The protection of patients’ rights in clinical trials

The Helsinki Declaration is a very important document regarding the protection of patients’ rights in clinical trials and one of the fundamental sources of operational principles for every ethics committee. Although they have been updated, the international guidelines for ethics committees continually fail to address certain issues pertaining to the protection of patients’ rights in clinical trials. These issues include, most significantly, the method of electing ethics committees (a free, secret ballot should be preferred to direct appointment), the avoidance of conflict of interest during the election of ethics committee members, and the necessary insurance coverage for the participants of clinical trials. Polish law should, on the other hand, be developed in such way as to not limit the effectiveness of ethics committees in protecting patients’ rights in clinical trials. The ideal solution would be to draft a uniform law concerning not only clinical trials, but all medical experiments. The opinions of experts who have been reviewing medical research projects for several years may prove to be especially valuable in this setting. This paper was presented at the 6th International Bioethics Conference on the subject of ‘The Responsible Conduct of Basic and Clinical Research’, held in Warsaw, Poland, 3–4 June 2005. The author is Chairman, Bioethics Committee of the Warsaw Regional Chamber of Physicians and Dentists.     

Connectivity among semantic associates: an fMRI study of semantic priming

Semantic priming refers to a reduction in the reaction time to identify or make a judgment about a stimulus that has been immediately preceded by a semantically related word or picture and is thought to result from a partial overlap in the semantic associates of the two words. A semantic priming lexical decision task using spoken words was presented in event-related fMRI and behavioral paradigms. Word pairs varied in terms of semantic relatedness and the connectivity between associates. Thirteen right-handed subjects underwent fMRI imaging and 10 additional subjects were tested in a behavioral version of the semantic priming task. It was hypothesized priming would be greatest, reaction time fastest, and cortical activation reduced the most for related word pairs of high connectivity, followed by related word pairs of low connectivity, and then by unrelated word pairs. Behavioral and fMRI results confirmed these predictions. fMRI activity located primarily in bilateral posterior superior and middle temporal regions showed modulation by connectivity and relatedness. The results suggest that these regions are involved in semantic processing.     

Traumatic stress, dissociation, and limbic irritability in patients with unipolar depression being treated with SSRIs

Recent evidence suggests that stressful experiences may be related to deficits in inhibitory functions and temporo-limbic epileptic-like activity. The latter may produce psychosensory seizure-like symptoms that may also appear in nonepileptic conditions. This study assesses whether the increased presence of the seizure-like symptoms in 113 unipolar depressive patients treated with SSRIs is associated with significantly more severe symptoms of depression, traumatic stress, and dissociation in comparison with 86 healthy controls. Results indicate that seizure-like symptoms in depressive patients have significant association with depression, symptoms of dissociation, and traumatic stress. This association suggests that processess generating seizure-like symptoms may be related to symptoms of depression, traumatic stress, and dissociation.     

A Cross-Country Evaluation of Cheating in Academia—A Comparison of Data from the US and the Czech Republic

In this study, we examine differences in cheating behaviors in higher education between two countries, namely the United States and the Czech Republic, which differ in many social, cultural and political aspects. We compare a recent (2011) Czech Republic survey of 291 students to that of 268 students in the US (Klein et al., 2007). For all items surveyed, CR students showed a higher propensity to engage in cheating. Additionally, we found more forms of serious cheating present in the Czech sample. In all cases, the differences between the US and Czech samples were statistically significant.     

The Protestant Work Ethic,Expectancy Violations,and Criminal Sentencing1

To test the hypothesis that endorsement of the Protestant work ethic would be related positively to sensitivity to criminal behavior that violated expectations, American college students (N = 159) read scenarios describing a crime committed by a typical or an atypical offender. After answering questions about the crime, they completed Mirels and Garrett's (1971) Protestant Work Ethic (PWE) scale. Extent of punishment was positively related to PWE for atypical criminal behavior. Yet, high PWEs also were more likely to perceive an affluent criminal as experiencing greater remorse for a blue‐collar crime than a white‐collar crime. We relate our results to perceptions of criminal behavior, information‐processing tendencies among individuals endorsing the PWE, and jury selection considerations.     

Reasons or rationalizations: The role of principles in the moral dumbfounding paradigm

Moral dumbfounding occurs when people maintain a moral judgment even though they cannot provide reasons for it. Recently, questions have been raised about whether dumbfounding is a real phenomenon. Two reasons have been proposed as guiding the judgments of dumbfounded participants: harm-based reasons (believing an action may cause harm) or norm-based reasons (breaking a moral norm is inherently wrong). Participants in that research (see Royzman, Kim, & Leeman, 2015), who endorsed either reason were excluded from analysis, and instances of moral dumbfounding seemingly reduced to non-significance. We argue that endorsing a reason is not sufficient evidence that a judgment is grounded in that reason. Stronger evidence should additionally account for (a) articulating a given reason and (b) consistently applying the reason in different situations. Building on this, we develop revised exclusion criteria across three studies. Study 1 included an open-ended response option immediately after the presentation of a moral scenario. Responses were coded for mention of harm-based or norm-based reasons. Participants were excluded from analysis if they both articulated and endorsed a given reason. Using these revised criteria for exclusion, we found evidence for dumbfounding, as measured by the selecting of an admission of not having reasons. Studies 2 and 3 included a further three questions relating to harm-based reasons specifically, assessing the consistency with which people apply harm-based reasons across differing contexts. As predicted, few participants consistently applied, articulated, and endorsed harm-based reasons, and evidence for dumbfounding was found.     

The Santa Clara Strength of Religious Faith Questionnaire: Confirmatory Factor Analysis

Within contemporary psychology there is increasing interest in the role of religion on behaviour and psychological functioning. Such interest can be attested to by the growth in the number of pertinent books and articles that have been published and also the development of new self-report measures of religiosity. The Santa Clara Strength of Religious Faith Questionnaire is one such recently developed measure. It is a brief self-report measure comprising 10 items that were designed to measure strength of religious faith regardless of religious denomination or affiliation. Although Plante and Boccaccini (1997a, 1997b) have provided some preliminary evidence for the reliability and validity of the scale, the factor structure of the scale has not yet been examined. The aim of the present paper was to confirm the factor structure of the scale. The hypothesised one-factor model was tested using confirmatory factor analytic methods. Data from a sample of 106 Northern Irish undergraduate university students were examined using confirmatory factor analytic methods. A one-factor model was tested and accepted on the basis of fit statistics, therefore supporting the hypothesised unidimensional structure of the scale. The present results provide further evidence that the Santa Clara Strength of Religious Faith Questionnaire is psychometrically sound and therefore it can be recommended for further use by researchers interested in the construct of strength of religious faith.