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221.
Antiepileptic drugs (AEDs) have diverse psychotropic profiles. Some AEDs have proven to be efficacious in the treatment of mood disorders, especially bipolar disorder. Others are ineffective as primary treatments but may be useful adjuncts for mood disorders or comorbid conditions. Valproate (acute mania and mixed episodes), carbamazepine (acute mania and mixed episodes), and lamotrigine (maintenance to delay recurrence) have United States Food and Drug Administration indications for the treatment of bipolar disorder. This article provides an overview of data on the use of AEDs in bipolar disorder, including acute mania and depression, prophylaxis, and rapid cycling. 相似文献
222.
Feldner MT Zvolensky MJ Stickle TR Bonn-Miller MO Leen-Feldner EW 《Behaviour research and therapy》2006,44(2):249-272
Anxiety-related responding to, and recovery from, a 5-min 10% carbon dioxide-enriched air presentation among 80 participants with no history of psychopathology was examined. Half of participants were instructed to suppress challenge-induced emotional responses, whereas their matched counterparts were instructed to observe such responses. Responding from immediately post-challenge through a 10-min recovery period was analyzed as a function of Anxiety Sensitivity-Physical Concerns and experimental condition using individual growth curve modeling. Anxiety Sensitivity-Physical Concerns moderated the effect of suppression only on emotion valence during recovery. In terms of main effects, suppression resulted in increased heart rate during recovery and Anxiety Sensitivity-Physical Concerns was positively associated with post-challenge self-reported anxiety. Results are discussed in terms of the potential role of inhibition-oriented affect regulation processes in the etiology of panic disorder. 相似文献
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Marcel?O.?Bonn-Miller Michael?J.?ZvolenskyEmail author Ellen?W.?Leen-Feldner Matthew?T.?Feldner Andrew?R.?Yartz 《Journal of psychopathology and behavioral assessment》2005,27(4):279-289
The present investigation evaluated the incremental validity of regular marijuana use and frequency of such use in relation to anxiety and depressive symptoms and perceived health among young adult tobacco smokers (n = 202). Approximately 72% of the sample were current marijuana smokers, using this drug on an average of 7.6 (SD = 9.2) times per week. As expected, after controlling for theoretically-relevant smoking (cigarettes per day), alcohol use, and affect factors (i.e., negative affectivity and anxiety sensitivity), marijuana use predicted anxiety symptoms and perceived general health, whereas frequency of marijuana use predicted only anxiety symptoms. These results are discussed in relation to better understanding the role of regular marijuana use in terms of anxiety-relevant emotional vulnerability and beliefs about physical health among regular smokers. 相似文献
225.
Imitation poses a unique problem: how does the imitator know what pattern of motor activation will make their action look like that of the model? Specialist theories suggest that this correspondence problem has a unique solution; there are functional and neurological mechanisms dedicated to controlling imitation. Generalist theories propose that the problem is solved by general mechanisms of associative learning and action control. Recent research in cognitive neuroscience, stimulated by the discovery of mirror neurons, supports generalist solutions. Imitation is based on the automatic activation of motor representations by movement observation. These externally triggered motor representations are then used to reproduce the observed behaviour. This imitative capacity depends on learned perceptual-motor links. Finally, mechanisms distinguishing self from other are implicated in the inhibition of imitative behaviour. 相似文献
226.
Perceived movement of a stationary visual stimulus during head motion was measured before and after adaptation intervals during which participants performed voluntary head oscillations while viewing a moving spot. During these intervals, participants viewed the spot stimulus moving alternately in the same direction as the head was moving during either .25- or 2.0-Hz oscillations, and then in the opposite direction as the head at the other of the two frequencies. Postadaptation measures indicated that the visual stimuli were perceived as stationary only if traveling in the same direction as that viewed during adaptation at the same frequency of head motion. Thus, opposite directions of spot motion were perceived as stationary following adaptation depending on head movement frequency. The results provide an example of the ability to establish dual (or “context-specific”) adaptations to altered visual—vestibular feedback. 相似文献
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Post SG 《Kennedy Institute of Ethics journal》1995,5(4):307-321
The authority of the intact self over the future severely demented self is based on notions of integrity and precedent autonomy. Despite criticism of this authority, the principle of precedent autonomy in the care of people with Alzheimer disease or other progressive and irreversible dementias retains its moral significance. 相似文献
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