Genes and memory: the neuroanatomical correlates of emotional memory in monozygotic twin discordant for schizophrenia

BACKGROUND: Brain morphology and physiological measures in schizophrenia have yielded inconsistent results. This may be due in part to difficulties in ascertaining precisely to what degree each measure deviates from its genetically and environmentally determined potential level. We attempted to surmount this problem in a paradigm involving monozygotic twin pair discordant for schizophrenia. In this paradigm, the difference score and reaction time between the unaffected member and affected member of a twin pair should represent the degree of pathologic involvement irrespective of actual level. METHOD: We investigated, using fMRI, the neural substrate underlying encoding and retrieval of aversive and neutral IAPS pictures. RESULTS: An ANOVA on reaction time (RT) between schizophrenia patient (J) and normal sister (D) significant difference, (F = 5.2, p < or = .02) for J had less RT than D. Conversely, the ANOVA for the correct pictures retrieved was insignificant (F = 1.8, p < or = .2). When the brain activity associated with the encoding and retrieval of the aversive pictures was subtracted (J-D and D-J) from that associated with the neutral ones, significant loci of activation were found. During encoding: for J-D the right fusiform gyrus was significantly activated (p < .0001) and for D-J the orbitofrontal cortex was significantly activated (p < .05). During retrieval: for J-D the right anterior cingulate (p < .0001) was activated and the dorsolateral prefrontal cortex (p < .002). For D-J only the cerebellum showed activation (p < .0001). CONCLUSION: Results indicated subtle attenuations in some aspects of memory, thus providing another evidence for cognitive markers of a genetic component in schizophrenia. New approaches in neuropsychiatry-based on genetic methodologies should further define the cerebral physiology responsible for schizophrenia.     

Index of Subjects

Subject Index

Index of Subjects     

Anandamide and memory in CD1 mice: effects of immobilization stress and of prior experience

Five sets of experiments were carried out with CD1 mice tested in a one-trial inhibitory avoidance task. In a first set, immediately posttraining administrations of the endogenous ligand for the cannabinoid CB1 receptor anandamide (arachidonylethanolamide) (3 or 6 mg/kg) dose-dependently impaired memory consolidation in mice. A lower dose (1.5 mg/kg) was ineffective. In a second set of experiments, which was carried out at the same time of the first set, preexposure of the animals to the testing apparatus decreased the effect of the drug, as compared with non-preexposed mice. In a third set of experiments, administration of anandamide (3 or 6 mg/kg) prior to the retention test did not affect the retention performance of mice given posttraining injections of either saline or anandamide. These findings indicate that the memory-impairing effects of posttraining administration of anandamide are not state-dependent. In the fourth and fifth series of experiments, carried out with non-preexposed mice, an otherwise ineffective immobilization stress (15 min) enhanced the memory-impairing effect of anandamide, and an otherwise ineffective dose of naltrexone (0.1 mg/kg) completely antagonized the effect. The results are discussed in terms of attenuation of emotionality, resulting in impaired retention, following anandamide administration, and of involvement of opioid system in the effect of this drug.     

Evidence for a double dissociation between spatial-simultaneous and spatial-sequential working memory in visuospatial (nonverbal) learning disabled children

The paper describes the performance of three children with specific visuospatial working memory (VSWM) impairments (Study 1) and three children with visuospatial (nonverbal) learning disabilities (Study 2) assessed with a battery of working memory (WM) tests and with a number of school achievement tasks. Overall, performance on WM tests provides evidence of a double dissociation between spatial-simultaneous processes, underpinning the memorization item positioning in a spatial configuration, and spatial-sequential processes, which allow memorization of the presentation order. In both groups of children of the two studies, a selective impairment either on spatial-sequential or on spatial-simultaneous working memory tasks was observed. These data support the existence of -simultaneous and -sequential modality-dependent processes in visuospatial working memory and confirm the importance of distinguishing between different subtypes of visuospatial (nonverbal) learning-disabled children.     

