Out of your hand's reach, out of my eyes' reach

When witnessing another's action, people recruit the same motor resources that enable them to efficiently perform that action, thus gazing at its target well before the agent's hand. But just to what extent does this recruitment help people in grabbing another's action target? If the latter seems to be out of the agent's reach, will this impact on people's gaze behaviour? We recorded proactive eye movements while participants witnessed someone else trying to reach for and grasp objects located either within or outside his reach. Proactivity of gaze was impaired when the targets were just out of the agent's reach. This effect is likely to be due to an interpersonal bodily space representation that allows one to map another's reaching space, thus prompting proactive eye movements towards the target just in case the agent is in the position to act upon it.     

Separating global and specific factors in developmental dyslexia

The general goal of the study was to identify global and specific components in developmental dyslexia using various manipulations based on the rapid automatization paradigm (RAN). In two experiments, we used both factor analysis and the Rate-and-Amount Model to verify if one (or more) global factor(s) and a variety of specific effects contribute to the naming (and visual search) deficits in children with dyslexia. Results of Experiment 1 indicated the presence of three global components: pictorial naming, detailed orthographic analysis, and visual search. Pictorial naming is predicated by typical RAN tasks (such as naming colors or objects), independent of set size, but also from a variety of other tasks including Stroop interference conditions. The detailed orthographic analysis factor accounts for naming of orthographic stimuli at high set size. Visual search marked tasks requiring the scanning of visual targets. Results of Experiment 2 confirmed the separation between the pictorial naming and detailed orthographic analysis factors both in the original sample and in a new group of children. Furthermore, specific effects of frequency, lexicality, and length were shown to contribute to the reading deficit. Overall, it is proposed that focusing on the profile of both global and specific effects provides a more effective and, at the same time, simpler account of the dyslexics' impairment.     

Assessing the interpersonal circumplex model in late childhood: the interpersonal behavior questionnaire for children

The authors developed the Interpersonal Behavior Questionnaire for Children with the aim of assessing the constructs of the interpersonal circumplex model, that is, Dominance and Love and their possible combinations, via third- to fifth-grade children's self- and peer reports. In the three studies presented herein, the authors examined several psychometric properties of the questionnaire. Results demonstrated that children's ratings along the questionnaire yielded the hypothesized circumplex structure of the interpersonal variables; that they reached significant association levels with external criteria; and that they were reliable. Specifically, interrater correlations were shown to reach substantive levels when inspected in older children, when scores were aggregated over raters, and when dominant behaviors were evaluated. Overall, the findings demonstrated the tenability of the circumplex model in young ages via children's ratings. The authors suggest that both personality assessment and personality development research may take advantage from using children's evaluations, in addition to adults' ratings of their children's personality.     

The feature-binding problem is an ill-posed problem

The binding problem arises when visual features (colour, orientation), said to be coded in independent brain modules, are to be integrated into unitary percepts. I argue that binding is an ill-posed problem, because those modules are now known to code jointly for multiple features, rendering the feature-binding issue moot. A hierarchical reentrant system explains the emergence of coherent visual objects from primitive features. An initial feed-forward sweep activates many high-level perceptual hypotheses, which descend to lower levels, where they correlate themselves with the ongoing activity. Low correlations are discarded, whereas the hypothesis that yields the highest correlation is confirmed and leads to conscious awareness. In this system, there is no separate binding process that actively assigns features to objects.     

干细胞生物材料来源及其伦理风险的系统性综述

对干细胞生物材料来源及其伦理风险进行系统性综述。干细胞生物材料来源主要有骨髓、脂肪、胚胎、脐带等组织。本次纳入的178篇有关不同来源的干细胞伦理风险文献中,近60%篇次是特指间充质干细胞、胚胎干细胞和造血干细胞的伦理风险,且对生物材料供者和干细胞受者以及社会伦理风险关注最多的是胚胎干细胞相关风险。此外,供者的伦理风险主要在招募、知情同意、公平性等方面。作者建议干细胞来源的生物材料供者应该得到充分的知情同意,干细胞生物材料的获取需要有严格的伦理管控,以使干细胞研究更符合伦理规范,保护供者的权益。

     

医疗诱导需求的实质：对医学公益性质的背离

医疗服务过程中诱导需求的行为屡见不鲜,过度治疗和制造病人的现象都是医疗服务过程中诱导需求的行为表现,试对诱导需求的两类典型临床案例进行对比分析,探究传统和新型的诱导需求的行为表现形式、发展过程。研究总结医疗诱导需求行为产生的原因有市场环境趋利导向、民众日益增长的医疗需求、医疗治理体系不健全等,最后提出缓解诱导行为的对策,包括打造市场规范秩序、把病人利益放在第一位、探索构建临床路径、构建高质量医学人才队伍、注重管理和医保监督、慎重修订临床指南等。

     

Acquisition of instrumental conditioned reinforcement is resistant to the devaluation of the unconditioned stimulus

The associative mechanisms responsible for the efficacy of Pavlovian stimuli during first- and second-order conditioning have been extensively studied, but little is known about the representations underlying instrumental conditioned reinforcement. The present study investigated the associative structure underlying conditioned reinforcement, by employing an unconditioned stimulus (US) devaluation procedure on a commonly used instrumental task: the acquisition of a new response with conditioned reinforcement. Whilst US-directed behaviour was abolished following devaluation, the conditioned stimulus acting as a conditioned reinforcer supported the acquisition of instrumental responding. In this preparation then, the conditioned reinforcer appears to be impervious to devaluation of its associated US, suggesting that the underlying representation maintaining behaviour is independent of the current value of the US and may reflect the activation of a central appetitive motivational state.     

Sociodemographic and Clinical Differences Between Suicide Ideators and Attempters: A Study of Mood Disordered Patients 50 Years and Older

Our study sought to characterize mood disordered suicide ideators and attempters 50 years and older admitted to a psychiatric ward either for a recent suicide attempt or for ongoing suicidal ideation. We enrolled 50 patients with suicide ideation consecutively admitted to an inpatient department and 50 patients admitted for a suicide attempt made in the last 48 hours. Suicide attempters more frequently had low social support and an age of onset of mood disorder of 46 years and older, and less frequently had a history of suicidal behaviors in the family members and pharmacological treatment, despite the fact that the groups did not differ with regard to antidepressants prescribed. The groups were not distinguishable based on several variables assumed to be risk factors for suicide behavior, such as proximal life events and stressors or alcohol use disorders. In both samples, comorbidity with organic diseases, the presence of stressful life events in the past 12 months, and a diagnosis of major depression were frequently reported. In conclusion, the presence of low social support and the absence of a pharmacotherapy may increase suicidal behaviors in patients at risk.