Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory

Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP3-PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that IP3 receptor (IP3R)-evoked calcium release results in SK channel-dependent hyperpolarization of prefrontal neurons. However, the effects of IP3R signaling on prefrontal function have not been investigated. The present findings demonstrate that blockade of IP3R or SK channels in the prefrontal cortex enhances WM performance in rats, suggesting that both arms of the PI cascade influence prefrontal cognitive function.     

Academic Integrity from China to the United States: The Acculturation Process for Chinese Graduate Students in the United States

The ethics-related beliefs of Chinese international graduate students are heavily influenced by their academic cultural background, and given the nature of that culture, they often face challenges when adapting to the U.S. academic environment. This qualitative study examines Chinese graduate students’ perceptions of the differences between Chinese and American academic integrity practices and the effects of those differences on their ethical practices and adaptations in a graduate program in the United States. Data were collected via semistructured interviews in a public university in the United States. Findings suggest that perceptions of academic integrity in Chinese universities are influenced by Confucian philosophy, collectivist assumptions, and a resultant convenience mind-set. These cultural premises clash with academic expectations in the United States. Participants describe how they, and their Chinese peers, navigate U.S. integrity standards and provide recommendations for ways that U.S. schools can help them better adjust. We expand on those and provide recommendations for university personnel.     

It Is Time to Observe the Creative Process: How to Use a Creative Process Report Diary (CRD)

Although the first research on the creative process was based on interviews with the aim of identifying the main stages (macro‐process), in the last 50 years researchers have focused more on the analysis of micro‐processes, i.e., the mechanisms underlying the generation of ideas. This interest in the micro‐processes is partly a result of the tools available to researchers to carry out rigorous studies on the creative process. In this article, we present a useful and relevant analytical tool for macro‐processes to assess the creative process in a natural context and when it occurs. Here, the reader will find advice on establishing a research protocol for the creative process by using diaries. Examples of diaries and results are presented. The advantage of this tool is that it enables a direct, rich, and inexpensive assessment of the creative process. Thus, the ecological validity of the diary method is particularly high.     

Improving Service Evaluation in Clinical Genetics: Identifying Effects of Genetic Diseases on Individuals and Families

Outcome measurement in clinical genetics is challenging. Outcome attributes used currently have been developed by service providers or adapted from measures used in other areas of healthcare. Many of the ‘patients’ in clinical genetics are healthy but at risk of developing or transmitting a condition. Usually no pharmacological or surgical treatment is offered, although information-giving is an objective of most consultations. We argue that services should be evaluated on the basis of how well they alleviate the effects of disease, from a patient perspective. This paper describes a qualitative study using seven focus groups with health professionals, patients and patient representatives. Social and emotional effects of genetics diseases were identified. Some differences emerged between the effects identified by health professionals and those identified by patients. These findings will be used to inform the evaluation of existing outcome measures and develop robust measures of outcome for clinical genetics services.     

Licensure of Internationally Educated Nurses Seeking Professional Careers in the Province of Alberta in Canada

While the regulation of nursing practice through licensure ensures that nurses meet minimum standards for safe competent and ethical care, it also inhibits integration of immigrant internationally educated nurses (IENs) into the Canadian professional labour market. With projections of significant nurse workforce shortages by 2010, there is impetus to enhance the numbers of licensed professional nurses through multiple strategies. The licensure processes and accompanying tensions in the Canadian context are described. As professional nurse licensure in Canada is a provincial responsibility, the situation in the Province of Alberta is used as an example. Suggestions for policy development and research include needs for better data and for gender-based analysis to address barriers to IEN licensure. The ability to practice in one’s chosen profession can be a major factor in integration of immigrants into Canadian society and thus a powerful factor in attraction and retention of highly skilled immigrants.     

Cognitive and emotional control and perspective taking and their relations to empathy in 5-year-old children

The experience of empathy has been described as involving both emotional and cognitive components. The primary hypothesis tested in this study is that cognition and emotion are integrated within 2 distinct types of abilities-control and perspective taking-and that interactions between emotional and cognitive control and between affective and cognitive perspective taking would be related to children's empathic responding. We also hypothesized that boys' control and perspective-taking skills would be more strongly related to empathy than would those of girls. Fifty-seven 5-year-olds completed tasks measuring cognitive control, cognitive and affective perspective taking, and empathy, and their mothers completed a measure of children's emotional control. Results indicated that cognitive perspective taking moderated the relation between affective perspective taking and empathy. In addition, the relation between cognitive inhibitory control and empathy was moderated by gender; boys' control was positively related to empathy, but girls' control was marginally negatively related to empathy.     

Differences in risk factors for suicidality between African American and White patients vulnerable to suicide

Risk factors for suicidal ideation and attempts have been shown to differ between African Americans and Whites across the lifespan. In the present study, risk factors for suicidality were examined separately by race/ethnicity in a population of 131 older adult patients considered vulnerable to suicide due to substance abuse and/or medical frailty. In adjusted analyses, social support was significantly associated with suicidality in African American patients, while younger age and the presence of an anxiety disorder were significantly associated with suicidality in White patients. The results suggest that race/ethnicity-specific risk profiles may improve the detection of suicidality in vulnerable populations.     

Do Extenuating Circumstances Influence African American Women's Attitudes Toward Suicide?

African American women commit suicide less than other U.S. women and men, perhaps partly due to strong, anti-suicide attitudes. To see if suicide attitudes might be softened by extenuating circumstances such as terminal illness, 192 African American and European American women imagined themselves in one of four extenuating circumstances, then completed measures of suicide acceptability and religiosity. Both ethnic groups reported a greater likelihood of suicide when imagining depression, regardless of religiosity. Religiosity, but not extenuating circumstances, corresponded with negative attitudes toward suicide and physician assisted suicide. These African American and European American young women remained steadfastly against suicide, regardless of circumstance.