Acquisition, retention, and recall of memory after injection of RS67333, a 5-HT(4) receptor agonist, into the nucleus basalis magnocellularis of the rat

The serotonin 5-HT4 subtype receptor is predominantly localized into anatomical structures linked to memory and cognition. A few experimental studies report that the acute systemic administration of selective 5-HT4 agonists has ameliorative effects on memory performance, and that these effects are reversed by contemporary administration of 5-HT4 receptor antagonists. To verify whether this procognitive action occurs via the activation of the cholinergic nucleus basalis magnocellularis (NBM)-cortical pathways, we examined the effects of RS67333, a selective partial agonist of the 5-HT4 receptor, on rat performance in a place recognition task upon local administration of the drug into the NBM area. The intra-NBM administration of RS67333 enhances the acquisition (200-500 ng/0.5 microL) and the consolidation (40-200 ng/0.5 microL) of the place recognition memory. These effects are reversed by pretreatment with the selective 5-HT4 receptor antagonist RS39604 (300 ng/0.5 microL). Conversely, the recall of memory is not affected by the 5-HT4 agonist. Our results indicate that 5-HT4 receptors located within the NBM may play a role in spatial memory and that the procognitive effect of RS67333 is due, at least in part, to the potentiation of the activity of cholinergic NBM-cortical pathways.     

Automatic spatial coding of perceived gaze direction is revealed by the Simon effect

In a typical Simon task, the (irrelevant) spatial position of the stimulus interferes with the processing of the salient characteristic (e.g., color). We used the Simon effect to investigate the automatic processing of gaze cues. We show that a simple drawing of schematic eyes automatically generates a spatially defined code of gaze direction. Although completely irrelevant to the task, direction of gaze influenced reaction times in a spatially selective two-choice discrimination based on eye color. Moreover, in one experiment employing an orthogonal manipulation of stimulus position and gaze direction, we found that coding of gaze direction is independent of stimulus spatial coding. Our finding of a “gazedirection Simon effect” is congruent with the hypothesis that gaze direction is coded by a specialized mechanism.     

The shape of holes

The shape of holes can be recognized as accurately as the shape of objects (Palmer, S. E. (1999). Vision science: photons to phenomenology. Cambridge, MA: MIT Press), yet the area enclosed by a hole is a background region, and it can be demonstrated that background regions are not represented as having shape. What is therefore the shape of a hole, if any? To resolve this apparent paradox, we suggest that the shape of a hole is available indirectly from the shape of the surrounding object. We exploited the fact that observers are faster at judging the position of convex vertices than concave ones (Perception 30 (2001) 1295), and using a figural manipulation of figure/ground we found a reversal of the relative speeds when the same contours were presented as holes instead of objects. If contours were perceived as belonging to the hole rather than the surrounding object then there would have been no qualitative difference in responses to the object and hole stimuli. We conclude that the contour bounding a hole is automatically assigned to the surrounding object, and that a change in perception of a region from object to hole always drastically changes the encoded information. We discuss the many interesting aspects of holes as a subject of study in different disciplines and predict that much insight especially about shape will continue to come from holes.     

Psychache and suicidality in adult mood disordered outpatients in Brazil

Shneidman (e.g., 1998) has theorized that psychache--general psychological and emotional pain that reaches intolerable intensity--is an important suicide-related variable, and indeed, represents a source of suicidal behavior. This conceptualization, while prominent and clinically and intuitively appealing, has received relatively little empirical scrutiny. In this study, we determined whether an index closely related to psychache, psychological quality of life, would display a special and resilient association to suicidality among 60 adult psychiatric outpatients in Brazil. All patients underwent structured clinical interviews and completed various clinical and quality-of-life measures. We found that the association between psychological quality of life and suicidality remained, even when depression, hopelessness, and other domains of quality of life were controlled. Psychache appears to deserve its place among key suicide-related variables, and deserves the attention of clinicians working with suicidal people.     

