Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system

The aim of the present study was to test if the nigrostriatal pathway is an essential component for a water maze cued task learning and if it works independently of the hippocampal memory system. This hypothesis was tested using an animal model of Parkinson's disease in which male Wistar rats were lesioned in the substantia nigra pars compacta (SNc) by the intranigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), thus causing a partial depletion of striatal dopamine. SNc-lesioned and sham-operated animals were implanted bilaterally with guide cannulae above the dorsal hippocampus in order to be tested after the administration of 0.4 microl 2% lidocaine or saline into this structure. The animals were tested in a spatial or in a cued version of the water maze, memory tasks previously reported to model hippocampal-dependent spatial/relational and striatal-dependent S-R learning, respectively. Hippocampal inactivation, but not SNc lesion, impaired learning and memory in the spatial version of the water maze. An opposite situation was observed with the cued version. No significant interaction was observed between the SNc lesion and hippocampal inactivation conditions affecting scores in the spatial or in the cued version of the water maze. These results suggest that the nigrostriatal pathway is an essential part of the memory system that processes S-R learning and that it works independently of the hippocampal memory system that processes spatial/relational memories.     

Partial Structures and Jeffrey-Keynes Algebras

In Tsuji 1997 the concept of Jeffrey-Keynes algebras was introduced in order to construct a paraconsistent theory of decision under uncertainty. In the present paper we show that these algebras can be used to develop a theory of decision under uncertainty that measures the degree of belief on the quasi (or partial) truth of the propositions. As applications of this new theory of decision, we use it to analyze Popper's paradox of ideal evidence and to indicate a possible way of formalizing Keynes' theory of economic action.     

University Students’ Perceptions of Academic Cheating: Triangulating Quantitative and Qualitative Findings

Using a parallel mixed-methods design, the current study examined university students’ perceptions of academic cheating through collecting and analyzing both the quantitative and qualitative data. Our quantitative findings corroborate previous research that male students have engaged more in academic cheating than females based on students’ self-reports, and that undergraduate students are less willing to discuss issues on academic cheating as compared with their graduate counterparts. Five themes emerged from the thematic analysis of the qualitative data: (1) flexible definitions for cheating, (2) environmental promotion of cheating, (3) the moral transgression of cheating, (4) cheating as an ambiguous justification, and (5) cheating as a conscious decision making process. The mixed-methods findings indicate that there is no relationship between students’ gender or classification and their endorsements of the qualitative themes. However, non-White students are more likely to endorse the theme “cheating as an ambiguous justification.” Implications for reducing and preventing academic cheating at the university level are discussed.     

Contemporary patterns of career construction of a group of urban workers in São Paulo (Brazil)

By means of a qualitative approach, this study sought to understand the patterns of career construction in contemporary times through content analysis of the narratives generated by a set of 40 urban workers in São Paulo (Brazil), intentionally selected. Five narrative patterns of career construction were found and related to the existing concepts (organizational career, protean and boundaryless career, professional career, transitional career, and hybrid careers), which were respectively described by their core feature (nostalgia, possibility, enclosure, instrumentality, and hybrid). The main results showed that one quarter of participants sought career stability, continuity, and linearity (Nostalgia), one quarter sought flexibility and discontinuity (Possibility), about 1/7 sought a career based on the profession/occupation (Enclosure), about one-third constructed hybrid career narratives, and there was a frequent emergence of crises (Instrumentality). The main contribution of this study was confirming the hybrid nature of contemporary career constructions produced in a constant tension between stability and flexibility, as well as between permanence and change; nevertheless, based on collective standards.     

Searching for Spiritual Signatures in SETI Research

The Search for Extraterrestrial Intelligence (SETI) research assumes that we live in an intelligence-friendly universe. But do we live in a spiritual-friendly universe? We include the spiritual quest in a new multidisciplinary approach to SETI. In a thought experiment, we consider two types of alien civilizations by including a Spiritual factor in the Drake Equation. Using the analogy of planetary biomarkers and the concept of noosphere introduced by Teilhard de Chardin, we propose two spiritual markers that could evidence the presence of a noosphere in an exoplanet.     

Programs of religious/spiritual support in hospitals - five “Whies” and five “Hows”

A contemporary orientation of the hospital experience model must encompass the clients’ religious-spiritual dimension. The objective of this paper is to share a previous experience, highlighting at least five reasons hospitals should invest in this direction, and an equal number of steps required to achieve it. In the first part, the text discourses about five reasons to invest in religious-spiritual support programs: 1. Religious-spiritual wellbeing is related to better health; 2. Religious-spiritual appreciation is a standard for hospital accreditation; 3. To undo religious-spiritual misunderstandings that can affect treatment; 4. Patients demand a religious-spiritual outlook from the institution; and 5. Costs may be reduced with religious-spiritual support. In the second part, the text suggests five steps to implement religious-spiritual support programs: 1. Deep institutional involvement; 2. Formal staff training; 3. Infrastructure and resources; 4. Adjustment of institutional politics; and 5. Agreement with religious-spiritual leaders. The authors hope the information compiled here can inspire hospitals to adopt actions toward optimization of the healing experience.     

Subjective perception of health in elderly inpatients

There is evidence that subjective health is an important variable in general health outcomes. It can be an indicator of the individual's overall health status, creating a reliable and valid estimate about health. Quality of life (QoL) assessment can be associated with the individuals' subjective assessment of their own health status. The aim of the present study was to investigate variables associated with subjective perception of health in older inpatients. Ninety elderly inpatients over 60 years old were interviewed. The perception of health assessment (healthy/unhealthy) allocated elders in either of two groups. All the elders answered sociodemographic questions, the WHOQOL-100 and the Beck Depression Inventory (BDI). Comparing the group that considered themselves unhealthy to the other group, the former showed a tendency of worse QoL assessments in five out of six domains investigated. Significant differences were found for the physical and level of independence domains, as well as overall QoL. There was a significant association between health perception and lower intensity of depressive symptoms, as well as better QoL perception in the level of independence domain. This study shows the existence of an association between depressive symptoms and health assessment. It also suggests that the independence dimension is important in the elders' perception of their health status. These findings can help identify cause-effect relations between variables in aging studies involving health indicators and bring new intervention proposals for the elderly.     

Sleep deprivation effects on object discrimination task in zebrafish (<Emphasis Type="Italic">Danio rerio</Emphasis>)

The zebrafish is an ideal vertebrate model for neurobehavioral studies with translational relevance to humans. Many aspects of sleep have been studied, but we still do not understand how and why sleep deprivation alters behavioral and physiological processes. A number of hypotheses suggest its role in memory consolidation. In this respect, the aim of this study was to analyze the effects of sleep deprivation on memory in zebrafish (Danio rerio), using an object discrimination paradigm. Four treatments were tested: control, partial sleep deprivation, total sleep deprivation by light pulses, and total sleep deprivation by extended light. The control group explored the new object more than the known object, indicating clear discrimination. The partially sleep-deprived group explored the new object more than the other object in the discrimination phase, suggesting a certain degree of discriminative performance. By contrast, both total sleep deprivation groups equally explored all objects, regardless of their novelty. It seems that only one night of sleep deprivation is enough to affect discriminative response in zebrafish, indicating its negative impact on cognitive processes. We suggest that this study could be a useful screening tool for cognitive dysfunction and a better understanding of the effect of sleep-wake cycles on cognition.