Clinical Cancer Genetics Disparities among Latinos

The three major hereditary cancer syndromes in Latinos (Hereditary Breast and Ovarian Cancer, Familial Adenomatous Polyposis and Lynch Syndrome) have been shown to exhibit geographic disparities by country of origin suggesting admixture-based disparities. A solid infrastructure of clinical genetics geared towards diagnosis and prevention could aid in reducing the mortality of these cancer syndromes in Latinos. Currently, clinical cancer genetic services in Latin America are scarce. Moreover, limited studies have investigated the mutational spectrum of these cancer syndromes in Latinos resulting in gaps in personalized medicine affecting diagnosis, treatment and prevention. The following commentary discusses available genotype and clinical information on hereditary cancer in Latinos and highlights the limited access for cancer genetic services in Latin America including barriers to genetic testing and alternatives for providing better access to genetic services. In this review, we discuss the status of clinical genetic cancer services for both US Latinos and those Latinos living in Latin America.     

Awareness becomes necessary between adaptive pattern coding of open and closed curvatures

Visual pattern processing becomes increasingly complex along the ventral pathway, from the low-level coding of local orientation in the primary visual cortex to the high-level coding of face identity in temporal visual areas. Previous research using pattern aftereffects as a psychophysical tool to measure activation of adaptive feature coding has suggested that awareness is relatively unimportant for the coding of orientation, but awareness is crucial for the coding of face identity. We investigated where along the ventral visual pathway awareness becomes crucial for pattern coding. Monoptic masking, which interferes with neural spiking activity in low-level processing while preserving awareness of the adaptor, eliminated open-curvature aftereffects but preserved closed-curvature aftereffects. In contrast, dichoptic masking, which spares spiking activity in low-level processing while wiping out awareness, preserved open-curvature aftereffects but eliminated closed-curvature aftereffects. This double dissociation suggests that adaptive coding of open and closed curvatures straddles the divide between weakly and strongly awareness-dependent pattern coding.     

New trends in gender and mathematics performance: a meta-analysis

In this article, we use meta-analysis to analyze gender differences in recent studies of mathematics performance. First, we meta-analyzed data from 242 studies published between 1990 and 2007, representing the testing of 1,286,350 people. Overall, d = 0.05, indicating no gender difference, and variance ratio = 1.08, indicating nearly equal male and female variances. Second, we analyzed data from large data sets based on probability sampling of U.S. adolescents over the past 20 years: the National Longitudinal Surveys of Youth, the National Education Longitudinal Study of 1988, the Longitudinal Study of American Youth, and the National Assessment of Educational Progress. Effect sizes for the gender difference ranged between -0.15 and +0.22. Variance ratios ranged from 0.88 to 1.34. Taken together, these findings support the view that males and females perform similarly in mathematics.     

Severe pain predicts greater likelihood of subsequent suicide

Using data from the 1999 Large Health Survey of Veterans, Veterans Affairs' medical records, and the National Death Index (N = 260,254), the association between self-reported pain severity and suicide among veterans as examined, after accounting for demographic variables and psychiatric diagnoses. A Cox proportional hazards regression demonstrated that veterans with severe pain were more likely to die by suicide than patients experiencing none, mild, or moderate pain (HR: 1.33; 95% CI: 1.15, 1.54), after controlling for demographic and psychiatric characteristics. These results indicate that pain evaluations should be included in comprehensive suicide assessments and suicide prevention efforts.     

Using perceptrons to explore the reorientation task

The reorientation task is a paradigm that has been used extensively to study the types of information used by humans and animals to navigate in their environment. In this task, subjects are reinforced for going to a particular location in an arena that is typically rectangular in shape. The subject then has to find that location again after being disoriented, and possibly after changes have been made to the arena. This task is used to determine the geometric and featural cues that can be used to reorient the agent in the arena. The purpose of the present paper is to present several simulation results that show that a simple neural network, a perceptron, can be used to generate many of the traditional findings that have been obtained using the reorientation task. These results suggest that reorientation task regularities can be explained without appealing to a geometric module that is a component of spatial processing.     

Supporting adolescents who have a sibling with a life-threatening illness: An exploratory study

Aims: This research explores issues encountered by adolescents who have a sibling with a life-threatening illness, and those who work therapeutically with them. Method: Eight semi-structured, face-to-face interviews were conducted with participants who work therapeutically with this client group. Attention was given to the empathic quality of interviews. The interview sample included six females and two males, encompassing a wide demographic area within England and Wales. Five were counsellors and three had other professional trainings. Findings: Data was analysed using grounded theory. Results showed that the provision of family as well as individual therapeutic support for young people would ease stress for families and professionals alike, and that peer support was considered important. Implications for practice: The results of this research suggest that organisations working with families experiencing a life-threatening illness would benefit from attending to the quality of support offered to their staff, as well as the families they work with.     

Characteristic sounds make you look at target objects more quickly

When you are looking for an object, does hearing its characteristic sound make you find it more quickly? Our recent results supported this possibility by demonstrating that when a cat target, for example, was presented among other objects, a simultaneously presented “meow” sound (containing no spatial information) reduced the manual response time for visual localization of the target. To extend these results, we determined how rapidly an object-specific auditory signal can facilitate target detection in visual search. On each trial, participants fixated a specified target object as quickly as possible. The target’s characteristic sound speeded the saccadic search time within 215–220 msec and also guided the initial saccade toward the target, compared with presentation of a distractor’s sound or with no sound. These results suggest that object-based auditory—visual interactions rapidly increase the target object’s salience in visual search.     

A cross-cultural study of trait self-enhancement, explanatory variables, and adjustment

We investigated trait self-enhancement, explanatory variables, and adjustment in European American (n = 141), Asian American (n = 72), Mexican (n = 141), and Filipino (n = 174) college students. Consistent with trait perspectives, students in all cultural groups rated their traits with moderate to high accuracy, using peer ratings as a criterion. European Americans did not exhibit self-enhancement relative to peers, but both self and peer ratings were higher (i.e., more positive) for European Americans than for the other three groups. Support was found for some, but not all, cultural psychology explanations of self-enhancement. In all cultural groups, self-enhancement was more associated with personal (intrapsychic) adjustment than interpersonal adjustment, as judged by peers. The results provided support for an integration of trait and cultural psychology perspectives.     

Odometry and backtracking: social and individual navigation in group foraging desert harvester ants (Veromessor pergandei)

Animal Cognition - Veromessor pergandei harvester ants are group foragers which use a combination of social cues (pheromone-marked columns) and individual cues (e.g., self-generated movement,...     

Distortions in location memory

Memory for the location of a briefly presented target is often distorted in systematic ways. When people remember dot locations within a circular space, they typically show memory biases that appear to reflect a categorical strategy. However, memory for a target location can also be biased toward visible markers or landmarks. In the present study, we investigated the interaction of categorical and landmark effects by providing sectioning lines in a circular space. In the absence of lines, response biases showed categorical effects, whereas in the presence of lines, response biases suggested that participants used a landmark-based scheme. Possible relations between the strategies are discussed.