Neuropsychological and Behavioral Effects of Antiepilepsy Drugs

Antiepilepsy drugs work by decreasing neuronal irritability, which may also result in the non-desired side effect of decreased neuropsychological function. In addition to cognitive side effects, antiepilepsy drugs (AEDs) may be associated with behavioral effects which may range from irritability and hyperactivity to positive psychotropic effects on mood. There have been many new medications released since the 1990s, and although they tend to have more favorable side effect profiles compared to their older counterparts, there continues to be a risk of decreased cognitive function with the majority of these agents. The effects of in utero antiepilepsy drug exposure are increasingly being investigated, and differential drug risk is beginning to be described for both anatomic and cognitive outcomes. Patients with epilepsy undergoing neuropsychological evaluations are commonly on AEDs, and it is important for the clinician to recognize the potential contribution of AED therapy to neuropsychological profiles. The present article serves to provide an overview of our current understanding regarding the risks of antiepilepsy drug use for both cognitive and behavioral side effects.     

The role of closure in defining the “objects” of object-based attention

Many recent studies have concluded that the underlying units of visual attention are often discrete objects whose boundaries constrain the allocation of attention. However, relatively few studies have explored the particular stimulus cues that determine what counts as an “object” of attention. We explore this issue in the context of the two-rectangles stimuli previously used by many investigators. We first show, using both spatial-cuing and divided-attention paradigms, that same-object advantages occur even when the ends of the two rectangles are not drawn. This is consistent with previous reports that have emphasized the importance of individual contours in guiding attention, and our study shows that such effects can occur in displays that also contain grouping cues. In our divided-attention experiment, however, this contour-driven same-object advantage was significantly weaker than that obtained with the standard stimulus, with the added cue of closure—demonstrating that contour-based processes are not the whole story. These results confirm and extend the observation that same-object advantages can be observed even without full-fledged objects. At the same time, however, these studies show that boundary closure—one of the most important cues to objecthood per se—can directly influence attention. We conclude that object-based attention is not an all-or-nothing phenomenon; object-based effects can be independently strengthened or weakened by multiple cues to objecthood.     

Thought-action fusion: a comprehensive analysis using structural equation modeling

Thought-action fusion (TAF), the phenomenon whereby one has difficulty separating cognitions from corresponding behaviors, has implications in a wide variety of disturbances, including eating disorders, obsessive-compulsive disorder, generalized anxiety disorder, and panic disorder. Numerous constructs believed to contribute to the etiology or maintenance of TAF have been identified in the literature, but to date, no study has empirically integrated these findings into a comprehensive model. In this study, we examined simultaneously an array of variables thought to be related to TAF, and subsequently developed a model that elucidates the role of those variables that seem most involved in this phenomenon using a structural equation modeling approach. Results indicated that religiosity, as predicted by ethnic identity, was a significant predictor of TAF. Additionally, the relation between ethnic identity and TAF was partially mediated by an inflated sense of responsibility. Both TAF and obsessive-compulsive symptoms were found to be significant predictors of engagement in neutralization activities. Clinical and theoretical implications are discussed.     

Hyperreflexivity as a condition of mental disorder: a clinical and historical perspective

Hyperreflexivity, understood as intensified self-consciousness in which subjects disengage from normal forms of involvement with nature and society, often considering themselves as objects of focal awareness, is proposed here as a condition of mental disorders, without which they would not exist. This thesis is argued from a dual perspective: clinical and historical. In the clinical perspective, it is shown that hyperreflexivity is not merely concomitant with mental disorders, but indeed has causal priority over them. Empirical evidence of a correlational, experimental and therapeutic nature, or deriving from cultural change, supports this claim of causal priority. In the historical perspective, it is shown that hyperreflexivity depends on certain historical-cultural circumstances that have prevailed since the Renaissance. These circumstances have to do with the emergence of the modern subject, displaced, autonomous and condemned to a hapless 'interior journey'. This means that mental disorders as such would not have existed prior to that era. Nor in the wake of the Renaissance would mental disorders automatically come into being, depending as they do on a reflexive, institutional clinical context, which would not emerge until practically the nineteenth century, but which would extend swiftly from then on.     

