Anandamide and memory in CD1 mice: effects of immobilization stress and of prior experience

Five sets of experiments were carried out with CD1 mice tested in a one-trial inhibitory avoidance task. In a first set, immediately posttraining administrations of the endogenous ligand for the cannabinoid CB1 receptor anandamide (arachidonylethanolamide) (3 or 6 mg/kg) dose-dependently impaired memory consolidation in mice. A lower dose (1.5 mg/kg) was ineffective. In a second set of experiments, which was carried out at the same time of the first set, preexposure of the animals to the testing apparatus decreased the effect of the drug, as compared with non-preexposed mice. In a third set of experiments, administration of anandamide (3 or 6 mg/kg) prior to the retention test did not affect the retention performance of mice given posttraining injections of either saline or anandamide. These findings indicate that the memory-impairing effects of posttraining administration of anandamide are not state-dependent. In the fourth and fifth series of experiments, carried out with non-preexposed mice, an otherwise ineffective immobilization stress (15 min) enhanced the memory-impairing effect of anandamide, and an otherwise ineffective dose of naltrexone (0.1 mg/kg) completely antagonized the effect. The results are discussed in terms of attenuation of emotionality, resulting in impaired retention, following anandamide administration, and of involvement of opioid system in the effect of this drug.     

Who owns the contour of a visual hole?

Holes are useful in the study of shape, contour curvature, and border ownership. Several authors have suggested that holes have figural or quasi-figural status. I discuss three criteria to test the evidence that holes behave more like figures than like ground: (i) holes perceived as such; (ii) similar performance for holes and figures; (iii) different performance for holes and other ground regions. Using these criteria, I review the literature and conclude that holes do not have figural status in relation to border ownership. I also argue that holes are ideal stimuli to study figure-ground organisation.     

Detection of change in shape and its relation to part structure

Using a change detection paradigm (Barenholtz, E., Cohen, E. H., Feldman, J., & Singh, M. (2003). Detection of change in shape: An advantage for concavities. Cognition, 89(1) 1-9), we measured sensitivity to the changes of shapes and in particular the difference between detecting a new convex or concave vertex. We conclude that concave vertices per se are not more salient, but changes in the sequence of convexities and concavities along a contour are salient. We argue that these changes are likely to signal a change in perceived part structure.     

Mixing costs in task shifting reflect sequential processing stages in a multicomponent task

We investigated the hypothesis that mixing costs intask shifting reflect th e sequential selection of task components (e.g., stimulus categories) during task execution. This proposition was supported by Hübner, Futterer, and Steinhauser (2001), who showed that the amount of mixing costsdepends on the number of mixed task components (e.g., stimulus level and judgment). However, their results could also be explained by a task set selection account, because task components and task sets were confounded. In Experiments 1 and 2, we compared conditions in which either the number of task sets varied and the number of mixed task components was constant or vice versa. Only the number of mixed task components was predictive for the mixing costs. In Experiment 3, we replicated the additivity of mixing costs from level a ndjudgment mixing. Our results suggest thatthe mixingcosts reflect a selection strategy in which interference is reduced in a stepwise manner.     

Naive optics: acting on mirror reflections

It is known that naive observers have striking misconceptions about mirror reflections. In 5 experiments, this article systematically extends the findings to graphic stimuli, to interactive visual tasks, and finally to tasks involving real mirrors. The results show that the perceptual knowledge of nonexpert adults is far superior to their conceptual knowledge. Whereas conceptual errors include the assumption of left-right reversals in mirror images and often blatant extensions of the boundary of mirror space, the perceptual context prevents most such errors. However, a consistent bias to misjudge objects in mirrors too far to the outside is demonstrable in all cases including tasks with real mirrors. The authors present a 2-stage hypothesis consisting of an implicit bias of judging the mirror surface to be turned toward the observer's line of sight followed by a normalization that becomes explicit.     

Naive optics: understanding the geometry of mirror reflections

Paper-and-pencil tasks showed that many university students believed that when laterally approaching a mirror, they would see a reflection in the mirror before it was geometrically possible. Participants failed to adequately factor in the observer's location in the room. However, when asked about the behavior of a ray of light, participants knew about the law of reflection. No differences between psychology and physics students were detected, suggesting that the phenomenon is widespread and refractory to training. The findings were replicated with observers making judgments about image locations in a real room using a pretend mirror. Possible heuristics about mirror reflection that might explain the data are discussed. Naive optics is a promising venue to further knowledge of how observers understand basic laws of physics.     

Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: involvement of GABAergic mechanisms

In the present research the effect of the noncompetitive N-methyl-d-aspartate receptor antagonist MK-801 and ethanol combinations on memory consolidation and the involvement of GABAergic mechanisms in this effect were investigated in CD1 mice injected intraperitoneally with the drugs immediately or 120 min after training in a one-trial inhibitory avoidance apparatus and tested for retention 24 h later. The results showed that (a) the retention performances of mice were impaired in a dose-dependent manner by immediate posttraining MK-801 (0.2 and 0.3, but not 0.1 mg/kg) and ethanol (1 and 2, but not 0.5 g/kg) administrations; (b) an otherwise ineffective dose of MK-801 (0.1 mg/kg) enhanced the deleterious effect exerted by ethanol (1 and 2 g/kg); (c) an otherwise ineffective dose of muscimol (0.5 mg/kg) enhanced, while otherwise ineffective doses of picrotoxin (0.25 mg/kg) or bicuculline (0.1 mg/kg) antagonized, this effect; and (d) no effect was observed when the treatments were carried out 120 min after training, suggesting that the effects observed following immediate posttraining administrations were due to the influence on the consolidation of memory. From these experiments it is evident that (a) MK-801 enhances ethanol's effects on memory consolidation and (b) GABAergic mechanisms are involved in this effect.