Depression and Suicidal Ideation After Predictive Testing for Huntington's Disease: A Two-Year Follow-up Study

The present study reports a two-year follow-up of psychological effects of predictive testing for Huntington's disease. Questionnaires assessing depression, general health, well-being, self injurious behavior, life satisfaction, and lifestyle were completed by 35 carriers and 58 non-carriers before the predictive test, and 2, 6, 12, and 24 months afterwards. Both carriers and non-carriers showed high suicidal ideation before the predictive testing. Depression scores and frequency of suicidal thoughts increased for carriers, compared to non-carriers, over time. There were no differences regarding life satisfaction or life style between carriers and non-carriers. Predictive testing was beneficial in reducing overall ill-health symptoms and increasing well-being for those initially expressing concern about Huntington's disease. The importance of assessing suicidal ideation and of continuing to provide adequate support is emphasized.     

A Survey of Patients’ Experiences with the Cancer Genetic Counseling Process: Recommendations for Cancer Genetics Programs

In order to promote ongoing quality improvement of not only the Penn State Cancer Genetics Program, but also other cancer risk assessment programs throughout the country, we developed, piloted and conducted a survey to explore patient expectations, experiences, and satisfaction with the cancer genetic counseling process. The comprehensive survey was mailed to 340 eligible patients, 156 (45.9%) of whom returned the completed survey within the allotted time. Responses to closed-ended questions were tallied and open-ended questions were content analyzed. Major findings show that: (1) Patients were seeking cancer-related information and support throughout the cancer risk assessment process and were interested in participating in available research studies; (2) The setting in which patients are seen for cancer risk assessment may pose potential emotional ramifications; (3) Misperceptions regarding insurance discrimination and lack of insurance coverage persist; (4) Patients view the genetic counselor as responsible for updating them about new discoveries. Specific recommendations for cancer genetics programs are included.     

An immunochemical approach to model and long-term suppression of depressive and anxiety behavior

The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.     

Getting hammered? ‥‥ students coping with alcohol

• This research draws on identity and coping theories to develop an understanding of the ways in which students with differing stances towards alcohol (both drinkers and light/non‐drinkers) deal with alcohol‐dominated social situations. We report findings from two studies, the first based on the stories of 160 students and the second based on in‐depth interviews with eight students. Our research found that many undergraduates view alcohol as playing a central role in ‘student life’, with excessive drinking being the norm. However, there is a significant group who are not comfortable with this view, nor do they ascribe to it. Choosing not to engage with the stereotypical student image presents a very real set of problems, stresses and barriers and the students discussed the various coping strategies they had in place to deal with these problems. We discuss the implications of these findings and the challenges for public policy in this area.

Copyright © 2006 John Wiley & Sons, Ltd.     

"In the storminess": multi-disciplinary approaches to scriptural images representing ethical challenges in the pastor-congregant relationship

In this qualitative study the authors examine the Scriptural images that 10 Lutheran pastors employed in describing the ethical challenges in the pastor-congregant relationship. The analysis of Scriptural images is part of a larger study on pastors' experiences of a mandatory workshop, "Crossing the Boundaries (CTB),"which is required of Evangelical Lutheran Church in Canada (ELCIC) seminarians. The pastors' images were analyzed from the four perspectives of depth psychology, theology, social ethics, and sociology. In commenting on tensions in the pastors' Scriptural images the authors note commonalities among the four theoretical perspectives and discuss implications for practice and future research.     

Recurrence plot analyses suggest a novel reference system involved in newborn spontaneous movements

The movements of newborns have been thoroughly studied in terms of reflexes, muscle synergies, leg coordination, and target-directed arm/hand movements. Since these approaches have concentrated mainly on separate accomplishments, there has remained a clear need for more integrated investigations. Here, we report an inquiry in which we explicitly concentrated on taking such a perspective and, additionally, were guided by the methodological concept of home base behavior, which Ilan Golani developed for studies of exploratory behavior in animals. Methods from nonlinear dynamics, such as symbolic dynamics and recurrence plot analyses of kinematic data received from audiovisual newborn recordings, yielded new insights into the spatial and temporal organization of limb movements. In the framework of home base behavior, our approach uncovered a novel reference system of spontaneous newborn movements.     