Frequency effects with visual words and syllables in a dyslexic reader

The present study investigated the nature of the inhibitory syllable frequency effect, recently reported for normal readers, in a German-speaking dyslexic patient. The reading impairment was characterized as a severe deficit in naming single letters or words in the presence of spared lexical processing of visual word forms. Three visual lexical decision experiments were conducted with the dyslexic patient, an unimpaired control person matched to the patient and a control group: Experiment 1 manipulated the frequency of words and word-initial syllables and demonstrated systematic effects of both factors in normal readers and in the dyslexic patient. The syllable frequency effect was replicated in a second experiment with a more strictly controlled stimulus set. Experiment 3 confirmed the patient's deficit in activating phonological forms from written words by demonstrating that a pseudohomophone effect as observed in the unimpaired control participants was absent in the dyslexic patient.     

Attachment style, excessive reassurance seeking, relationship processes, and depression

The authors examined the association between excessive reassurance seeking (ERS) in couple relationships and depression, hypothesizing that this association can be explained by attachment anxiety. In Study 1, 72 couples completed questionnaires about ERS, depression, attachment style, and relationship quality. In Study 2, 61 couples completed the same measures in addition to completing daily diary assessments for 14 days. In both studies, ERS was related to depression, but only because of its association with attachment anxiety. The association between attachment anxiety and depression was not mediated by either partner's relationship quality, even though partners noticed each other's ERS. Instead, relationship quality was related primarily to avoidant attachment. These findings were replicated at a daily level of analysis, where interesting details of the underlying processes were revealed. At least in young unmarried couples, depression is associated with attachment anxiety--and one of its facets, ERS--mostly for intrapsychic reasons.     

Spontaneous Correction in the Behavioral Confirmation Process: The Role of Naturally-Occurring Variations in Self-Regulatory Resources

Perceivers' tendencies to correct for expectancy-related biases can be affected by experimental manipulations of goals and cognitive resources. In the current research, we examined the role of naturally-occurring, environmentally-produced variations in self-regulatory resources, represented by the time of semester in which college students participated. A pilot study established the association between time of semester and self-regulatory resources. Using a simulated job interview paradigm, interviewers were induced with extreme expectancies regarding their applicants. The effects of expectancy valence depended on time of semester. Interviewers with depleted self-regulatory resources (i.e., late-semester participants) asked expectancy-biased questions, elicited expectancy-confirming behavior from applicants, and formed expectancy-consistent impressions, while their less-depleted, early-semester counterparts did not. The findings suggest that interviewers engaged in spontaneous behavioral and perceptual correction for the biasing influence of extreme expectancies, but only when sufficient self-regulatory resources were available. The discussion focuses on theoretical implications for models of bias correction and applied significance.     

The effects of implicit and explicit security priming on creative problem solving

Attachment theory is a theory of affect regulation as it occurs in the context of close relationships. Early research focused on regulation of emotions through maintenance of proximity to supportive others (attachment figures) in times of need. Recently, emphasis has shifted to the regulation of emotion, and the benefits of such regulation for exploration and learning, via the activation of mental representations of attachment figures (security priming). We conducted two studies on the effects of implicit and explicit security priming on creative problem solving. In Study 1, implicit security priming (subliminal presentation of attachment figures’ names) led to more creative problem solving (compared with control conditions) regardless of dispositional attachment anxiety and avoidance. In Study 2, the effects of explicit security priming (recalling experiences of being well cared for) were moderated by anxiety and avoidance. We discuss the link between attachment and exploration and the different effects of implicit and explicit security priming.     

Marital intimacy,family support,and secondary traumatization: A study of wives of veterans with combat stress reaction

Abstract

The main aim of the study was to assess the role of family variables in the process of secondary traumatization among wives of post-traumatic veterans. We compared a sample of 49 wives of Israeli veterans with combat stress reaction (CSR) from the 1982 Lebanon War with a sample of 31 wives of Israeli veterans who fought in the war without developing CSR. We assessed their psychological reactions to the war, their health status six years later, and their reported levels of marital intimacy and family support after the war. When compared with controls, wives of veterans with CSR reported more negative emotions and lower perceived intimacy after the war, and greater severity of psychiatric and somatic symptoms six years later. Results also indicate that the greater the perceived marital intimacy, the less the negative emotions wives of veterans with CSR felt after the war and the better their health status six years later. In addition, wives of veterans with CSR who reported having received more support from their families after the war reported more anxiety and hostility than wives who received less support. The roles of marital intimacy and family support in the process of secondary traumatization were discussed.