The Role of Temporal Comparison, Social Comparison, and Direct Appraisal in the Elderly's Self-Evaluations of Health

Elderly persons (n= 91) were interviewed about self- perceptions of physical health and the contribution of social comparison, temporal comparison, and direct appraisal to these judgments. Consistent with previous studies, self-assessments tended to be mainly positive (67% reported their health as “good” or “excellent”), though tempered somewhat by the individual's objective physical condition (i.e., number of chronic diseases or disabilities). Independent of objective health, respondents' ratings were more negative if they mentioned thinking about past or anticipated health. Respondents were more concerned about their health if they thought about their past or anticipated health or mentioned comparing with a specific other person. Direct feedback had no effect on health ratings. Among those who reported social comparison, ratings were more positive when worse-off others were mentioned. Temporal comparisons may be associated with more negative ratings because the elderly's past health is likely to have been better and their future (anticipated) health can be expected to become worse. If using temporal and social comparison information is associated with more negative assessments then what accounts for the generally positive self-assessments? We propose that the elderly compare themselves with a cognitively constructed stereotypical standard of the frail elderly rather than with a specific other. Because few elderly actually “fit” this stereotype, most elderly feel they are doing well.     

Social information facilitates learning about novel food sources in adult flower-visiting bats

Animal Cognition - Incorporating novel food sources into their diet is crucial for animals in changing environments. Although the utilization of novel food sources can be learned individually,...     

“Keep them out to save our inside:” discourses on immigration by the Spanish far right

Vox is a far-right, Spanish political party that has steadily grown to become the third main party in the national congress. Immigration is a major presence in Vox's political agenda. Through Critical Discourse Analysis, we analyze the party's public speeches and Twitter communications on immigration in the last 3 years, from the beginning of the COVID-19 pandemic in 2020 to the Ukraine-Russia war in 2022. These contexts have provided a fertile ground for Vox's concerns with the protection of national borders, the criminalization of African and irregular immigrants, and the Spanish Government's ineffectiveness to protect the Spaniards' homes. Vox's main discursive strategies entail constructions of migrants and migration based on dichotomous binaries, culture clash, exclusionary discourses of domopolitics, and fears of imminent social and cultural changes. These constructions are based on the unproblematized belief on essential and unchangeable values that forge the identity of the homeland, which is implicitly threatened by immigrants. Against the migratory invasion, Vox constitutes itself as the ethical protector of the Spanish society and nation, “out of care for the insiders and not out of hatred for outsiders.”     

Dimensions of health‐related dispositions in elderly people: relationships with health behaviour and personality traits

The principal aim of this study was to examine a health‐related disposition construct in elderly Italians by explorative factor analysis of the Multidimensional Health Questionnaire. The questionnaire had a two‐factor structure. The first factor was loaded by cognitive variables such as Health‐Efficacy, Health Control, Optimism, etc.; it predicted compliance with self‐rating health seeking behaviours and it was correlated with personality traits such as Emotional Stability and the Lie scale. The second factor comprised emotional dispositions including Health Anxiety, Health Depression, Health Preoccupation, etc. and it was negatively associated with Conscientiousness and Energy. Interesting results emerged for sex by age differences in both health factors. Moreover, men and women showed different correlation patterns between the health factors and the Five Factor Model. Copyright © 2000 John Wiley & Sons, Ltd.     

The dual path of the rejection (dis)identification model: A study on adolescents with a migrant background

Ethnic-based rejection, especially when prolonged over time, can result in withdrawal (e.g., resignation) and antisocial (e.g., delinquent) behaviors. Rejection (dis)identification literature suggests that identification with the minority (ethnic) group and disidentification with the majority (national) group mediate the relationship between rejection and different dimensions of well-being. Through secondary analyses of survey data from an international sample of adolescents with a migrant background (N = 1,163) we tested the predictions that, following chronic experiences of rejection, disidentification from the national (rejecting) group will increase withdrawal and feelings of resignation whereas identification with the ethic (rejected) group will have a protective role toward delinquent behaviors. Results of the path analysis were consistent with these hypotheses without significant differences between immigrant generations. The study sheds light on the multifaceted nature of identification processes following social rejection and contributes to the integration of the rejection-identification model with classical theorizations of social exclusion.