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Da Cunha C Wietzikoski S Wietzikoski EC Silva MH Chandler J Ferro MM Andreatini R Canteras NS 《Neurobiology of learning and memory》2007,87(4):451-463
The bilateral intranigral infusion of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in adult male Wistar rats caused a specific and partial loss of substantia nigra pars compacta (SNc) dopamine neurons, a partial depletion of striatal dopamine, and a deficit to learn the intra-maze cued version of the Morris water maze. Pre-training the SNc rats in the spatial version of the water maze or simply maintaining the animals on the water maze platform reversed this deficit. This improvement was even observed when the order of the extra-maze cues presented to the rats during pre-training of the spatial version was changed during training of the intra-maze cued version. However, this deficit was not reversed either by maintaining the animals on the platform if the spatial cues were surrounded and covered with a curtain or by swimming sessions in the maze without the escape platform and the curtain. These findings suggest that none of the following elements alone, learned during the spatial task pre-training, could help SNc rats learn the intra-maze cued task: improvement of swimming skills or knowledge of the existence of the escape platform; distance between the platform and the border of the pool; location of a particular extra-maze cue; relations among extra-maze cues. However, the simultaneous presence of the escape platform and extra-maze cues (irrespective of their relational configuration) during the pre-training sessions proved to be necessary for this improving effect to occur. 相似文献
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Saute JA da Silveira LE Soares FA Martini LH Souza DO Ganzella M 《Neurobiology of learning and memory》2006,85(3):206-212
Extracellular guanine-based purines, namely the nucleotides GTP, GDP, GMP and the nucleoside guanosine, exert important neuroprotective and neuromodulator roles in the central nervous system, which may be related to inhibition of the glutamatergic neurotransmission activity. In this study, we investigated GMP effects on mice inhibitory avoidance performance and the dependence on its conversion to guanosine for such effect, by using the ecto-5'-nucleotidase specific inhibitor AOPCP. We also investigated if this conversion occurs in the central nervous system or peripherally, and if guanosine and GMP affect nociception by the tail-flick test. I.p. GMP or guanosine (7.5 mg/kg) or i.c.v. GMP (480 nmol) pretraining administration was amnesic for the inhibitory avoidance task. I.c.v. AOPCP (1 nmol) administration completely reversed the amnesic effect of i.c.v. GMP, but not of i.p. GMP, indicating that peripheral conversion of GMP to guanosine is probably relevant to this effect. AOPCP alone did not interfere with the performance. Furthermore, tail-flick measurement was unaffected by i.p. GMP and guanosine, suggesting that the amnesic effect of both purines was not due to some antinociceptive effect against the footshock used in the task. All these data together, in accordance to those previously observed in studies involving glutamate uptake and seizures reinforce the idea that guanosine is the specific extracellular guanine-based purines effector and indicate that its conversion occurs not only in the central nervous system but also peripherally. 相似文献
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Marcelo Alejandro Falappa Alejandro Javier García Gabriele Kern-Isberner Guillermo Ricardo Simari 《Journal of Philosophical Logic》2013,42(1):161-193
We propose a revision operator on a stratified belief base, i.e., a belief base that stores beliefs in different strata corresponding to the value an agent assigns to these beliefs. Furthermore, the operator will be defined as to perform the revision in such a way that information is never lost upon revision but stored in a stratum or layer containing information perceived as having a lower value. In this manner, if the revision of one layer leads to the rejection of some information to maintain consistency, instead of being withdrawn it will be kept and introduced in a different layer with lower value. Throughout this development we will follow the principle of minimal change, being one of the important principles proposed in belief change theory, particularly emphasized in the AGM model. Regarding the reasoning part from the stratified belief base, the agent will obtain the inferences using an argumentative formalism. Thus, the argumentation framework will decide which information prevails when sentences of different layers are used for entailing conflicting beliefs. We will also illustrate how inferences are changed and how the status of arguments can be modified after a revision process. 相似文献