The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining

The basolateral complex of the amygdala (BLA) is critical for the acquisition and expression of Pavlovian fear conditioning in rats. Nonetheless, rats with neurotoxic BLA lesions can acquire conditional fear after overtraining (75 trials). The capacity of rats with BLA lesions to acquire fear memory may be mediated by the central nucleus of the amygdala (CEA). To examine this issue, we examined the influence of neurotoxic CEA lesions or reversible inactivation of the CEA on the acquisition and expression of conditional freezing after overtraining in rats. Rats with pretraining CEA lesions (whether alone or in combination with BLA lesions) did not acquire conditional freezing to either the conditioning context or an auditory conditional stimulus after extensive overtraining. Similarly, post-training lesions of the CEA or BLA prevented the expression of overtrained fear. Lastly, muscimol infusions into the CEA prevented both the acquisition and the expression of overtrained fear, demonstrating that the effects of CEA lesions are not likely due to the destruction of en passant axons. These results suggest that the CEA is essential for conditional freezing after Pavlovian fear conditioning. Moreover, overtraining may engage a compensatory fear conditioning circuit involving the CEA in animals with damage to the BLA.     

Women outperform men in distinguishing between authentic and nonauthentic smiles

Women tend to be more accurate in decoding facial expressions than men. We hypothesized that women’s better performance in decoding facial expressions extends to distinguishing between authentic and nonauthentic smiles. We showed participants portrait photos of persons who smiled because either they saw a pleasant picture (authentic smile) or were instructed to smile by the experimenter (nonauthentic smile) and asked them to identify the smiles. Participants judged single photos of persons depicting either an authentic or a nonauthentic smile, and they judged adjacent photos of the same person depicting an authentic smile and a nonauthentic smile. Women outperformed men in identifying the smiles when judging the adjacent photos. We discuss implications for judging smile authenticity in real life and limitations for the observed sex difference.     

A Matter of Life and Death: Understanding Continuing Bonds and Post-traumatic Growth When Young Adults Experience the Loss of a Close Friend

Young adults establish networks of friends for companionship, support, assistance, and resource exchange. Friends have been found to play an essential role in promoting young adults’ health and well-being. Yet, relatively little is known about how young adults cope with the death of a close friend. Studies of grief and bereavement in adulthood focus primarily on the death of a family member. In the present qualitative study, we examined the narrative accounts of 20 young adults (ages 21–34) to describe the prevalence and nature of continuing bonds and post-traumatic growth experiences in coping with the death of a close friend. Participants completed semi-structured interviews in which they described the circumstances of their friend’s death, the nature of their friendship, whether and how they continued their relationship with their deceased friend, and the impact of their friend’s death in their everyday lives. Overall, young adults articulated ways that they continued their relationship with the deceased friend that included personal communication, personal change, and homage activities. Post-traumatic growth experiences as a result of their friend’s death included behavioral changes and personal changes in outlook. The narratives of all participants reflected their simultaneous experience of continuing relationship ties with the deceased and a sense of personal growth as a result of their friend’s death. We report areas of overlap and distinctions between expressions of continuing bonds and post-traumatic growth in the lived experience of young adults coping with the loss of a friend. Implications of findings for future research are discussed.     

The Communities That Care (CTC) Family Attachment Scale: Measurement Invariance Across Family Structures

Familial protective factors are an integral part of prevention approaches aimed at problematic behaviour in adolescents. However, there is scarce evidence on the role of familial protective factors in families deviating from the two-parent family configuration. For evaluating targeted (preventive) interventions, a reliable and valid measurement of familial protective factors is crucial. We investigated the factor structure of the Communities That Care (CTC) Family Attachment Scale and tested its measurement invariance in different family structures. Adolescents (n?=?2.459, grades 6–11) from Lower Saxony, Germany filled in the German version of the CTC Youth Survey. Our analyses focused on the CTC Family Attachment Scale measuring the adolescent’s attachment to the mother and the father with six items. We evaluated the postulated unidimensional structure of the scale by confirmatory factor analysis (CFA) and tested the measurement invariance using multigroup factor analyses across different family structures (two-parent family/single-parent family). We used SPSS V.23 and the R packages lavaan and semTools. The two-factor solution for the CTC Family Attachment Scale with one factor representing attachment to the mother and one indicating attachment to the father had an adequate model fit in the total sample (χ²(5)?=?29.938; p?<?.001; CFI?=?.996; TLI?=?.988; RMSEA?=?.050, SRMR?=?.019). This two-factor solution of the CTC Family Attachment Scale showed strong measurement invariance regarding adolescents living in a two-parent family vs. those living with a single parent. The two-factor CTC Family Attachment Scale appears to be a suitable measure to assess family attachment in both two-parent and single-parent families with German adolescents.     

