Lymphocyte subsets, cardiovascular measures and anxiety state before and after a professional examination

Controversies exist regarding the impact of psychological stress on the functioning of the immune system in humans. The aim of the present study, therefore, was to evaluate whether the condition of a pre-exam stress may or not modify resting lymphocyte subsets, as well as blood pressure and heart rate. About 22 medical residents of both sexes not suffering from any medical or psychiatric disorder were included in the study. Anxiety levels were measured by means of the Hamilton rating scale for anxiety (HRSA) and anxiety traits by means of the panic-agoraphobic spectrum self-report (PAS-SR) version and the obsessive-compulsive spectrum self-report (OBS-SR) version. The results showed that systolic blood pressure and heart rate increased significantly just before sitting an examination (t(1)) in all subjects, as compared with a calm situation (t(2)), in parallel with the increase in the HRSA total score, while no significant difference was observed in lymphocyte subsets at the two assessment times. However, men had a higher number of CD4+ cells than women at t(1) and t(2), while women showed a higher heart rate at t(1). In addition, significant correlations between CD4+ lymphocyte count and heart rate at t(1) or HRSA at t(2) were detected. These findings indicate that the acute stress determined by sitting for examination provokes changes in autonomic nervous system parameters, such as blood pressure and heart rate, as well as in the subjective feeling of anxiety, as shown by the increased HRSA total scores, which were not paralleled by modifications of lymphocyte subsets. However, individual differences, related to both sex and personality traits yet to be identified, seem to have an impact in shaping the stress response.     

Relational ties of love – A psychosocial proposal for ethics of compassionate care in health and public services

Market-based freedom of choice and user autonomy occupies a prominent position on the policy-maker agendas in many countries, increasingly more so than equity of access or equality of opportunity. The essay discusses how the introduction of market logic and consumerism in public health care services relies on, and taps into, unconscious dynamics and fantasies of invincibility while ignoring precariousness of life and our infinite potential to experience vulnerability. This creates toxicity in organisations and corrupts the moral institutional fabric. Drawing on psychosocial approaches inspired by various strands of psychoanalysis, and the theory of affective attachments to social norms offered by Judith Butler, I propose an ethics of relationality and compassionate care for the unknown ‘other’, as a way of counteracting these developments.     

Belief’s minimal rationality

Philosophical Studies - Many of our beliefs behave irrationally: this is hardly news to anyone. Although beliefs’ irrational tendencies need to be taken into account, this paper argues that...     

The Power of a Co‐witness: When More Power Leads to More Conformity

The effect of the power dynamic between co‐witnesses on memory conformity for images was investigated. Participant–confederate pairs were first presented with 50 images on a computer and then were randomly assigned to one of three social power role combinations analogous to those present in the workplace: manager and subordinate, subordinate and manager, or collaborators with equal power and status. After role assignment (but without ever engaging in the role‐related tasks), pairs were tested on whether each of 100 images (50 old and 50 new) had or had not been shown previously. Confederates always responded before participants. Subordinates were significantly less likely to conform than managers. Findings are discussed in light of the work‐related facet of social power and memory distortion. Copyright © 2013 John Wiley & Sons, Ltd.     

Delay discounting as emotional processing: An electrophysiological study

Both theoretical models and functional imaging studies implicate the involvement of emotions within the delay discounting process. However, defining this role has been difficult to establish with neuroimaging techniques given the automaticity of emotional responses. To address this, the current study examined electrophysiological correlates involved in the detection and evaluation of immediate and delayed monetary outcomes. Our results showed that modulation of both early and later ERP components previously associated with affective stimuli processing are sensitive to the signalling of delayed rewards. Together with behavioural reaction times that favoured immediacy, we demonstrated, for the first time, that time delays modify the incentive value of monetary rewards via mechanisms of emotional bias and selective visual attention. Furthermore, our data are consistent with the hypothesis that delayed and thus intangible rewards are perceived less saliently, and rely on emotion as a common currency within decision making. This study provides a new approach to delay discounting and highlights a potential novel route through which delay discounting may be investigated.     

Developmental path between language and autistic‐like impairments: a twin study

Autism spectrum disorders (ASDs) are diagnosed when individuals show impairments in three behavioural domains: communication, social interactions, and repetitive, restrictive behaviours and interests (RRBIs). Recent data suggest that these three sets of behaviours are genetically heterogeneous. Early language delay is strongly associated with ASD, but the basis for this association and the relationship with individual sub‐domains of ASD has not been systematically investigated. In the present study, data came from a population‐based twin sample with language development data at 2–4 years, measured by the MacArthur Communicative Development Inventory (MCDI), and data at 8 years using the Childhood Asperger Syndrome Test (CAST). For the total CAST and the three subscales at 8 years, approximately 300 same‐sex twin pairs were selected as showing extreme autistic‐like traits (ALTs), defined here as pairs in which at least one member of the twin pair scored in the highest 5% of the distribution. Phenotypic analyses indicated that children showing extreme social and communication ALTs (but not the RRBI subscale) at 8 years were below average in language development at 2–4 years. A regression model for selected twin data suggested that genetic influences account for this overlap, but that these effects are only in part mediated by genes that are shared between language and extreme autistic traits. Copyright © 2008 John Wiley & Sons, Ltd.     

Electrophysiological evidence for size invariance in masked picture repetition priming

This experiment examined invariance in object representations through measuring event-related potentials (ERPs) to pictures in a masked repetition priming paradigm. Pairs of pictures were presented where the prime was either the same size or half the size of the target object and the target was either presented in a normal orientation or was a normal sized mirror reflection of the prime object. Previous masked repetition priming studies have found a cascade of priming effect sensitive to perceptual (N190/P190) and semantic (N400) properties of the stimulus. This experiment found that both early (N190/P190 effects) and later effects (N400) were invariant to size, whereas only the N190/P190 effect was invariant to mirror reflection. The combination of a small prime and a mirror reflected target led to no significant priming effects. Taken together, the results of this set of experiments suggests that object recognition, more specifically, activating an object representation, occurs in a hierarchical fashion where overlapping perceptual information between the prime and target is necessary, although not always sufficient, to activate a higher level semantic representation.     

Impulsivity as a predictor of newly diagnosed depression

Depression is a severe mental disorder, whose onset has been related to environmental, genetic and personality factors. This study examined the association between impulsivity and incidence of depression. Logistic regression models were related to prospective data from two surveys (2-year time lag) conducted in a large cohort of hospital employees (N= 4,505). Only respondents with no history of depression at baseline were included. Impulsivity was predictive of the onset of depression (OR = 1.95, CI 95%= 1.28-2.97) after adjustment for age, sex and education. This association remained statistically significant after additional adjustment for a variety of baseline characteristics, such as smoking, alcohol consumption, and size of social network. A measure of mental distress (GHQ-12 responses), which may serve as a proxy measure for undiagnosed depression, was also associated with impulsivity. Impulsivity appears to be a distinct personality factor that may contribute to the onset of depressive illness in adults.