视觉形状知觉在近似数量系统和计算流畅性关系中的作用

已有大量研究揭示了近似数量系统与计算流畅性的相关关系, 但缺少对二者关系原因的系统检验与论证。视觉形状知觉假设有别于传统的数量领域特异性解释, 认为对形状的快速知觉是近似数量系统与计算流畅性的共同认知机制, 即视觉形状的快速知觉能力可以解释二者之间的相关关系。近似数量系统和计算流畅性在加工过程中依赖对形状的快速知觉, 二者在加工过程中都涉及了复杂视觉刺激的快速处理。视觉形状知觉假设得到了一系列研究结果的支持, 但局限在视觉形状知觉与二者关系的探讨上, 视觉形状知觉在二者关系中作用的加工机制仍不清楚。未来研究需要结合多种研究方法和技术, 多角度深入探讨视觉形状知觉在二者关系中作用的认知与脑机制, 并将研究结果应用于数学课堂教学和计算困难的干预中。     

非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

3～5岁幼儿基于面孔的信任判断的发展

本研究通过两个实验探讨了262名3~5岁幼儿基于面孔的信任判断能力及其年龄间差异。结果发现:(1)实验1中,当陌生面孔单张呈现时,3岁幼儿还不能正确地区分被成人评价为可信和不可信的面孔,而4、5岁幼儿已经能够基于面孔特征做出与成人基本一致的信任判断;(2)实验2中,当配对呈现可信vs.不可信两张面孔时,3~5岁幼儿都能够在日常交往情境中依据陌生交往者的面孔特征做出与成人基本一致的信任判断,并且随着年龄的增长,信任判断准确率逐步提高。这些结果表明幼儿从3岁开始已经能够基于面孔做出信任判断,随着年龄的增长,信任判断能力逐步发展。     

原发灶切除在转移性乳腺癌治疗中的地位

无论是国内还是世界其他国家,乳腺癌近年来已成为女性常患恶性肿瘤之首。早期乳腺癌通过手术、化疗、放疗及内分泌治疗等综合治疗后可以达到长期生存。然而对于晚期乳腺癌,特别是伴有远处转移的乳腺癌,疗效却不尽如人意。对于转移性乳腺癌,目前治疗优先选择毒性尽可能小的全身系统性治疗方案;而对于需要缓解症状或避免即将发生并发症（如皮肤溃疡、出血、真菌感染以及疼痛等）的情况可于全身治疗后行相应手术。然而对于转移性乳腺癌是否手术切除原发灶以及是否可从手术中获益,仍然充满争议。     

抑郁和焦虑与心血管疾病

抑郁焦虑与心血管疾病的关系最能体现身与心两者相互影响、不可分割的特点。但临床上,心血管疾病患者抑郁焦虑的诊疗率不足1％。这说明现有的诊疗理念和方式没有将心血管疾病和精神障碍联系起来,给患者全面全程的干预和管理。这样的缺陷不仅增加患者的痛苦和功能障碍,也增加心血管疾病的发病率和病死率,还增加患者及社会的医疗负担。本文结合临床经验,从心身一体的诊疗理念,谈谈抑郁焦虑与心血管疾病。     

Mothers speak differently to infants at‐risk for dyslexia

Dyslexia is a neurodevelopmental disorder manifested in deficits in reading and spelling skills that is consistently associated with difficulties in phonological processing. Dyslexia is genetically transmitted, but its manifestation in a particular individual is thought to depend on the interaction of epigenetic and environmental factors. We adopt a novel interactional perspective on early linguistic environment and dyslexia by simultaneously studying two pre‐existing factors, one maternal and one infant, that may contribute to these interactions; and two behaviours, one maternal and one infant, to index the effect of these factors. The maternal factor is whether mothers are themselves dyslexic or not (with/without dyslexia) and the infant factor is whether infants are at‐/not‐at family risk for dyslexia (due to their mother or father being dyslexic). The maternal behaviour is mothers’ infant‐directed speech (IDS), which typically involves vowel hyperarticulation, thought to benefit speech perception and language acquisition. The infant behaviour is auditory perception measured by infant sensitivity to amplitude envelope rise time, which has been found to be reduced in dyslexic children. Here, at‐risk infants showed significantly poorer acoustic sensitivity than not‐at‐risk infants and mothers only hyperarticulated vowels to infants who were not at‐risk for dyslexia. Mothers’ own dyslexia status had no effect on IDS quality. Parental speech input is thus affected by infant risk status, with likely consequences for later linguistic development.     

