Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

An alternative to the methodology for analysis of covariance

A general statistical model for simultaneous analysis of data from several groups is described. The model is primarily designed to be used for the analysis of covariance. The model can handle any number of covariates and criterion variables, and any number of treatment groups. Treatment effects may be assessed when the treatment groups are not randomized. In addition, the model allows for measurement errors in the criterion variables as well as in the covariates. A wide variety of hypotheses concerning the parameters of the model can be tested by means of a large sample likelihood ratio test. In particular, the usual assumptions of ANCOVA may be tested.Research reported in this paper has been partly supported by the Swedish Council for Social Science Research under project Statistical methods for analysis of longitudinal data, project director Karl G. Jöreskog, and partly by the Bank of Sweden Tercentenary Foundation under project Structural Equation Models in the Social Sciences, project director Karl G. Jöreskog.     

Learning capacities during sleep: A preliminary study in a group of schizophrenic inpatients

The relationship between sleep and learning processes is analysed in a sample of schizophrenic patients, starting from more recent hypotheses about the function of REM sleep in learning and memory processes. This is done by means of two experiments: in the first AA. evaluate the possibility to elicit a simple motor conditional reflex acquired during daytime in different sleep stages. With the second experiment daytime learning performances are evaluated with and without a reinforcement administered during REM sleep. Results for the first experiment underline a qualitative difference between REM and nREM sleep in a reflexological perspective. In nREM sleep the conditional response is better maintained than in REM sleep. The second experiment confirms the possibility to improve daytime learning performances after an additional presentation of learning material in REM. The joint study of sleep abnormalities and learning and cognitive impairment in schizophrenic patients is finally suggested.     

Some theory and results for metrics for bounded response scales

In an earlier note, a new metric for bounded response scales (MBR) was introduced which resembles the city-block metric but is bounded above. It was suggested the MBR may be more appropriate than minkowski metrics for data obtained with bounded response scales. In this article, some formal properties of the MBR are investigated and it is shown that it is indeed a metric. Empirical predictions are then derived from the MBR and contrasted with those of a “monotonicity hypothesis,” which holds that dissimilarity judgements tend to be biased towards overestimation of larger distances, and with the predictions of the minkowski metrics, which imply additivity of collinear segments. Some empirical results are presented which contradict the monotonicity hypothesis and the minkowski metrics, and favor the MBR. Finally, the logic used to motivate the MBR is invoked to define a subadditive concatenation for bounded norms in the one-dimensional case, which may be useful in psychophysical work where the upper bounds are often real, rather than due to the response scale. This concatenation predicts understimation for doubling and overestimation for halving and middling tasks.     

The logic of viewpoints

In this paper a propositional logic of viewpoints is presented. The language of this logic consists of the usual modal operatorsL (of necessity) andM (of possibility) as well as of two new operatorsA andR. The intuitive interpretations ofA andR are “from all viewpoints” and “from some viewpoint”, respectively. Semantically the language is interpreted by using Kripke models augmented with sets of “viewpoints” and with a new alternativeness relation for the operatorA. Truth values of formulas are evaluated with respect to a world and a viewpoint. Various axiomatizations of the logic of viewpoints are presented and proved complete. Finally, some applications are given.     

On the logic of adverbs

In the paper I investigate aspects of adverbial modification as an operation applying an adverb or adverbial phrase to a predicate and thereby creating a new predicate. The logic of adverbial modification, on this view, belongs to the logic of predicate modifiers. The theory I present is intended to cover not only adverbial modification but also attributive modification, but problems concerning the latter will not be given any special attention.     

Nondeterministic three-valued logic: Isotonic and guarded truth-functions

Nondeterministic programs occurring in recently developed programming languages define nondeterminate partial functions. Formulas (Boolean expressions) of such nondeterministic languages are interpreted by a nonempty subset of {T (“true”), F (“false”), U (“undefined)}. As a semantic basis for the propositional part of a corresponding nondeterministic three-valued logic we study the notion of a truth-function over {T, F, U} which is computable by a nondeterministic evaluation procedure. The main result is that these truth-functions are precisely the functions satisfying four basic properties, called \( \subseteq \) -isotonic, \( \subseteq \) ^?-isotonic, hereditarily guarded, and hereditarily guard-using, and that a function satisfies these properties iff it is explicitly definable (in a certain normal form) from “if..then..else..fi”, binary choice, and constants.     

Measuring the quality of life: Why,how and what?

In this paper three questions concerning quality of life in medicine and health care are analysed and discussed: the motives for measuring the quality of life, the methods used in assessing it, and the definition of the concept. The purposes of the study are to find an ethically acceptable motive for measuring the quality of life; to identify the methodological advantages and disadvantages of the most prevalent current methods of measurement; and to present an approach towards measuring and defining the quality of life which evades the difficulties encountered and discussed. The analysis comprises measurements both in the clinical situation concerning individual patients and in research concerning whole populations. Three motives are found for evaluating the quality of human life: allocation of scarce medical resources, facilitating clinical decision making, and assisting patients towards autonomous decision making. It is argued that the third alternative is the only one which does not evoke ethical problems. As for the methods of evaluation, several prevalent alternatives are presented, ranging from scales of physical performance to more subtle psychological questionnaires. Clinical questionnaires are found to fail to provide a scientific foundation for universally measuring the quality of life. Finally, the question of definition is tackled. The classical distinction between need-based and want-based theories of human happiness is presented and discussed. The view is introduced and defended that neither of these approaches can be universally preferred to the other. The difficulty with the need approach is that it denies the subjective aspects of human life; whereas the problem of the want approach is that it tends to ignore some of the objective realities of the human existence. In conclusion, it is argued that the choice of methods as well as definitions should be left to the competent patients themselves — who are entitled, if they so wish, to surrender the judgement to the medical personnel. Technical factors as well as the requirements of respect for autonomy and informed consent support this conclusion.     

Sensorimotor synchronization: Motor responses to regular auditory patterns

Subjects (N = 32) were asked to synchronize a motor response with tones in auditory patterns. These patterns were created from six tones and six intertone intervals of equal duration. The pitch of the first tone differed from the others. It was found that subjects used three types of timing in their motor response: (1) the first intertone interval was prolonged and the second interval was shortened, (2) the second intertone interval was prolonged and the first interval was shortened, and/or (3) the first interval and the second interval were of approximately the same length. The prolongation of the fifth interval was observed during all three types of timing. The results are explained using the concept of suprasegmental control of timing, which explains a prolongation of intervals at critical control point of the patterns. The occurrence of three different strategies of timing is discussed in connection with similar principles in musical performance.