Acceptance of Genetic Counseling and Testing in a Hospital-Based Series of Patients with Gynecological Cancer

Referral of patients with endometrial (EC) and/or ovarian cancer (OC) for genetic counseling is based on age at diagnosis and family history. Many patients with hereditary cancers are missed by following this strategy. We determined acceptance and mutation detection rate of offering genetic counseling and testing to unselected EC and OC patients. Therefore, in 2007, EC and OC patients were invited for genetic counseling and testing. Patients were asked for their reasons to accept or decline. Nineteen out of fifty-two EC patients (36 %) and twenty-two out of thirty-five OC patients (63 %) accepted genetic counseling, mainly to receive risk assessment for themselves and relatives. Counseling was declined mainly because patients did not want more tests or had no relatives for whom it was relevant. Eighteen out of nineteen EC patients (95 %) and twenty out of twenty-two OC patients (91 %) underwent genetic testing. One EC patient carried an MSH6 mutation (mutation detection rate: 6 %). BRCA1/2 mutations were found in two out of twenty OC patients (10 %). Eleven patients (29 %) received surveillance recommendations for themselves and their relatives. Finally, family history recorded by the gynecologist was compared to that taken by the clinical geneticist. Gynecologists reported family history in ten out of forty-one participants (24 %). In conclusion, genetic counseling and testing are acceptable to patients with OC and/or EC. The 10 % BRCA1/2 mutation detection rate and underreporting of family history by gynecologists warrant referral for genetic counseling for all OC patients, followed by BRCA1/2 testing if indicated. We recommend that microsatellite instability and immunohistochemical analysis be performed in all EC patients, followed by genetic counseling if appropriate. These strategies will lead to better cancer prevention in gynecological cancer patients and their relatives.     

Post-response stimulation and the Simon effect: Further evidence of action-effect integration

The recently proposed action-concept view of perceptual-motor behaviour posits that a stimulus which consistently follows a certain response will become associated with that response. Some evidence in favour of this view comes from the finding that the size of the Simon effect can be altered by the inclusion of post-response stimuli. However, only one study has investigated the effects of including same-side in addition to opposite-side post-response stimuli, as well as a neutral Simon condition, and, possibly because of a failure of random assignment, the results from that study were inconclusive. In light of this limitation, a Simon experiment was performed in which the location of post-response stimulation was manipulated within subjects. The results showed that: (1) the Simon effect can both decrease and increase in the presence of post-response stimuli, and (2) the amounts of Simon interference and Simon facilitation are both affected by post-response stimuli, whereas performance on neutral trials is not. These findings provide additional support for the action-concept view and suggest that further research concerning this new approach is warranted.     

A contrast effect between the concurrent production and perception of movement directions

With three experiments, we explored the nature of specific interference between the concurrent production and perception of movements. Participants were asked to move one of their hands in a certain direction while simultaneously trying to identify the direction of an independent and non-biological stimulus motion. Perceived direction of the stimulus was assessed with either above/below judgements (Experiment 1), same/different judgements (Experiment 2), or the adjustment of a line (Experiment 3). The results revealed a form of contrast effect: Perceived directions were repulsed by produced directions. Moreover, the size of the effect was comparable across the three experiments, which points to its robustness and allowed us to control for potential confounds associated with some of the perceptual measures. These results alleviate concerns regarding the interpretation of related findings and demonstrate that effects of this type are not tied to the processing of biological motion, as previously proposed.     

How do job characteristics contribute to burnout? Exploring the distinct mediating roles of perceived autonomy,competence, and relatedness

This study aimed to better understand the psychological mechanisms, referred to in the job demands–resources model as the energetic and motivational processes, that can explain relationships between job demands (role overload and ambiguity), job resources (job control and social support), and burnout (emotional exhaustion, depersonalization, and personal accomplishment). Drawing on self-determination theory, we examined whether psychological resources (perceived autonomy, competence, and relatedness) act as specific mediators between particular job demands and burnout as well as between job resources and burnout. Participants were 356 school board employees. Results of the structural equation analyses provide support for our hypothesized model, which proposes that certain job demands and resources are involved in both the energetic and motivational processes—given their relationships with psychological resources—and that they distinctively predict burnout components. Implications for burnout research and management practices are discussed.     

Working Memory Demands and Semantic Sensitivity for Prose in Mild Alzheimer's Disease

The debate continues with regard to whether degradation of semantic knowledge or deficits in information processing lead to impaired memory performance in patients with Alzheimer's disease (AD). This study examined the effects of semantic content and working memory demands on the recall and recognition abilities of patients with mild AD. Nineteen patients with probable AD and 19 demographically matched normal control participants were asked to remember prose passages that varied in semantic content (high, medium, and low level of idea importance) and working memory demands (narrative and expository passages). Compared to the controls, patients with mild AD lost the ability to recall prose in a manner consistent with the semantic structure of the passages as the demands on working memory increased. Furthermore, as the demands on working memory increased, patients recognized information in a manner that suggested their initial processing was of isolated details rather than by semantic structure. This study provides support for the hypothesis that information processing deficits contribute to impaired semantic processing in patients with mild AD.     

Improving responding to questioning using a brief retrieval training

This research examined the effect of a brief training procedure for enhancing responding to questions about witnessed events. The training was based in research on metacognition and memory, and emphasized: attending to questions, searching for multiple responses, and weighing confidence in and considering the source of responses. In the main study, adult participants viewed a video of a burglary and after a 25 min delay half received the training. All participants were then asked answerable and unanswerable questions about the video. The training resulted in fewer errors and more rejections to unanswerable questions. Analysis of response diagnosticity indicated that responses made by the trained group were more likely to be correct responses to answerable questions. A second study showed that these findings were not due to awareness of the presence of unanswerable questions. The procedure has potential as a supplement when questioning is pursued.     

Measurement variability in infant and maternal behavioral assessment

Evaluations of methodological assessments sometimes show similar, sometimes different patterns of findings reflective of different approaches to the same problem. In this study, frequencies of behaviors of infants and mothers in two cultures based on continuous coding were compared with frequencies based on time-sampling, and resulting patterns of findings were evaluated. Time-sampling and continuous coding give different estimates of absolute frequency of typical infant and maternal behaviors between individuals and between cultural groups. However, time-sampling adequately preserves the relative ranking of infant and mother behaviors among individuals and between cultural groups. If research is concerned with the relative standing of individuals and/or groups on frequency of infant or maternal behavior, then (under specified circumstances) time-sampling and continuous coding yield comparable results.