Post Traumatic Stress,Context, and the Lingering Effects of the Hurricane Katrina Disaster among Ethnic Minority Youth

This study examined the stability of post traumatic stress disorder (PTSD) symptoms in a predominantly ethnic minority sample of youth exposed to Hurricane Katrina. Youth (n = 191 grades 4th thru 8th) were screened for exposure to traumatic experiences and PTSD symptoms at 24 months (Time 1) and then again at 30 months (Time 2) post-disaster. PTSD symptoms did not significantly decline over time and were higher than rates reported at earlier time points for more ethnically diverse samples. Younger age, female sex, and continued disrepair to the child’s home predicted stable elevated PTSD symptoms. Findings are consistent with predictions from contextual theories of disaster exposure and with epidemiological data from adult samples suggesting that the incidence of PTSD post Katrina is showing an atypical pattern of remittance. Theoretical, applied, and policy implications are discussed.     

Cognitive mediators in the reduction of pain: the role of expectancy, strategy use, and self-presentation

Eighty subjects underwent three trials of cold-pressor pain. The first cold-pressor trial served as a baseline. Next, subjects in a neutral (no expectancy information) condition were taught a distraction strategy (shadowing letters) before one cold-pressor trial and an imagery strategy before the other. Subjects in other conditions received positive expectancy information about one of the strategies and negative expectancy information about the other. Negative information reduced expectancy ratings and decreased the magnitude of reported pain reductions. Both pretested levels of social desirability and degree of absorption in strategy use made contributions to the prediction of pain reduction that were independent of expectancy ratings. Theoretical implications are discussed.     

Encoding Modal Logics in Logical Frameworks

We present and discuss various formalizations of Modal Logics in Logical Frameworks based on Type Theories. We consider both Hilbert- and Natural Deduction-style proof systems for representing both truth (local) and validity (global) consequence relations for various Modal Logics. We introduce several techniques for encoding the structural peculiarities of necessitation rules, in the typed -calculus metalanguage of the Logical Frameworks. These formalizations yield readily proof-editors for Modal Logics when implemented in Proof Development Environments, such as Coq or LEGO.     

A preliminary investigation of the construct of psychopathic personality (psychopathy) in chimpanzees (Pan troglodytes)

Although the construct of psychopathy has received considerable attention in humans, its relevance to other animals is largely unknown. We developed a measure of psychopathy for use in chimpanzees (Pan troglodytes), the Chimpanzee Psychopathy Measure (CPM), and asked 6 raters to complete this index on 34 chimpanzees. The CPM (a) demonstrated satisfactory interrater reliability and internal consistency; (b) exhibited marginally significant sex differences (males > females); (c) correlated positively with measures of extraversion, agreeableness, and observational ratings of agonism, sexual activity, daring behaviors, teasing, silent bluff displays, and temper tantrums, and negatively with observational ratings of generosity; and (d) demonstrated incremental validity above and beyond a measure of dominance. Although further validation of the CPM is needed, these findings suggest that the psychopathy construct may be relevant to chimpanzees.     

Anchoring effects on early autobiographical memories

Studies of childhood memory typically show that our earliest memories come from between three and four years of age. This finding is not universal, however. The age estimate varies across cultures and is affected by social influences. Research from the judgments and decision-making literature suggests that these estimates might also involve a judgment under uncertainty. Therefore, they might be susceptible to less social influences such as heuristics and biases. To investigate this possibility, we conducted two experiments that used anchoring paradigms to influence participants’ estimates of their age during early autobiographical memories. In Experiment 1, participants answered either a high-anchor or a low-anchor question, and were warned that the anchor was uninformative; they went on to estimate their age during their earliest autobiographical memory. In Experiment 2, we replicated Experiment 1 and extended the design to examine additional early autobiographical memories. In both experiments, participants in the low-anchor condition gave earlier age estimates than those in the high-anchor condition. These results provide new insights into the methods used to investigate autobiographical memory. Moreover, they show that reports of early autobiographical memories can be influenced by a relatively light touch – a change to a single digit in a single question.     

ON ESSENTIALLY CONFLICTING DESIRES

It is sometimes argued that having inconsistent desires is irrational or otherwise bad for an agent. If so, if agents seem to want a and not-a, then either their attitudes are being misdescribed – what they really want is some aspect x of a and some aspect y of not-a – or those desires are somehow 'inconsistent' and thus inappropriate. I argue first that the proper characterization of inconsistency here does not involve logical form, that is, whether the desires involved have the form 'a and not-a', but rather the possibility of fulfilling all one's desires; and secondly, that the 'essential' conflicts involved in such inconsistencies are quite common and no worse for an agent than contingent conflicts. I draw implications concerning moral epistemology, moral realism and the logic of attitudes.