Daily Peer Hassles and Non-Suicidal Self-Injury in Adolescence: Gender Differences in Avoidance-Focused Emotion Regulation Processes

This study aimed to examine the mediating role of rumination, experiential avoidance, dissociation and depressive symptoms in the association between daily peer hassles and non-suicidal self-injury among adolescents. Additionally, this study explored gender differences in these associations and tested whether the proposed model was invariant across genders. The sample consisted of 776 adolescents, of them 369 are males (47.6%) and 407 are females (52.4%), aged between 12 and 18 years old from middle and high schools in Portugal. Participants completed self-report questionnaires to assess daily peer hassles, rumination in its severe component (i.e., brooding), experiential avoidance, dissociation, depressive symptoms and non-suicidal self-injury. Path analysis showed that daily peer hassles indirectly impact on non-suicidal self-injury through increased levels of brooding, experiential avoidance, dissociation, and depressive symptoms. Results indicated significant gender differences in mean scores and path analysis. Male adolescents were more likely to engage in brooding and experiential avoidance in response to external distress (particularly, daily peer hassles), whereas female adolescents were more likely to engage in non-suicidal self-injury in response to internal distress (particularly, depressive symptoms). These findings suggest relevant preventive and intervention actions to address emotion dysregulation in adolescence, by teaching them acceptance and mindfulness skills as a way of coping with stressful experiences and internal distress.     

Deradicalizing Detained Terrorists

Deradicalization of terrorists constitutes a critical component of the global “war on terror.” Unfortunately, little is known about deradicalization programs, and evidence for their effectiveness is derived solely from expert impressions and potentially flawed recidivism rates. We present the first empirical assessment of one such program: the Sri Lankan rehabilitation program for former members of the Liberation Tigers of Tamil Eelam (a terrorist organization that operated in Sri Lanka until their defeat in 2009). We offer evidence that deradicalization efforts that provided beneficiaries with sustained mechanisms for earning personal significance significantly reduced extremism after 1 year (Study 1). We also found that upon release, beneficiaries expressed lower levels of extremism than their counterparts in the community (Study 2). These findings highlight the critical role of personal significance in deradicalization efforts, offer insights into the workings of deradicalization, and suggest practical methods for improving deradicalization programs worldwide.     

Cultural identity dynamics: Capturing changes in cultural identities over time and their intraindividual organization

Important life transitions – such as migration – have the potential to enrich one's sense of self, but they are also demanding and challenging. The current research investigates how cultural identities change and become configured over time among newly arrived international students and the social factors that predict these longitudinal changes. A four‐wave longitudinal study was conducted during international students' first year in their new country (N = 278). Multivariate hierarchical linear modeling analyses allowed us to unpack both baseline (between‐person) and intraindividual change (within‐person) effects. Whereas increased psychological need satisfaction via both the new and one's heritage cultural group predicted increased identity integration, greater discrimination (i.e., both at baseline and an increase over time) predicted increased compartmentalization and the predominance (categorization) of one identity over the others. Results are discussed in light of novel theoretical developments in the acculturation and identity change literatures.     

Like Father,like Child: Early Life Family Adversity and Children’s Bullying Behaviors in Elementary School

Family adversity has been associated with children’s bullying behaviors. The evidence is, however, dominated by mothers’ perceptions of the family environment and a focus on mothers’ behaviors. This prospective population-based study examined whether children’s bullying behaviors were associated with mother- and father-reported family adversity, assessed before and after child birth. Peer-nominations were used to assess bullying behaviors of 1298 children in elementary school (mean age 7.5 years). The following paternal risk factors were prospectively associated with children’s bullying behaviors: (1) father-reported prenatal family distress, (2) fathers’ hostility at preschool age, and (3) fathers’ harsh disciplinary practices at preschool age, but effect sizes were relatively small. The effect of maternal risk factors was less consistent, only mother-reported family distress in childhood was associated with children’s bullying behaviors. The associations were independent of background family risk factors (i.e., life stress, contextual factors, and other background factors such as parental education and risk taking record) and early childhood externalizing problems. Moreover, our results indicated that father-reported family adversity predicted children’s bullying behaviors over and above the background family risk factors, early childhood externalizing problems and mother-reported family adversity. We also demonstrated that the association of fathers’ prenatal hostility and family distress with subsequent bullying behavior of their child at school was partly mediated by fathers’ harsh disciplinary practices at preschool age. Our findings highlight the importance of fathers’ behaviors in the development of children’s bullying behaviors.