Spatial learning in rats is impaired by microinfusions of protein kinase C-gamma antisense oligodeoxynucleotide within the nucleus accumbens

The nucleus accumbens (NAcc) has been shown to play a role in motor and spatial learning. Protein kinase C (PKC) has been implicated in the mechanisms of initiation and maintenance of long-term potentiation that is thought to be involved in the storage of long-term memory. In the present study, the importance of de novo synthesis of PKC-gamma within the NAcc in the acquisition and retention of spatial discrimination learning was assessed using an antisense knockdown approach. Separate groups of Long-Evans rats were exposed to acute microinfusions (6microg/microl) of PKC-gamma antisense oligodeoxynucleotide (AS-ODN), control oligodeoxynucleotide (C-ODN) or vehicle into the NAcc at 24 and 3h before each training session. Behavioral findings showed that the blockade of NAcc-PKC-gamma translation caused impairments in the early phase of learning and retention of spatial information. Biochemical experiments showed that PKC-gamma expression was reduced and Ca(2+)/phospholipid-dependent protein kinase C (PKC) activity was blocked significantly in the AS-ODN-treated rats in comparison with control rats. The present findings suggest that NAcc-PKC-gamma plays a role during the early acquisition of spatial learning. Also, retention test results suggest that NAcc-PKC-gamma may be working as an intermediate factor involved in the onset of molecular mechanisms necessary for spatial memory consolidation within the NAcc.     

Work-related stress and well-being: the roles of direct action coping and palliative coping

The purpose of the present study is to analyze the roles of direct action coping and palliative coping in the relationship between work stressors and psychological well-being, as well as their possible interactions, in a sample of 464 bank employees. Hierarchical regression analyses showed main effects of direct action coping on well-being. Palliative coping predicts higher levels of psychological distress. Contrary to what was expected, the interactions between work stressors and direct action coping were not significant. Palliative coping interacted with work stressors when predicting psychosomatic complaints. The interaction between the two types of coping was significant on psychosomatic complaints and psychological distress, but not on job satisfaction. The paper discusses theoretical and practical implications of these results, in order to design intervention strategies to prevent and manage job stress.     

Cardiovascular reactivity in hypertensives: differential effect of expressing and inhibiting emotions during moments of interpersonal stress

This study investigated cardiovascular reactivity of hypertensive adults during periods of emotional stress. Two types of instructions were given at different moments, to the same subject, either to express or to suppress feelings during role-play. Expressing, but not inhibiting, emotions elicited significantly higher reactivity during responding to negative scenes, followed by responding during the positive interactions. Blood pressure increases in both expressing and inhibiting conditions, were also found during the instruction periods. Results indicated that socially demanding situations represent a stressor whose effects may vary depending on whether or not respondents regulate expression of emotions. It is suggested that the difficulty in expressing emotions found in some hypertensive individuals may have the function of controlling or reducing blood pressure reactivity.     

Vocational choice and career planning. Spanish adaptation of Holland's Self-Directed Search (SDS-R)

The Self-Directed Search is a career-planning guide that works similarly to a vocational and professional interests inventory. A preliminary study allows detection of 68 ítems that need to be rectified, since they do not meet psychometric and semantic criteria. The current study demonstrates reliability and validity of the new adaptation. It is applied to a sample of 1460 subjects from different educational levels. As for reliability, the discrimination index of the items and internal consistency of the scales have improved. Additionally, procedures performed to verify validity (content, construct and concurrent) demonstrate that the instrument has acceptable validity. On balance, we can conclude that the instrument has sufficient scientific and technical credibility for application to the Spanish population.     

Can we fight stigma with science? The effect of aetiological framing on attitudes towards anorexia nervosa and the impact on volitional stigma

The present study experimentally investigated the way in which exposure to various aetiological explanations of anorexia nervosa (AN) differentially affected stigmatisation and behavioural intention outcomes. University students (N = 161) were randomly assigned to read one of four aetiological vignettes presenting the causes of AN as biological/genetic, socio‐cultural, environmental, or multifactorial. Results indicate that those who received a socio‐cultural explanation made stronger socio‐cultural causal attributions, fewer biological/genetic causal attributions, and were significantly less willing to sign a health insurance petition for AN. Unexpectedly, the multifactorial group considered individuals with AN as more responsible and blameworthy for their condition. Overall, findings were comparative with previous research and partially support the propositions of attribution theory. Results also suggest that by conceptualising the aetiology of AN as biological or genetic, or at least increasing one's knowledge of these contributing factors, it may be possible to decrease the level of blame‐based stigma associated with AN.     

The Importance of Context in the Genetic Transmission of U.S. Party Identification

In this study, we discuss one example where behavior genetic findings vary greatly across political contexts. We present original findings on how party identification is heritable around the 2008 election on a sample of twins from Minnesota. As this is in contrast with findings from the late 1980s and with how a mid‐2000 study interpreted their results, we explain how the increasing partisan ideological polarization could be responsible for these seemingly contradictory findings. In the Minnesota sample, we show a genetic correlation between party identification and ideology, a finding consistent in the political science literature. We highlight how heritability of political characteristics, like all others, is population specific and highly context dependent stressing its nondeterministic nature.     

Empowerment,Leadership, and Sustainability in a Faith-Based Partnership to Improve Health

Community-based participatory research is a noted approach for improving community health and reducing health disparities. Community partnerships can serve as a catalyst for change in public health efforts. This article will apply empowerment theory and sustainability principles to an existing faith-based partnership. BRANCH Out is a partnership among 13 African American churches, the City of Milwaukee Health Department—Community Nutrition, and the Medical College of Wisconsin. The partnership goal was to change inaccurate perceptions, knowledge and negative attitudes, and behaviors about chronic disease and promote healthy youth leadership. Faith-based empowerment can occur at the individual, organizational, and community level. BRANCH Out demonstrates how partnerships can be sustained in multiple ways. The partnership also highlights the unique contributions of churches to community health outcomes.