Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus

Stress facilitates memory formation, but only when the stressor is closely linked to the learning context. These effects are, at least in part, mediated by corticosteroid hormones. Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation. This effect could not be blocked by antagonists of the mineralocorticoid receptor and glucocorticoid receptor (spironolactone and RU 38486, respectively). These data provide a biological substrate for the important behavioral observation that stress and corticosteroid hormones can facilitate learning and memory processes.     

Do humans and baboons use the same information when categorizing human and baboon faces?

What information is used for sorting pictures of complex stimuli into categories? We applied a reverse correlation method to reveal the visual features mediating categorization in humans and baboons. Two baboons and 6 humans were trained to sort, by species, pictures of human and baboon faces on which random visual noise was superimposed. On ambiguous probe trials, a human-baboon morph was presented, eliciting "human" responses on some trials and "baboon" responses on others. The difference between the noise patterns that induced the two responses made explicit the information mediating the classification. Unlike the humans, the baboons based their categorization on information that closely matched that used by a theoretical observer responding solely on the basis of the pixel similarities between the probe and training images. We show that the classification-image technique and principal components analysis provide a method to make explicit the differences in the information mediating categorization in humans and animals.     

Outline of a general model of measurement

Measurement is a process aimed at acquiring and codifying information about properties of empirical entities. In this paper we provide an interpretation of such a process comparing it with what is nowadays considered the standard measurement theory, i.e., representational theory of measurement. It is maintained here that this theory has its own merits but it is incomplete and too abstract, its main weakness being the scant attention reserved to the empirical side of measurement, i.e., to measurement systems and to the ways in which the interactions of such systems with the entities under measurement provide a structure to an empirical domain. In particular it is claimed that (1) it is on the ground of the interaction with a measurement system that a partition can be induced on the domain of entities under measurement and that relations among such entities can be established, and that (2) it is the usage of measurement systems that guarantees a degree of objectivity and intersubjectivity to measurement results. As modeled in this paper, measurement systems link the abstract theory of measuring, as developed in representational terms, and the practice of measuring, as coded in standard documents such as the International Vocabulary of Metrology.     

Sign determination of the 57 Fe electric-field gradient in Al-based crystals and icosahedral quasicrystals

Abstract

The icosahedral quasicrystals i-AIMn, isomorphically substituted by 28 at.% Fe or by a mixture of (CrFe) atoms, have been studied for the first time by in-field Mössbauer spectroscopy in order to determine the sign and asymmetry parameter of the dominant electric-field gradient (EFG) term. In addition, the orthorhombic o-Al(MnFe) and cubic α- and hexagonal β-Al(MnFe)Si crystalline phases have been studied. We show that the previous Mössbauer results are inadequate for determining whether there are two sites in the quasicrystalline structure in the ratio of the golden number. Our results for i-Al(MnFe) show that the dominant EFG is negative, with an asymmetry parameter of about 0·6. For i-Al(CrFe), essentially no deviations are found from the model of Czjzek or the Gaussian isotropic model. One crystalline phase, the hexagonal β phase, is found to have a very similar quadrupole effect to that found in i-Al(MnFe). In addition it is found that this phase undergoes a change which is at least partly of magnetic origin.     

Index for Volume 23

In this study, changes in movement coordination caused by fatigue that developed during repetitive lifting were examined. Five men performed 6 times a 5-min bout of lifting an 8-kg barbell at 15 lifts/min, using two lifting techniques; one minimized trunk rotation (squat lift), and the other minimized rotation in the knee joint (stoop lift). Kinematics and dynamics were studied by means of movement analysis and inverse dynamics, using a two-dimensional linked segment model. Within-subject variation over repetitive lifts of the time course of joint angles was smaller than between-subjects variation on the first analyzed lift. Relative timing between joint rotations did not change significantly across repetitive lifts, except between knee and hip in the squat lift. No change of the lumbosacral torque over repetitive lifts was found. The adaptability of the neural control appeared to be sufficient to accommodate the strong changes of the input-output characteristics of the muscles caused by fatigue so that an essentially constant performance of the movement act was maintained.     

Pathways to flourishing among pharmacy students: The role of study demands and lecturer support

This study investigated possible pathways to flourishing among pharmacy students attending a South African university (N = 799; females = 81.6%; Afrikaans-speakers = 84.7%, mean age = 20.42 years, SD = 2.25 years). The students completed the Mental Health Continuum – Short Form (MHC-SF) and an Overload and Lecturer Support Survey. Of the 779 pharmacy students, 40.3% self-reported as flourishing, with high mean scores on workload and lecturer support. The level of emotional well-being of year group 2 was the highest. Following structural equation modelling, overload and lecturer support explained between 18% and 31% of the variance in the flourishing of the different year groups. From the second to the third year, the predictive value of overload and lecturer support for flourishing decreased by 8.8%. Lecturer support and low overload appear to play a positive role in the flourishing of higher education students.     

Defining disease beyond conceptual analysis: an analysis of conceptual analysis in philosophy of medicine

Conceptual analysis of health and disease is portrayed as consisting in the confrontation of a set of criteria—a “definition”—with a set of cases, called instances of either “health” or “disease.” Apart from logical counter-arguments, there is no other way to refute an opponent’s definition than by providing counter-cases. As resorting to intensional stipulation (stipulation of meaning) is not forbidden, several contenders can therefore be deemed to have succeeded. This implies that conceptual analysis alone is not likely to decide between naturalism and normativism. An alternative to this approach would be to examine whether the concept of disease can be naturalized.