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221.
African Americans are disproportionately affected by the HIV epidemic inclusive of men who have sex with men, heterosexual men, and women. As part of a community‐based participatory research study we assessed HIV testing experience among sexually active 18–30 year old Black men and women in Durham, NC. Of 508 participants, 173 (74 %) men and 236 (86 %; p = 0.0008) women reported ever being tested. Barriers to testing (e.g., perceived risk and stigma) were the same for men and women, but men fell behind mainly because a primary facilitator of testing—routine screening in clinical settings—was more effective at reaching women. Structural and behavioral risk factors associated with HIV infection were prevalent but did not predict HIV testing experience. Reduced access to health care services for low income Black young adults may exacerbate HIV testing barriers that already exist for men and undermine previous success rates in reaching women.  相似文献   
222.
Two studies investigate the psychological processes underlying short- and long-term effects of video game violence on interpersonal trust. Study 1 demonstrates that interacting with physically aggressive virtual agents decreases players' trust in subsequent interactions. This effect was stronger for players who were dispositionally sensitive to victimization. In Study 2, long-term effects of adolescents' frequent exposure to video game violence on interpersonal trust and victim sensitivity were investigated. Cross-lagged path analyses show that the reported frequency of playing violent video games reduced interpersonal trust over a period of 12 months, particularly among victim-sensitive players. These findings are in line with the sensitivity to mean intentions (SeMI) model, and they suggest that interpersonal mistrust is a relevant long-term outcome of frequent exposure to video game violence.  相似文献   
223.
In the present research the interaction between the endogenous ligand for the cannabinoid CB1 receptor anandamide (arachidonylethanolamide) and morphine in memory consolidation was investigated. Four sets of experiments were carried out with CD1 mice tested in a one-trial inhibitory avoidance task. The drugs were administered intraperitoneally after training of the animals in the apparatus. In the first set of experiments morphine (0.3 or 0.5, but not 0.15mg/kg) or anandamide (3 or 6 but not 1.5mg/kg) dose-dependently impaired memory consolidation. In the second set of experiments the administration of an otherwise ineffective dose of anandamide (1.5mg/kg) enhanced the memory impairment exerted by morphine (0.3 and 0.5mg/kg) when the drugs were injected immediately after training. In the third set of experiments the combined treatments of anandamide (1.5mg/kg) and morphine (0.5mg/kg) 2h after training were ineffective showing that the effects observed on performance following immediate posttraining administration of anandamide and morphine combinations were reflecting direct influences on memory consolidation. In the fourth set of experiments otherwise ineffective doses of the D1 DA receptor agonist SKF 38393 or the D2 DA receptor agonist LY 171555 antagonized the memory impairment produced by anandamide and morphine in combination, suggesting a possible involvement of dopaminergic mechanisms.  相似文献   
224.
Abstract

Four experiments assessed similarities and differences in learned helplessness and depression-related deficits in cognitive performance and self-focused cognitions. Subjects answered the Beck Depression Inventory (Beck, Ward, Mendelson, Mock, & Erbaugh, 1961), were exposed to no-feedback or failure in unsolvable problems, and their response time in a digit comparison task (with or without a memory component, with different number of digits, and different number of mental transformations) and self-focused cognitions were assessed. Learned helplessness and depression deficits were found in a memory task, and the deficits increased with the number of digits. Depression deficits also increased with the number of transformations, and were also found in the no-memory/two transformation condition. Finally, task-related worries were related to learned helplessness deficits, and task-irrelevant thoughts were related to depression deficits. Findings were discussed in terms of the cognitive specificity of learned helplessness and depression deficits.  相似文献   
225.
This study examined the contribution of illness severity and attachment style to marital satisfaction among mothers of infants with Congenital Heart Disease (CHD) as well as the mediating role of cognitive appraisal and ways of coping with motherhood tasks. Eighty-five mothers of newborns with CHD rated their attachment style 2 weeks after the infant's CHD diagnosis and two physicians rated the severity of the disease. One year later, mothers completed self-reports scales tapping marital satisfaction, appraisal of motherhood tasks, and ways of coping with these tasks. The severity of infant's disease and mothers’ attachment anxiety and attachment avoidance were related to less marital satisfaction. Moreover, whereas illness severity and attachment anxiety had direct effects on marital satisfaction, the negative effects of attachment avoidance were mediated by the appraisal of motherhood in threatening terms and the reliance on emotion-focused coping. The interconnections between attachment style, the process of coping with the stress of a chronic illness, and marital satisfaction were discussed.  相似文献   
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Three levels of working memory load of a visual search (Memory and Search) task were tested in a 72-hour sleep deprivation paradigm. General performance and accuracy decrease over time with monotonic and rhythmic components. The signal detection discriminability index, d', decreases monotonically with rhythmic variations. The index of response bias, β, shows no monotonic trend, but significant circadian rhythmicity. The extent of the monotonic and rhythmic changes in accuracy and in d' is directly related to the level of working memory load. The amplitude of the circadian component of accuracy and d' is enhanced for the higher levels of working memory load. The implication of potentiated circadian rhythmicity as a function of cumulative sleep loss is discussed.  相似文献   
229.
This article describes the spectrum of recurrent thoughts and behaviors that can result from frontotemporal dementia (FTD) and its variants. Although repetitive behaviors can result from a range of brain disorders, FTD is the most common neurologic cause of new-onset recurrent thoughts and behaviors in middle or late life. Patients with FTD can manifest typical or bizarre compulsions, hoarding, verbal and motor stereotypies and complex tics; self-injurious acts, perseverations; and fixed, obsessional thoughts. The frequency and variability of these repetitive behaviors suggest a common disturbance of orbitofrontal-basal ganglia circuits involved in response inhibition. The amelioration of these recurrent events with the administration of serotonin selective reuptake inhibitors further suggests a serotonergic deficit.  相似文献   
230.
The Pavlovian analysis of drug tolerance describes how the contexts of drug administration participate in the elicitation of compensatory conditioned responses that are, at least partly, responsible for tolerance. Findings indicate that if an association is acquired in one context and extinguished in another one, when exposing the subjects to the acquisition context, renewal of the conditioned response will take place. Ambiguous evidence exists about whether or not this effect diminishes when extinguishing the association in multiple contexts. This investigation evaluates the existence of the phenomenon of renewal of tolerance to ethanol, and whether it diminishes by the extinction in multiple contexts. Evidence of renewal of tolerance to ethanol in rats was found, but no diminution was observed when extinguishing in multiple contexts.  相似文献   
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