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131.
de Oliveira AR Reimer AE de Macedo CE de Carvalho MC Silva MA Brandão ML 《Neurobiology of learning and memory》2011,95(1):37-45
Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety. 相似文献
132.
Ihrke M Behrendt J Schrobsdorff H Michael Herrmann J Hasselhorn M 《Experimental psychology》2011,58(2):154-161
The existence of across-notation automatic numerical processing of two-digit (2D) numbers was explored using size comparisons tasks. Participants were Arabic speakers, who use two sets of numerical symbols—Arabic and Indian. They were presented with pairs of 2D numbers in the same or in mixed notations. Responses for a numerical comparison task were affected by decade difference and unit-decade compatibility and global distance in both conditions, extending previous findings with Arabic digits (Nuerk, Weger, & Willmes, 2001). Responses for a physical comparison task were affected by congruency with the numerical size, as indicated by the size congruency effect (SiCE). The SiCE was affected by unit-decade compatibility but not by global distance, thus suggesting that the units and decades digits of the 2D numbers, but not the whole number value were automatically translated into a common representation of magnitude. The presence of similar results for same- and mixed-notation pairs supports the idea of an abstract representation of magnitude. 相似文献
133.
Brennan AA Watson MR Kingstone A Enns JT 《Attention, perception & psychophysics》2011,73(6):1672-1693
Does person perception—the impressions we form from watching others—hold clues to the mental states of people engaged in cognitive tasks? We investigated this with a two-phase method: In Phase 1, participants searched on a computer screen (Experiment 1) or in an office (Experiment 2); in Phase 2, other participants rated the searchers’ video-recorded behavior. The results showed that blind raters are sensitive to individual differences in search proficiency and search strategy, as well as to environmental factors affecting search difficulty. Also, different behaviors were linked to search success in each setting: Eye movement frequency predicted successful search on a computer screen; head movement frequency predicted search success in an office. In both settings, an active search strategy and positive emotional expressions were linked to search success. These data indicate that person perception informs cognition beyond the scope of performance measures, offering the potential for new measurements of cognition that are both rich and unobtrusive. 相似文献
134.
135.
Gordon PC Hendrick R Johnson M Lee Y 《Journal of experimental psychology. Learning, memory, and cognition》2006,32(6):1304-1321
The nature of working memory operation during complex sentence comprehension was studied by means of eye-tracking methodology. Readers had difficulty when the syntax of a sentence required them to hold 2 similar noun phrases (NPs) in working memory before syntactically and semantically integrating either of the NPs with a verb. In sentence structures that placed these NPs at the same linear distances from one another but allowed integration with a verb for 1 of the NPs, the comprehension difficulty was not seen. These results are interpreted as indicating that similarity-based interference occurs online during the comprehension of complex sentences and that the degree of memory accessibility conventionally associated with different types of NPs does not have a strong effect on sentence processing. 相似文献
136.
The lateral and basolateral nuclei of the amygdala (LaA and BLA, respectively) serve as a filter for unconditioned and conditioned aversive information that ascends to higher structures from the brainstem, whereas the central nucleus of the amygdala (CeA) is considered to be the main output for the defense reaction. It has been shown that the dorsal periaqueductal gray (dPAG) is activated by threatening stimuli and has important functional links with the amygdala through two-way anatomical connections. In this work, we examined the influence of chemical inactivation of these nuclei of amygdala on the freezing and escape responses induced by electrical stimulation through electrodes implanted in the dPAG of Wistar rats. Each rat also bore a cannula implanted in the LaA, BLA or CeA for injections of muscimol (0.5 microg/0.5 microL) or its vehicle. The duration of freezing behavior that outlasts electrical stimulation of the dPAG was also measured. On the following day, these animals were submitted to a contextual fear-conditioning using foot shocks as unconditioned stimulus. Conditioned freezing to contextual cues previously associated with foot shocks was also inhibited by injections of muscimol into these amygdaloid nuclei. The contextual conditioned freezing behavior is generated in the neural circuits of conditioned fear in the amygdala. The data obtained also show that injections of muscimol into the three amygdaloid nuclei did not change the aversive threshold of freezing, but disrupted the dPAG post-stimulation freezing. Previous findings that the latter freezing results directly from dPAG stimulation and that it is not sensitive to a context shift suggest that it is unconditioned in nature. Thus, the amygdala can affect some, but not all, aspects of unconditioned freezing. Post-stimulation freezing may reflect the process of transferring aversive information from dPAG to higher brain structures. 相似文献
137.
This article outlines a typology of nonresponse biases that may occur in research based on voluntary participation and presents empirical evidence on the relationships between nonresponse and personality traits. We describe four different types of nonresponse occurring at the recruitment stage, during data collection, and at the stage of recruitment for further research. Personality correlates of all types of nonresponse were investigated using data from an online survey e-mailed to owners of personal Web sites, and observer ratings on the targets' personality were obtained. After reviewing the target persons' Web sites, observers judged complete nonrespondents as less agreeable and less open to experience than respondents. Furthermore, higher extraversion, higher openness to experience, and higher narcissism differentiated volunteers for follow-up research from nonvolunteers in both self- and observer ratings. We found only weak evidence of personality correlates of careless and selective item nonresponse. Findings show that nonresponse biases may have significant implications for representativeness in surveys and personality test norms. 相似文献
138.
Two studies examined the impact of witness preparation training with criminal defendants. In the first study, mock criminal defendants testified twice on videotape about minor crimes they were accused of but had not committed. Approximately half underwent witness preparation between their first and second testimony simulations. In the second study, eight public defender clients were videotaped during testimony simulations both before and after being prepared to testify. In both studies, ratings by trained evaluators indicated that witness preparation was associated with increases in the use of several testimony delivery skills, improvements in overall testimony quality, and reductions in apparent guilt. Training was also associated in both studies with an unintended decrease in expressiveness. Ratings from the mock defendant study further suggested that prepared defendants were seen as more credible than unprepared defendants because they used more effective testimony delivery skills, and as less likely to be guilty than unprepared defendants because they were perceived as being more credible. 相似文献
139.
This article reports two lexical decision experiments that provide evidence for the automatic activation of deletion neighbors—that
is, words that overlap with the presented word save for the deletion of one letter. Experiment 1 showed slower and less accurateno decisions for nonwords with deletion neighbors (e.g.,come inscome), relative to control nonwords. Experiment 2 showed slower and less accurate yes decisions for words with higher frequency
deletion neighbors, relative to control words. An important methodological implication of these results is that stimuli should
be equated using a different definition of orthographic neighborhood from that which is currently the norm. The results also
have significant theoretical implications for input coding schemes and the mechanisms underlying recognition of familiar words. 相似文献
140.
The word virus is not normally considered polymorphemic, yet it is clearly both semantically and orthographically related to the word viral. Thus, the subunit vir takes on the role of a bound morpheme. In contrast, the words future and futile also share a subunit (fut), but are semantically unrelated. The reported experiment demonstrates facilitation in a masked priming experiment for the semantically related pairs that share an initial orthographic subunit (e.g., virus-viral), but not for the semantically unrelated pairs (e.g., future-futile). Whether the subunit was pronounced the same way in the prime and target was shown to be irrelevant. Furthermore, semantic relatedness was insufficient to produce priming when orthography was not shared. It was concluded that, while the units of processing within the orthographic system may be the same for the two types of item, their representation at a higher level may depend on the correlation between form with meaning. For example, virus and viral might share a higher level representation and thus facilitate each other, whereas future and futile might be represented separately at that higher level and even compete with each other. 相似文献