The bed nucleus of the stria terminalis is required for the expression of contextual but not auditory freezing in rats with basolateral amygdala lesions

Previous data suggest that overtraining can overcome fear conditioning deficits in rats with lesions of the basolateral complex of the amygdala (BLA). We have previously shown that the central nucleus of the amygdala (CEA) is essential for the acquisition and expression of conditional fear to both contextual and auditory conditioned stimuli (CSs) after overtraining. This provides strong evidence that the CEA can compensate for the loss of the BLA. Another brain area that may compensate for the loss of the BLA is the bed nucleus of the stria terminalis (BNST). We explored this possibility by examining the consequences of lesions or reversible inactivation of the BNST on the expression of overtrained fear in rats with BLA lesions. We demonstrate that lesions or inactivation of the BNST block the expression of freezing to the conditioning context, but not to an auditory conditional stimulus. These results reveal that the BNST has a critical role in the expression of contextual fear, but not fear to an auditory CS, and is therefore not the essential locus of compensation for fear learning in the absence of the BLA.     

Medial prefrontal cortex activation facilitates re-extinction of fear in rats

It has been suggested that reduced infralimbic (IL) cortical activity contributes to impairments of fear extinction. We therefore explored whether pharmacological activation of the IL would facilitate extinction under conditions it normally fails (i.e., immediate extinction). Rats received auditory fear conditioning 1 h before extinction training. Immediately prior to extinction, rats received microinfusions into the IL of the GABA(A) receptor antagonist, picrotoxin, or the NMDA receptor partial agonist, D-cycloserine. Although neither drug facilitated extinction, they both facilitated the subsequent re-extinction of fear when animals were trained in a drug-free state, suggesting that activating the IL primes behavioral extinction.     

The Suicide (SPI) and Violence Potential Indices (VPI) from the Personality Assessment Inventory: A Preliminary Exploration of Validity in an Outpatient Psychiatric Sample

Assessing risk of harm to self and others is an important component of psychological assessment, although methods for risk assessment vary considerably. The Personality Assessment Inventory (PAI) is frequently administered to evaluate general psychological functioning, as well as to provide information about suicide and violence risk. The purpose of this study was to evaluate the construct validity of the PAI Suicide (SPI) and Violence Potential (VPI) indices in a sample of 158 psychiatric outpatients referred for psychological and neuropsychological assessment within a large northeastern academic medical center between 2007 and 2011. Results generally supported the convergent and divergent validity of both SPI and VPI when evaluating groups with and without a history of suicide and violence risk, and effect sizes were moderate to large even after controlling for other covariates. SPI and VPI scores were also found to vary significantly across different psychiatric groups in ways that would be expected. Finally, we explored the relationship between SPI and VPI, and executive functioning impairment??a neuropsychological variable found to be associated with impulsive self and other-harming behaviors. Consistent with prior research, SPI and VPI were found to be significantly elevated in groups demonstrating executive dysfunction. The implications of these findings and specifically the utility of using SPI and VPI in the assessment of risk are discussed.     

The “EA brief”: A single session of parent feedback and coaching to improve emotional attachment and emotional availability (EA)

The goal of this study was to determine the extent to which a brief parenting intervention provided the context for helping families to support positive mother–child interactions as well as more optimal mother and child outcomes. Participants in this study were middle income mothers and their children were between 0–3 years of age (N = 25 dyads). Participants were filmed via Skype during a 20-minute mother–child free play and completed questionnaires (Time 1) before attending the brief intervention (involving: a single session of one-on-one parent feedback and coaching, and information via group meeting, texts, and reading) followed by a repeat of the 20-minute Skype interaction and the completion of the same questionnaires (Time 2). Paired samples t-tests were performed, revealing that mothers reported improvements in their personal well-being (using the Flourishing Scale), reports about the mother-child relationship (using the Emotional Availability Self Report), and observed interactions, particularly the child's side of the relationship (using the Emotional Availability System), from pretest to posttest. Results are discussed in terms of a single session of parent feedback and coaching (in conjunction with an informational group session and texts) potentially having a role in “planting a seed” for observed and self-reported parenting enhancement and child development.