cued-recall tests. In all experiments, subjects performed semantic and phonemic encoding tasks on a word list. The subjects then received a cued-recall test that cued the target using the same word as the context word in the encoding task, a test that cued the target with a word from the same level at which the target was encoded, a test that cued the target with a cue from a different level at which the target was encoded, or no immediate-recall test. One day later, the subjects performed a final cued-recall test in which the type of cue (semantic or phonemic) was varied. Consistently, delayed recall was facilitated primarily when the cue on the immediate test was from the same level as the cue on the delayed test. This pattern of facilitation suggests that immediate cued-recall produces an elaboration of an existing memory representation that is closely tied to the type of cue used on the immediate test.     

Using item-specific instructional information in achievement modeling

The problem of detecting instructional sensitivity (item basis) in test items is considered. An illustration is given which shows that for tests with many biased items, traditional item bias detection schemes give a very poor assessment of bias. A new method is proposed instead. This method extends item response theory (IRT) by including item-specific auxiliary measurement information related to opportunity-to-learn. Item-specific variation in measurement relations across students with varying opportunity-to-learn is allowed for.This paper was presented at the 1987 AERA meeting in Washington, DC. This research was supported by grant OERI-G-86-003 from the Office of Educational Research and Improvement, Department of Education. The author thanks Michael Hollis and Chih-fen Kao for valuable research assistance, and appreciates valuable comments made by an anonymous reviewer.     

Teaching self-treatment of cold symptoms to an anoxic brain injured adult

Traumatic brain injury can result in behavioral and physical deficits that require intensive post-acute residential rehabilitation. Behaviors targeted by such programs include basic self-care and living skills. We examined the efficacy of a behavioral training strategy to teach appropriate medical treatment of four different groups of simulated cold symptoms to an anoxic brain injured adult. The strategy included instructor prompting and feedback in the use of written task analyses and picture cues as self-administered prompts. Subsequent to baseline, the participant used written generic task analyses combined with picture cues and then, if necessary, written specific task analyses combined with picture cues to prompt appropriate self-treatment of the four types of colds. Written individualized task analyses, tailored to participant errors, were used to fade specific task analysis prompts and transfer stimulus control to the discriminative stimuli present in the picture cues. A multiple baseline design across responses showed that skill acquisition did not occur after generic task analysis training, but did so after specific task analysis training. The participant responded to all four types of colds for three consecutive trials at 100% correct under baseline conditions. Follow-up results indicated that transfer of stimulus control to the cold symptoms simulated by the picture cues alone did not maintain over time. Correct responding was retrained using generic and, if necessary, individualized task analysis training conditions.