The ontologicalization of the Confucian concept of <Emphasis Type="Italic">Xin Xing</Emphasis>: Zhou Lianxi’s founding contribution to the Song-Ming Neo-Confucianism

The Confucian concept of “cheng” (integrity) emphasizes logical priority of value realization over “zhen shi” (reality or truth). Through value realization and the completion of being, zhenshi can be achieved. Cheng demonstrates the original unity of value and reality. Taking the concept of cheng as the core, Zhou Lianxi’s philosophy interpreted yi Dao (the Dao of change), and integrated Yi Jing (The Book of Changes) and Zhong Yong (The Doctrine of the Mean). On the one hand, it ontologicalized the Confucian concept of xin xing (mind nature), and proved and established the significance of Dao ti (the ontological Dao) as the principle and origin of the utmost goodness. On the other hand, it also extended the significance of value realization to the process of qi hua (transformation of qi) and transformation of myriad things. He proved li yi (the One Principle) of Dao ti from its many manifestations and established his own metaphysical system. Zhou Lianxi’s philosophy sets up a new theoretical direction for the Song-Ming Confucians to reconstruct Confucian Metaphysics. __________ Translated from Beijing Shifan Daxue Xuebao (Journal of Beijing Normal University)(Social Sciences Edition), Vol. 186, 2004 (6) by Yan Xin     

Eighteen month test-retest stability of the youth self report in a sample of Catalonian adolescents

The aim of this study is to assess the test-retest stability of the Spanish version of Youth Self Report after 18 mo. for a sample of 357 Catalonian high school students (158 boys and 199 girls). At Time 2 the girls' scores increased on Delinquent and Aggressive Behavior scales and, therefore on Externalizing scores. At Time 2 the boys' scores increased on Attention Problems and Delinquent Behavior and decreased on Anxious/Depressed, Social Problems, and Internalizing scales. Significant differences in the remaining scales were not observed. The test-retest intraclass correlations for the broad-band scales ranged between .62 (Internalizing) and .68 (Externalizing) and for the narrow-band scales between .37 and .67. The correlations for girls and boys were similar but slightly higher for girls on Anxious/Depressed and Thought Problems.     

Anterior medial temporal lobe activation during encoding of words: FMRI methods to optimize sensitivity

The existence of a rostrocaudal gradient of medial temporal lobe (MTL) activation during memory encoding has historically received support from positron emission tomography studies, but less so from functional MRI (FMRI) studies. More recently, FMRI studies have demonstrated that characteristics of the stimuli can affect the location of activation seen in the MTL when those stimuli are encoded. The current study tested the hypothesis that MTL activation during memory encoding is related to the modality of stimulus presentation. Subjects encoded auditorily or visually presented words in an FMRI novelty paradigm. Imaging and analysis parameters were optimized to minimize susceptibility artifact in the anterior MTL. Greater activation was observed in the anterior than posterior MTL for both modalities of stimulus presentation. The results indicate that anterior MTL activation occurred during encoding, independent of stimulus modality and provide support for the hypothesis that verbal-semantic memory processing occurs in anterior MTL. The authors suggest that technical factors are critical for observing the rostrocaudal gradient in MTL memory activation.     

Task-order coordination in dual-task performance and the lateral prefrontal cortex: an event-related fMRI study

A crucial demand in dual tasks suffering from a capacity limited processing mechanism is task-order scheduling, i.e. the control of the order in which the two component tasks are processed by this limited processing mechanism. The present study aims to test whether the lateral prefrontal cortex (LPFC) is associated with this demand. For this, 15 participants performed a psychological refractory paradigm (PRP) type dual task in an event-related functional magnetic resonance (fMRI) experiment. In detail, two choice reaction tasks, a visual (response with right hand) and an auditory (response with left hand), were presented with a temporal offset of 200 ms, while the participants were required to respond to the tasks in the order of their presentation. Importantly, the presentation order of the tasks changed randomly. Based on previous evidence, we argue that trials in which the present task order changed as compared to the previous trial (different-order trials) impose higher demands on task coordination than same-order trials do. The analyses showed that cortical areas along the posterior part of the left inferior frontal sulcus as well as the right posterior middle frontal gyrus were more strongly activated in different-order than in same-order trials, thus supporting the conclusion that one function of the LPFC for dual-task performance is the temporal coordination of two tasks. Furthermore, it is discussed that the present findings favour the active scheduling over the passive queuing hypothesis of dual-task processing.